Photodynamic therapy for hypoxic tumors: Advances and perspectives

Huang, Li; Zhao, Shaojing; Wu, Jiasheng; Yu, Le; Singh, Nem; Yang, Ke; Lan, Minhuan; Wang, Pengfei; Kim, Jong Seung

doi:10.1016/j.ccr.2021.213888

Cited by 229 publications

(126 citation statements)

References 138 publications

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“…[222,223] PDT is limited by hypoxic characteristics of tumor tissues, which greatly limits therapeutic effect of hypoxic tumors. [224] PTT enhanced oxygen supply of tumor tissue by increasing blood flow of tumor tissue, so as to promote the therapeutic effect of PDT. At the same time, PDT can kill heat-resistant tumor cells, realizing synergistic enhancement therapy between PTT and PDT.…”

Section: Combination Therapymentioning

confidence: 99%

PEG‐Polymer Encapsulated Aggregation‐Induced Emission Nanoparticles for Tumor Theranostics

Dai

Dong

Wang

et al. 2021

Adv Healthcare Materials

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In the field of tumor imaging and therapy, the aggregation-caused quenching (ACQ) effect of fluorescent dyes at high concentration is a great challenge. In this regard, the aggregation-induced emission luminogens (AIEgens) show great potential, since AIEgens effectively overcome the ACQ effect and have better fluorescence quantum yield, photobleaching resistance, and photosensitivity. Polyethylene glycol (PEG)-polymer is the most commonly used carrier to prepare nanoparticles (NPs). The advantage of PEGylation is that it can greatly prolong the metabolic half-life and reduce immunogenicity and toxicity. Considering that the hydrophobicity of most AIEgens hinders their application in organisms, the use of PEG-polymer encapsulation is an effective strategy to overcome this obstacle. Importantly, bioactive functional groups can be modified on PEG-polymers to enhance the biological effect of NPs. The combination of powerful AIEgens and PEG-polymers provides a new strategy for tumor imaging and therapy, which is promising for clinical application.

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Section: Combination Therapymentioning

confidence: 99%

PEG‐Polymer Encapsulated Aggregation‐Induced Emission Nanoparticles for Tumor Theranostics

Dai

Dong

Wang

et al. 2021

Adv Healthcare Materials

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“…Yet, the typical sign of the tumor microenvironment is hypoxia. The rupture of blood vessels reduces the supply of oxygen to tumor tissues, and PDT needs to consume oxygen, which further deepens the hypoxia of tumor tissues, thereby inhibiting the efficiency of PDT [60]. Therefore, various methods have been developed to solve this problem, such as (1) O 2 supplement strategy, which uses high dissolved oxygen carriers to deliver oxygen to tumor tissues;…”

Section: Pdtmentioning

confidence: 99%

The Current Status of Chlorin e6-Based Nanoscale Delivery Systems for Cancer Therapy

Li¹,

Qiu²

2021

Oncologie

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Improving the effectiveness of cancer treatment has become a central concern for the public. In recent years, in order to maximize the efficiency of cancer treatment, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have received widespread attention. Chlorin e6 (Ce6) is a fluorescent dye with strong optical properties and excellent photoconversion efficiency under near-infrared light irradiation, which has been widely used in PDT in recent decades due to its superior antitumor ability. Of note, Ce6 can be used as a sonosensitizer for SDT, which generates large amounts of reactive oxygen species (ROS) for tumor treatment after ultrasound activation. These strategies can selectively kill local tumors without endangering normal tissues. At present, there are more and more researches on optimizing the pharmacological properties of Ce6-based therapeutic agents. Therefore, this review focuses on the properties of Ce6 and the research progress of various nano-scale delivery strategies based on Ce6 in tumor treatment. At last, we summarized the positive impact and bright prospects of Ce6-based nanomaterials in cancer treatment applications.

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“…[ 4 ] Clinical data, which are supported by results from preclinical experiments using animals, have shown that PDT can be synergistically paired with chemotherapy to achieve promising therapeutic effects. [ 5 ] PDT can effectively overcome drug resistance by sensitizing cancer cells for chemotherapy, activating the immune response, and preventing tumor angiogenesis. Additionally, PDT can help to reduce toxic side effects as well as the need for other anticancer drugs.…”

Section: Introductionmentioning

confidence: 99%

A Sequential Dual‐Model Strategy Based on Photoactivatable Metallopolymer for On‐Demand Release of Photosensitizers and Anticancer Drugs

Wang

et al. 2021

Advanced Science

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The synergistic combination of chemotherapy and photodynamic therapy has attracted considerable attention for its enhanced antitumoral effects; however, it remains challenging to successfully delivery photosensitizers and anticancer drugs while minimizing drug leakage at off-target sites. A red-light-activatable metallopolymer, Poly(Ru/PTX), is synthesized for combined chemo-photodynamic therapy. The polymer has a biodegradable backbone that contains a photosensitizer Ru complex and the anticancer drug paclitaxel (PTX) via a singlet oxygen ( 1 O 2 ) cleavable linker. The polymer self-assembles into nanoparticles, which can efficiently accumulate at the tumor sites during blood circulation. The distribution of the therapeutic agents is synchronized because the Ru complex and PTX are covalently conjugate to the polymer, and off-target toxicity during circulation is also mostly avoided. Red light irradiation at the tumor directly cleaves the Ru complex and produces 1 O 2 for photodynamic therapy. Sequentially, the generated 1 O 2 triggers the breakage of the linker to release the PTX for chemotherapy. Therefore, this novel sequential dual-model release strategy creates a synergistic chemo-photodynamic therapy while minimizing drug leakage. This study offers a new platform to develop smart delivery systems for the on-demand release of therapeutic agents in vivo.

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Photodynamic therapy for hypoxic tumors: Advances and perspectives

Cited by 229 publications

References 138 publications

PEG‐Polymer Encapsulated Aggregation‐Induced Emission Nanoparticles for Tumor Theranostics

PEG‐Polymer Encapsulated Aggregation‐Induced Emission Nanoparticles for Tumor Theranostics

The Current Status of Chlorin e6-Based Nanoscale Delivery Systems for Cancer Therapy

A Sequential Dual‐Model Strategy Based on Photoactivatable Metallopolymer for On‐Demand Release of Photosensitizers and Anticancer Drugs

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