Photodynamic therapy for rheumatoid arthritis?

Hendrich, Christian; Siebert, W.

doi:10.1002/(sici)1096-9101(1997)21:4<359::aid-lsm7>3.0.co;2-p

Cited by 17 publications

(6 citation statements)

References 18 publications

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“…Similar efforts to develop PDT as a technique to ablate inflamed synovium have been undertaken by Hendrich et al . using alternative first and second generation photosensitizers in a rabbit model of RA 12−15 . These authors have demonstrated that selective destruction of inflamed synovium is possible with PDT, but did not have a method to accurately quantify the uptake of photosensitizer into periarticular tissues.…”

Section: Discussionmentioning

confidence: 99%

Synovial ablation in a rabbit rheumatoid arthritis model using photodynamic therapy

Beischer

Bhathal

Steiger

et al. 2002

ANZ Journal of Surgery

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Section: Discussionmentioning

confidence: 99%

Synovial ablation in a rabbit rheumatoid arthritis model using photodynamic therapy

Beischer

Bhathal

Steiger

et al. 2002

ANZ Journal of Surgery

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“…However, other organic molecules can be envisaged. This was demonstrated by Hendrich and co-workers [61]. In this study, they have followed the same in vitro procedure as the one they used with Photosan-3 [38].…”

Section: Photosensitizers Used To Treat Rheumatoid Arthritismentioning

confidence: 98%

Photosensitizers Used in the Photodynamic Therapy of Rheumatoid Arthritis

Gallardo-Villagrán

Léger

Liagre

et al. 2019

IJMS

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Photodynamic Therapy (PDT) has become one of the most promising treatment against autoimmune diseases, such as rheumatoid arthritis (RA), as well as in the treatment of different types of cancer, since it is a non-invasive method and easy to carry out. The three main ingredients of PDT are light irradiation, oxygen, and a photosensitizer (PS). Light irradiation depends on the type of molecule or compound to be used as a PS. The concentration of O2 fluctuates according to the medium where the target tissue is located and over time, although it is known that it is possible to provide oxygenated species to the treated area through the PS itself. Finally, each PS has its own characteristics, the efficacy of which depends on multiple factors, such as solubility, administration technique, retention time, stability, excitation wavelength, biocompatibility, and clearance, among others. Therefore, it is essential to have a thorough knowledge of the disease to select the best PS for a specific target, such as RA. In this review we will present the PSs used in the last three decades to treat RA under PDT protocol, as well as insights on the relevant strategies.

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“…Since then, many investigators have studied photodynamic therapy for a variety of malignancies including those found in the lung, esophagus, colon, peritoneum, pleura, genitourinary tract, brain, eye, and skin 5–10 . Also, nononcologic conditions, including atherosclerosis, infectious diseases, and rheumatoid arthritis, have been investigated utilizing photodynamic therapy 11–14 …”

Section: Peer‐reviewed Reports For Dermatologic Conditions Treated mentioning

confidence: 99%

“…[5][6][7][8][9][10] Also, nononcologic conditions, including atherosclerosis, infectious diseases, and rheumatoid arthritis, have been investigated utilizing photodynamic therapy. [11][12][13][14] Because of the skin's accessibility to light sources, a great deal of research has been focused on the various dermatologic applications that may be amenable to photodynamic therapy treatment. Photodynamic therapy in dermatology has great promise because an appropriate photosensitizer or precursor of the photosensitizer can be accumulated selectively in either dystrophic skin cells or sebaceous glands.…”

Section: Drs Gold and Goldman Are Consultants Formentioning

confidence: 99%