Personalized nanomedicine is a revolutionary direction in healthcare, combining the achievements of nanotechnology with the principles of an individualized approach to treatment. This study analyzes the current state and prospects for the development of nanomedicine, including the use of AI in the management of nanorobots and the development of neural interfaces. Special attention is paid to the ethical and legal aspects of the safety of the use of nanotechnology in medicine. Based on a comprehensive analysis, recommendations are proposed for overcoming technological, ethical and regulatory challenges to ensure the safe and effective implementation of nanotechnology in clinical practice