Photodynamic Therapy and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with AuNPs

Zhang, Wei; Lu, Yanli; Zang, Yang; Han, Jinhui; Xiong, Qingyun; Xiong, Jinping

doi:10.3390/ijms23031227

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…According to Zhang et al, the upconversion of Au-doped nanoparticles has a relatively high light intensity. In particular, Au-doped UCNPs are non-toxic to tissues, making them extremely effective ( Zhang et al, 2022 ). In turn, the Tumor Microenvironment (TME)-Responsive nanoparticles group includes such platforms as: nanogels, hybrid micelles, nanocoatings, and miceplexes.…”

Section: Resultsmentioning

confidence: 99%

Photodynamic therapy and associated targeting methods for treatment of brain cancer

Bartusik-Aebisher,

Serafin,

Dynarowicz

et al. 2023

Front. Pharmacol.

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Brain tumors, including glioblastoma multiforme, are currently a cause of suffering and death of tens of thousands of people worldwide. Despite advances in clinical treatment, the average patient survival time from the moment of diagnosis of glioblastoma multiforme and application of standard treatment methods such as surgical resection, radio- and chemotherapy, is less than 4 years. The continuing development of new therapeutic methods for targeting and treating brain tumors may extend life and provide greater comfort to patients. One such developing therapeutic method is photodynamic therapy. Photodynamic therapy is a progressive method of therapy used in dermatology, dentistry, ophthalmology, and has found use as an antimicrobial agent. It has also found wide application in photodiagnosis. Photodynamic therapy requires the presence of three necessary components: a clinically approved photosensitizer, oxygen and light. This paper is a review of selected literature from Pubmed and Scopus scientific databases in the field of photodynamic therapy in brain tumors with an emphasis on glioblastoma treatment.

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Section: Resultsmentioning

confidence: 99%

Photodynamic therapy and associated targeting methods for treatment of brain cancer

Bartusik-Aebisher,

Serafin,

Dynarowicz

et al. 2023

Front. Pharmacol.

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“…Their high mobility facilitates easy transport to various organs and effective penetration into targeted regions. Conjugates with therapeutic molecules enable selective drug delivery to diseased tissues, such as cancer cells, and their size is comparable to DNA but significantly smaller than red blood cells [6]. This enhances performance and imparts distinctive physical, chemical, and optical properties, valuable in the medical field for cancer treatment and detection.…”

Section: Introductionmentioning

confidence: 99%

Revolutionizing Cancer Care: Advances in Carbon-Based Materials for Diagnosis and Treatment

Khan,

Tahir,

Asim

et al. 2024

Cureus

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Cancer involves intricate pathological mechanisms marked by complexities such as cytotoxicity, drug resistance, stem cell proliferation, and inadequate specificity in current chemotherapy approaches. Cancer therapy has embraced diverse nanomaterials renowned for their unique magnetic, electrical, and optical properties to address these challenges. Despite the expanding corpus of knowledge in this area, there has been less advancement in approving nano drugs for use in clinical settings. Nanotechnology, and more especially the development of intelligent nanomaterials, has had a profound impact on cancer research and treatment in recent years. Due to their large surface area, nanoparticles can adeptly encapsulate diverse compounds.Furthermore, the modification of nanoparticles is achievable through a broad spectrum of bio-based substrates, including DNA, aptamers, RNA, and antibodies. This functionalization substantially enhances their theranostic capabilities. Nanomaterials originating from biological sources outperform their conventionally created counterparts, offering advantages such as reduced toxicity, lower manufacturing costs, and enhanced efficiency. This review uses carbon nanomaterials, including graphene-based materials, carbon nanotubes (CNTs) based nanomaterials, and carbon quantum dots (CQDs), to give a complete overview of various methods used in cancer theranostics. We also discussed their advantages and limitations in cancer diagnosis and treatment settings. Carbon nanomaterials might significantly improve cancer theranostics and pave the way for fresh tumor diagnosis and treatment approaches. More study is needed to determine whether using nano-carriers for targeted medicine delivery may increase material utilization. More insight is required to explore the correlation between heightened cytotoxicity and retention resulting from increased permeability.

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“…Moreover, nanoparticles can function as targeting agents to target specific molecules in cancer cells for better cancer imaging, which can improve cancer diagnosis. Several studies have demonstrated the potential of nanoparticles in enhancing cancer imaging for improved detection [ 2 , 3 ]. Nanomaterials are produced for precise applications in cancer diagnosis and detection and the main objective is to synthesize nanomaterials that are effective and can be easily delivered to cancerous tumor cells [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology in Cancer Diagnosis and Treatment

et al. 2023

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Traditional cancer diagnosis has been aided by the application of nanoparticles (NPs), which have made the process easier and faster. NPs possess exceptional properties such as a larger surface area, higher volume proportion, and better targeting capabilities. Additionally, their low toxic effect on healthy cells enhances their bioavailability and t-half by allowing them to functionally penetrate the fenestration of epithelium and tissues. These particles have attracted attention in multidisciplinary areas, making them the most promising materials in many biomedical applications, especially in the treatment and diagnosis of various diseases. Today, many drugs are presented or coated with nanoparticles for the direct targeting of tumors or diseased organs without harming normal tissues/cells. Many types of nanoparticles, such as metallic, magnetic, polymeric, metal oxide, quantum dots, graphene, fullerene, liposomes, carbon nanotubes, and dendrimers, have potential applications in cancer treatment and diagnosis. In many studies, nanoparticles have been reported to show intrinsic anticancer activity due to their antioxidant action and cause an inhibitory effect on the growth of tumors. Moreover, nanoparticles can facilitate the controlled release of drugs and increase drug release efficiency with fewer side effects. Nanomaterials such as microbubbles are used as molecular imaging agents for ultrasound imaging. This review discusses the various types of nanoparticles that are commonly used in cancer diagnosis and treatment.

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Photodynamic Therapy and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with AuNPs

Cited by 6 publications

References 24 publications

Photodynamic therapy and associated targeting methods for treatment of brain cancer

Photodynamic therapy and associated targeting methods for treatment of brain cancer

Revolutionizing Cancer Care: Advances in Carbon-Based Materials for Diagnosis and Treatment

Nanotechnology in Cancer Diagnosis and Treatment

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