Photodynamic therapy as salvage therapy for patients with nasopharyngeal carcinoma experiencing local failures following definitive radiotherapy

Stoker, Sharon D.; Indrasari, Sagung Rai; Herdini, Camelia; Hariwiyanto, Bambang; Karakullukçu, Barış; Dhamiyati, Wigati; Widayati, Kartika; Romdhoni, Achmad Chusnu; Fles, Renske; Haryana, Sofia Mubarika; Wildeman, Maarten A.; Tan, I. Bing

doi:10.1016/j.pdpdt.2015.04.005

Cited by 23 publications

(17 citation statements)

References 22 publications

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“…With the development of different illumination strategies like the nasopharynx applicator but also interstitial illuminations these lesions were accessible to PDT treatments. Treatment of nasopharyngeal carcinoma with mTHPC-PDT can result in CR and lead to prolonged survival for patients [ 208 ]. A prospective study using ultrasound guided interstitial PDT for deep seated pathologies showed good results with most patients reporting improved QoL and improvement of limb function [ 209 ].…”

Section: Pdt In Clinical Trialsmentioning

confidence: 99%

Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions

Straten

Mashayekhi

Bruijn

et al. 2017

Cancers

845

675

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Photodynamic therapy (PDT) is a clinically approved cancer therapy, based on a photochemical reaction between a light activatable molecule or photosensitizer, light, and molecular oxygen. When these three harmless components are present together, reactive oxygen species are formed. These can directly damage cells and/or vasculature, and induce inflammatory and immune responses. PDT is a two-stage procedure, which starts with photosensitizer administration followed by a locally directed light exposure, with the aim of confined tumor destruction. Since its regulatory approval, over 30 years ago, PDT has been the subject of numerous studies and has proven to be an effective form of cancer therapy. This review provides an overview of the clinical trials conducted over the last 10 years, illustrating how PDT is applied in the clinic today. Furthermore, examples from ongoing clinical trials and the most recent preclinical studies are presented, to show the directions, in which PDT is headed, in the near and distant future. Despite the clinical success reported, PDT is still currently underutilized in the clinic. We also discuss the factors that hamper the exploration of this effective therapy and what should be changed to render it a more effective and more widely available option for patients.

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Section: Pdt In Clinical Trialsmentioning

confidence: 99%

Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions

Straten

Mashayekhi

Bruijn

et al. 2017

Cancers

845

675

View full text Add to dashboard Cite

show abstract

“…At the end of the therapy, a remarkable long-term response was described with no tumour progression and no lymph node metastasis. The same team conducted a similar study on 21 patients which showed that Foscan ® PDT is effective in treating local failures of NPC with a depth of less than 10 mm [ 111 ]. Nyst et al reported 22 patients treatment with Foscan ® PDT and once again this treatment was well tolerated by patients and showed efficacy against residual or recurrent NPC [ 112 ].…”

Section: Npc Novel Therapiesmentioning

confidence: 99%

Novel Therapies Boosting T Cell Immunity in Epstein Barr Virus-Associated Nasopharyngeal Carcinoma

Renaud

Lefebvre

Mordon

et al. 2020

IJMS

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Nasopharyngeal carcinoma (NPC) is a malignant tumour of the head and neck affecting localised regions of the world, with the highest rates described in Southeast Asia, Northern Africa, and Greenland. Its high morbidity rate is linked to both late-stage diagnosis and unresponsiveness to conventional anti-cancer treatments. Multiple aetiological factors have been described including environmental factors, genetics, and viral factors (Epstein Barr Virus, EBV), making NPC treatment that much more complex. The most common forms of NPCs are those that originate from the epithelial tissue lining the nasopharynx and are often linked to EBV infection. Indeed, they represent 75–95% of NPCs in the low-risk populations and almost 100% of NPCs in high-risk populations. Although conventional surgery has been improved with nasopharyngectomy’s being carried out using more sophisticated surgical equipment for better tumour resection, recent findings in the tumour microenvironment have led to novel treatment options including immunotherapies and photodynamic therapy, able to target the tumour and improve the immune system. This review provides an update on the disease’s aetiology and the future of NPC treatments with a focus on therapies activating T cell immunity.

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“…PDT has attracted considerable attention because it is minimally invasive and has low mutagenic potential and low systemic toxicity . In clinical settings, PDT agents (photosensitizers [PSs]) are administered intravenously and target some proteins such as eEF1A1, followed by light irradiation at the tumor sites . PDT has three main components: a PS, oxygen, and light .…”

mentioning

confidence: 99%

Enhancing Type I Photochemistry in Photodynamic Therapy Under Near Infrared Light by Using Antennae–Fullerene Complexes

Huang

Liu

et al. 2018

Cytometry Pt A

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Photodynamic therapy (PDT) has been developed as salvage or palliative treatment for a wide range of tumors. The principle underlying this therapy is the generation of reactive oxygen species through two types of photochemical pathways. As compared with the type II pathway, the type I pathway offers a higher oxidizing ability for photosensitive residues such as tryptophan, lower oxygen dependency, and deeper tissue penetration ability. In this review, we focus on the enhancement of the type I pathway in the near infrared (NIR) optical therapeutic window of wavelength 700-1,100 nm by using antennae-fullerene complexes. When photo-induced electron transfer occurs from antennas to fullerene, the pathway switches from type II to type I. Enhancing the type I pathway leads to less oxygen dependency and stronger capacity for tryptophan oxidation. Then, antennae that transfer long-wavelength light (e.g., NIR light) energy to fullerene via photo-induced energy and/or electron transfer have the ability to affect deep-seated tumors. On the basis of theories on photo-induced energy/electron transfer in other fields such as solar cells, here, we summarize the mechanism by which the switch from the type II to type I pathway occurs in antenna-fullerene-based PDT.

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Photodynamic therapy as salvage therapy for patients with nasopharyngeal carcinoma experiencing local failures following definitive radiotherapy

Cited by 23 publications

References 22 publications

Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions

Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions

Novel Therapies Boosting T Cell Immunity in Epstein Barr Virus-Associated Nasopharyngeal Carcinoma

Enhancing Type I Photochemistry in Photodynamic Therapy Under Near Infrared Light by Using Antennae–Fullerene Complexes

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