Photodynamic Therapy Dosimetry: A Task Group Report of the General Medical Physics Committee of the Science Council

Hetzel, Fred W.; Brahmavar, S.M.; Chen, Qun; Jacques, Steven L.; Patterson, Michael S.; Wilson, Brian C.; Zhu, Timothy C.

doi:10.37206/89

Cited by 4 publications

(3 citation statements)

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“…In our original review paper (Wilson and Patterson 1986), we described the radiation transport equation (RTE) and the necessary interaction coefficients. Here, we briefly update that discussion to use currently recommended nomenclature and symbols (Hetzel et al 2005). For simplicity we assume that the light is monoenergetic (monochromatic), but the extension to a broad spectrum is straightforward (ignoring inelastic scattering and fluorescence).…”

Section: The Transport Equationmentioning

confidence: 99%

The physics, biophysics and technology of photodynamic therapy

2008

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Photodynamic therapy (PDT) uses light-activated drugs to treat diseases ranging from cancer to age-related macular degeneration and antibiotic-resistant infections. This paper reviews the current status of PDT with an emphasis on the contributions of physics, biophysics and technology, and the challenges remaining in the optimization and adoption of this treatment modality. A theme of the review is the complexity of PDT dosimetry due to the dynamic nature of the three essential components—light, photosensitizer and oxygen. Considerable progress has been made in understanding the problem and in developing instruments to measure all three, so that optimization of individual PDT treatments is becoming a feasible target. The final section of the review introduces some new frontiers of research including low dose rate (metronomic) PDT, two-photon PDT, activatable PDT molecular beacons and nanoparticle-based PDT.

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Section: The Transport Equationmentioning

confidence: 99%

The physics, biophysics and technology of photodynamic therapy

2008

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“…So, determining the singlet oxygen amount generated in the tissue can be considered an accurate value of the dose metric to guide treatments and predict their outcome. Many studies state that the necrosis threshold photodynamic dose threshold (PDD T ) is 10 17 to 10 19 1 O 2 /cm 3 9–12 …”

Section: Introductionmentioning

confidence: 99%

“…Many studies state that the necrosis threshold photodynamic dose threshold (PDD T ) is 10 17 to 10 19 1 O 2 /cm 3 . [9][10][11][12] There are three main approaches to determining the 1 O 2 production in tissue as a dose metric and PDT dose as follows: direct PDT dosimetry, explicit dosimetry, and implicit dosimetry. 13 Explicit dosimetry -depends on the continuous measurement of each factor interdependently during the PDT treatment.…”

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confidence: 99%

Optimizing the administrated light dose during 5‐ALA‐mediated photodynamic therapy: Murine 4T1 breast cancer model

Amiri,

Mokhtari‐Dizaji,

Mozdarani

2023

Photoderm Photoimm Photomed

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Photodynamic therapy (PDT) is already used to treat many cancers, including breast cancer, the most common cancer in women worldwide. The destruction basis of this method is on produced singlet oxygen which is extremely reactive and is a major agent of tumor cell killing. The measurement of singlet oxygen produced within PDT is essential in predicting treatment outcomes and their optimization. This study aims to determine the optimal total light dose administered during PDT by calculating the singlet oxygen to facilitate the prediction of the treatment outcome in mice bearing 4T1 cell breast cancer. Monitoring the changes in photosensitizer fluorescence signals during PDT due to photobleaching can be one of the methods of determination of singlet oxygen generation in the PDT process. This study determined the oxygen singlet as a photodynamic dose from the three‐dimensional Monte Carlo method and the photobleaching empirical dose constant. The photobleaching dose constant was established non‐invasively by monitoring the in vivo protoporphyrin IX (PpIX) fluorescence and photobleaching during PDT. The photobleaching dose constant (β) in J/cm2 was calculated using empirical fluorescence data. The in vivo photobleaching dose constant of aminolevulinic acid was found to be 11.6 J/cm2 and based on this value, the optimal treatment light dose was estimated at 120 J/cm2 in mice bearing 4T1 breast cancer. It is concluded that information can be obtained regarding optimal treatment parameters by monitoring the in vivo PpIX fluorescence and photobleaching during PDT.

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Photodynamic Therapy – the Quest for Improved Dosimetry in the Management of Solid Tumors

Johansson¹,

Andersson‐Engels

2010

Laser Imaging and Manipulation in Cell Biology

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Photodynamic Therapy Dosimetry: A Task Group Report of the General Medical Physics Committee of the Science Council

Cited by 4 publications

References 0 publications

The physics, biophysics and technology of photodynamic therapy

The physics, biophysics and technology of photodynamic therapy

Optimizing the administrated light dose during 5‐ALA‐mediated photodynamic therapy: Murine 4T1 breast cancer model

Photodynamic Therapy – the Quest for Improved Dosimetry in the Management of Solid Tumors

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