Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer

Bretin, Ludovic; Pinon, Aline; Bouramtane, Soukaina; Ouk, Catherine; Richard, Laurence; Perrin, Marie-Laure; Chaunavel, Alain; Carrion, Claire; Brégier, Frédérique; Sol, Vincent; Chaleix, Vincent; Léger, David Y.; Liagre, Bertrand

doi:10.3390/cancers11101474

Cited by 57 publications

(50 citation statements)

References 63 publications

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“…Noteworthy, and based on the evidence accumulated using the pharmacological targets reviewed here, the use of NPs to facilitate the distribution of drugs modulating lipid hydroperoxide generation in cancer patients seems to be of potential pharmacological interest. NPs can incorporate molecules on their surface that preferentially target cancer cells (i.e., folate [232] and 5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin [233]). The successful delivery of anticancer drugs can be achieved through this strategy [234][235][236][237].…”

Section: The Future Of Nanoparticles (Np) For Cancer Targeting and Timentioning

confidence: 99%

Targeting Lipid Peroxidation for Cancer Treatment

et al. 2020

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Cancer is one of the highest prevalent diseases in humans. The chances of surviving cancer and its prognosis are very dependent on the affected tissue, body location, and stage at which the disease is diagnosed. Researchers and pharmaceutical companies worldwide are pursuing many attempts to look for compounds to treat this malignancy. Most of the current strategies to fight cancer implicate the use of compounds acting on DNA damage checkpoints, non-receptor tyrosine kinases activities, regulators of the hedgehog signaling pathways, and metabolic adaptations placed in cancer. In the last decade, the finding of a lipid peroxidation increase linked to 15-lipoxygenases isoform 1 (15-LOX-1) activity stimulation has been found in specific successful treatments against cancer. This discovery contrasts with the production of other lipid oxidation signatures generated by stimulation of other lipoxygenases such as 5-LOX and 12-LOX, and cyclooxygenase (COX-2) activities, which have been suggested as cancer biomarkers and which inhibitors present anti-tumoral and antiproliferative activities. These findings support the previously proposed role of lipid hydroperoxides and their metabolites as cancer cell mediators. Depletion or promotion of lipid peroxidation is generally related to a specific production source associated with a cancer stage or tissue in which cancer originates. This review highlights the potential therapeutical use of chemical derivatives to stimulate or block specific cellular routes to generate lipid hydroperoxides to treat this disease.

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Section: The Future Of Nanoparticles (Np) For Cancer Targeting and Timentioning

confidence: 99%

Targeting Lipid Peroxidation for Cancer Treatment

et al. 2020

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“…Many other types of cancer have been the focus of PDT either as primary or complementary treatment, and the trend is similar in the majority of the new approaches. Gastric, colorectal, urogenital, bladder, and pancreatic cancer, besides previously discussed breast and lung cancers, are among the ones where PDT therapies have been deeply researched, either looking to improve the delivery of the known photosensitizers or oxygen, or improve the capability of the light source [ 155 , 156 , 157 , 158 , 159 , 160 , 161 ]. Nevertheless, the search for new photosensitizers is also an active target for the development of PDT.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Oliveira

Correia

Pereira

et al. 2020

IJMS

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Due to their physical and chemical characteristics, anthocyanins are amongst the most versatile groups of natural compounds. Such unique signature makes these compounds a focus in several different areas of research. Anthocyanins have well been reported as bioactive compounds in a myriad of health disorders such as cardiovascular diseases, cancer, and obesity, among others, due to their anti-inflammatory, antioxidant, anti-diabetic, anti-bacterial, and anti-proliferative capacities. Such a vast number of action mechanisms may be also due to the number of structurally different anthocyanins plus their related derivatives. In this review, we highlight the recent advances on the potential use of anthocyanins in biological systems with particular focus on their photoprotective properties. Topics such as skin aging and eye degenerative diseases, highly influenced by light, and the action of anthocyanins against such damages will be discussed. Photodynamic Therapy and the potential role of anthocyanins as novel photosensitizers will be also a central theme of this review.

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“…Silica NPs (80 nm) coated with xylan–TPPOH conjugate was studied for such purpose and showed significant phototoxic effects from post-PDT ROS generation, and stronger cellular uptake in the human colorectal cancer cell line. They showed high anticancer efficacy [ 136 ]. The dual specificity of PDT relies on the accumulation of PS in tumour tissue and localized light delivery.…”

Section: Cancer Therapymentioning

confidence: 99%

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

2020

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Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars, are very commonly used in biomedical imaging and cancer therapy. They make excellent drug carriers, imaging contrast agents, photothermal agents, photoacoustic agents, and radiation dose enhancers, among other applications. Recent advances in nanotechnology have led to the use of nanomaterials in many areas of functional imaging, cancer therapy, and synergistic combinational platforms. This review will systematically explore various applications of nanomaterials in biomedical imaging and cancer therapy. The medical imaging modalities include magnetic resonance imaging, computed tomography, positron emission tomography, single photon emission computerized tomography, optical imaging, ultrasound, and photoacoustic imaging. Various cancer therapeutic methods will also be included, including photothermal therapy, photodynamic therapy, chemotherapy, and immunotherapy. This review also covers theranostics, which use the same agent in diagnosis and therapy. This includes recent advances in multimodality imaging, image-guided therapy, and combination therapy. We found that the continuous advances of synthesis and design of novel nanomaterials will enhance the future development of medical imaging and cancer therapy. However, more resources should be available to examine side effects and cell toxicity when using nanomaterials in humans.

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Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer

Cited by 57 publications

References 63 publications

Targeting Lipid Peroxidation for Cancer Treatment

Targeting Lipid Peroxidation for Cancer Treatment

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

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