Photodynamic Therapy as a New Treatment for Chronic Rhinosinusitis - A Systematic Review

Abstract

This review examines the latest evidence for photodynamic therapy (PDT) in treating chronic rhinosinusitis. MedLine, EMBASE and TRIP Database searches were conducted using the terms: "photodynamic" or "phototherapy" or "photo" and "sinusitis" or "rhinosinusitis," date range January 2000 to May 2020. A total of 192 records were initially identified, after duplicates and exclusions, 9 full papers and 3 abstracts were included. All study types including in-vitro, animal and human studies were evaluated. Whilst there is in-vitro evidence for the efficacy of PDT's bactericidal effect on drug resistant bacteria and biofilm viability, there are few clinical studies. PDT is a promising area of research, but larger, focused studies looking at the safety, delivery, efficacy, and patient selection are required before it can be considered a viable treatment for CRS.

Synthesis of a new chlorin photosensitizer for photodynamic therapy against colon cancer

“…More importantly, photodynamic therapy is a long-term treatment program with extremely low systemic toxicity caused by longterm medication. 2 As a new treatment technology combining medicine and medical equipment, PDT is now primarily approved for lumen diseases including nasosinusitis and verruca acuminate, 4,5 as well as for multiple cancers, such as nasopharyngeal cancer, bladder cancer, lung cancer, esophageal cancer, cervical cancer and head and neck cancer. [6][7][8][9] In the existing studies on photosensitizers, chlorins are the most widely studied due to their stability from the large ring structure.…”