Photodynamic therapy and two-photon bio-imaging applications of hydrophobic chromophores through amphiphilic polymer delivery

Gallavardin, Thibault; Maurin, Mathieu; Marotte, Sophie; Simon, Turibius; Gabudean, Ana-Maria; Bretonnière, Yann; Lindgren, Mikael; Lerouge, Frédéric; Baldeck, Patrick L.; Stéphan, Olivier; Leverrier, Yann; Marvel, Jacqueline; Parola, Stéphane; Maury, Olivier; Andraud, Chantal

doi:10.1039/c0pp00381f

Cited by 77 publications

(43 citation statements)

References 60 publications

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“…Four years later another group demonstrated that singlet oxygen was efficiently generated by excitation of 4-(diphenylaminostilbene)-substituted porphyrin-based PSs molecularly designed for enhanced two-photon absorption at 780 nm (within the "tissue window") using a 150 femtosecond pulsed laser [50]. The development of other 2P-PDT agents such as lipophilic quadrupolar chromophores carrying anthracenyl and dibromobenzene residues [103] and hydrophilic conjugated porphyrin dimers [104,105] with realistic and practical 2PA cross-sections having at least >100 GM (e.g. 8,000 -17,000 GM for the porphyrin dimers), good photostability and high light absorptivity within the "tissue window" have also been reported.…”

Section: Two-photon Pdt (2p-pdt)mentioning

confidence: 99%

“…The quadrupolar chromophores demonstrated effective cell killing upon 2PE at 820 nm and the conjugated porphyrin dimers were shown to be suitable for 2P-PDT in in vivo AMD models [103][104][105]. Dahlstedt et al (2009) investigated the effects of 2P-PDT using a range of conjugated porphyrin dimers with high two-photon absorption cross sections up to 17,000 GM.…”

Section: Two-photon Pdt (2p-pdt)mentioning

confidence: 99%

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New Approaches to Photodynamic Therapy from Types I, II and III to Type IV Using One or More Photons

Scherer

Bisby²,

Botchway³

et al. 2017

ACAMC

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Photodynamic therapy (PDT) is an alternative cancer treatment to conventional surgery, radiotherapy and chemotherapy. It is based on activating a drug with light that triggers the generation of cytotoxic species that promote tumour cell killing. At present, PDT is mainly used in the treatment of wet age-related macular degeneration, for precancerous conditions of the skin (e.g. actinic keratosis) and in the palliative care of advanced cancers, for instance of the bladder or the oesophagus. Due to a lack of phase III clinical trials and limitations of light penetration to deeper lying tumours (in excess of 1 cm), PDT is still not used as a first line cancer treatment, which is surprising given the first clinical trials by Dougherty's group dating back to the 1970's. However research continues to demonstrate the potential benefits of PDT and the need to stimulate funding and uptake of clinical studies using next generation photosensitizers offering advanced targeted delivery, improved photodynamic dose combined with modern light delivery technologies. This review surveys the available PDT treatments and emerging novel developments in the field with a particular focus on two-photon techniques that are anticipated to improve the effectiveness of PDT in tissues at depth and on next generation drugs that work without the need of the presence of oxygen for photosensitization making them effective where hypoxia has taken hold.

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Section: Two-photon Pdt (2p-pdt)mentioning

confidence: 99%

Section: Two-photon Pdt (2p-pdt)mentioning

confidence: 99%

New Approaches to Photodynamic Therapy from Types I, II and III to Type IV Using One or More Photons

Scherer

Bisby²,

Botchway³

et al. 2017

ACAMC

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show abstract

“…Pluronics (poloxamers) are commercially available watersoluble triblock copolymers of poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO-PEO) and have been frequently used as a solubilization agent in drug formulations. Gallavardin et al [105] used the pluronic nanoparticles for encapsulating two-photon chromophores. Chowdhary et al [106] compared the pluronic P123 formulation with a lipidbased system to improve the verteporfi n delivery to lipoproteins in tumor and arthritis mouse models.…”

Section: Polymeric Micellesmentioning

confidence: 99%

Can nanotechnology potentiate photodynamic therapy?

Huang¹,

Sharma

Dai³

et al. 2012

Nanotechnology Reviews

126

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Photodynamic therapy (PDT) uses the combination of nontoxic dyes and harmless visible light to produce reactive oxygen species that can kill cancer cells and infectious microorganisms. Due to the tendency of most photosensitizers (PS) to be poorly soluble and to form nonphotoactive aggregates, drug-delivery vehicles have become of high importance. The nanotechnology revolution has provided many examples of nanoscale drug-delivery platforms that have been applied to PDT. These include liposomes, lipoplexes, nanoemulsions, micelles, polymer nanoparticles (degradable and nondegradable), and silica nanoparticles. In some cases (fullerenes and quantum dots), the actual nanoparticle itself is the PS. Targeting ligands such as antibodies and peptides can be used to increase specifi city. Gold and silver nanoparticles can provide plasmonic enhancement of PDT. Two-photon excitation or optical upconversion can be used instead of one-photon excitation to increase tissue penetration at longer wavelengths. Finally, after sections on in vivo studies and nanotoxicology, we attempt to answer the title question, " can nanotechnology potentiate PDT ? "

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“…One major issue when using fluorescent dyes is their loss of fluorescence intensity within a certain period of irradiation [98,99] (e.g. bleaching effect).…”

Section: Fluorescent Studiesmentioning

confidence: 99%

From gold nanoparticles to luminescent nano-objects: experimental aspects for better gold-chromophore interactions

Navarro¹,

Lerouge

2016

Nanophotonics

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Abstract:Gold nanoparticles have been the center of interest for scientists since many decades. Within the last 20 years, the research in that field has soared with the possibility to design and study nanoparticles with controlled shapes. From spheres to more complex shapes such as stars, or anisotropic architectures like rods or bipyramids, these new systems feature plasmonic properties making them the tools of choice for studies on light-matter interactions. In that context, fluorescence quenching and enhancement by gold nanostructures is a growing field of research. In this review, we report a nonexhaustive summary of the synthetic modes for various shapes and sizes of isotropic and anisotropic nanoparticles. We then focus on fluorescent studies of these gold nano-objects, either considering "bare" particles (without modifications) or hybrid particles (surface interaction with a chromophore). In the latter case, the well-known metal-enhanced fluorescence (MEF) is more particularly developed; the mechanisms of MEF are discussed in terms of the additional radiative and non-radiative decay rates caused by several parameters such as the vicinity of the chromophore to the metal or the size and shape of the nanostructures.

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Photodynamic therapy and two-photon bio-imaging applications of hydrophobic chromophores through amphiphilic polymer delivery

Cited by 77 publications

References 60 publications

New Approaches to Photodynamic Therapy from Types I, II and III to Type IV Using One or More Photons

New Approaches to Photodynamic Therapy from Types I, II and III to Type IV Using One or More Photons

Can nanotechnology potentiate photodynamic therapy?

From gold nanoparticles to luminescent nano-objects: experimental aspects for better gold-chromophore interactions

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