Photodynamic Therapy for Treatment of Disease in Children—A Review of the Literature

Mazur, Artur; Koziorowska, Katarzyna; Dynarowicz, Klaudia; Aebisher, David; Bartusik‐Aebisher, Dorota

doi:10.3390/children9050695

Cited by 5 publications

(5 citation statements)

References 82 publications

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“…35 A 2022 systematic review of 81 studies found that PDT was a safe and effective treatment for various cutaneous and non-cutaneous diseases in the pediatric population. 36 Valladares et al's prospective trial reported complete remission of HS with PDT in 29/38 adult patients. 37 However, a recent systematic review found that most studies examining the use of standard PDT protocols in HS are of poor quality and carry a high risk of bias.…”

Section: Discussionmentioning

confidence: 99%

“…In PDT, a photosensitizing substance such as aminolevulinic acid is used concomitantly with a light source to create reactive oxygen species which may result in cell death and the eradication of bacterial biofilms 35 . A 2022 systematic review of 81 studies found that PDT was a safe and effective treatment for various cutaneous and non‐cutaneous diseases in the pediatric population 36 . Valladares et al's prospective trial reported complete remission of HS with PDT in 29/38 adult patients 37 .…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of procedural treatments for pediatric hidradenitis suppurativa: A systematic review

Masson

Parvathala

et al. 2023

Pediatric Dermatology

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Hidradenitis suppurativa (HS) is a painful, inflammatory skin disease that has historically been understudied in the pediatric population. Procedural interventions, such as surgical excisions, skin grafts, and lasers, are important for comprehensive HS disease management. However, there is a lack of data on procedural treatments for HS in pediatric patients. The purpose of this study was to conduct a systematic review of the literature on the efficacy and safety of procedural treatments for HS in pediatric patients. In April 2022, MEDLINE and EMBASE databases were searched for articles on the efficacy of procedural treatments for HS in patients <18 years of age. Two independent reviewers extracted data from relevant studies. From 1974 to 2021, 23 articles with 81 patients were identified. Patients' Hurley stages included stage I (9.1%, 1/11), II (36.4%, 4/11), and III (54.5%, 6/11). The most extensively studied procedural interventions include negative pressure wound therapy (n = 30), surgical excision with skin graft/flap (n = 19),and endoscopic electrode or laser treatment (n = 11). In all, promising response rates for procedural management strategies were observed in the literature but the findings were largely based on case reports/series. Randomized controlled trials (RCTs), especially those geared toward minimally invasive procedural treatments, are needed to help guide clinicians on the most efficacious treatment modalities for pediatric patients with HS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy of procedural treatments for pediatric hidradenitis suppurativa: A systematic review

Masson

Parvathala

et al. 2023

Pediatric Dermatology

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“…The selection and use of non-toxic PSs, concentration of the PS, and light dosage limit its use in children. Photosensitizers administered intravenously can be very uncomfortable in young patients [176].…”

Section: Limitations Of Apdt In the Clinicsmentioning

confidence: 99%

Photodynamic Therapy Applications in Cancer, Infections and Cardiovascular Disease

F Isaac-Lam,

Nguyen

2023

TTU J Biomed Sci

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Photodynamic therapy (PDT) or light treatment is a procedure to treat certain types of diseases that uses a photosensitizer (PS) which upon light activation produces cytotoxic oxygen species destroying tumor cells. PDT is minimally-invasive and can be repeated a few times without accumulating significant toxicity in the surrounding tissues. While PDT application in cancer treatment is well established and widely recognized by the scientific community, and its use in the fight against microbial infection is gaining momentum with the rapid increase in antimicrobial multi-drug resistance, its use in the treatment of cardiovascular diseases is clearly marginal. This mini-review presents a brief historical background of PDT, photo-activatable agents utilized, mechanism of photodynamic action, studies in vitro and in vivo, clinical trials, limitations and future prospects of its application in various types of cancer, infections caused by pathogens such as COVID-19, and heart diseases.

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“…The challenge to find DNA binding molecules that do not interfere with the functions of normal cells and/or to overcome multidrug resistance to chemotherapeutics is the most desirable goal. In this direction, due to the high spatial and temporal control, photochemotherapy [22][23][24] and photodynamic therapy [25][26][27][28] allow the minimally invasive treatment of several kinds of cancer and other nonmalignant diseases. Such impressive selectivity is due to the role of light, which acts as a counterpart to small organic molecules that can be excited by the energy offered by light and affect the biological target.…”

Section: Introductionmentioning

confidence: 99%

Effect of Arylazo Sulfones on DNA: Binding, Cleavage, Photocleavage, Molecular Docking Studies and Interaction with A375 Melanoma and Non-Cancer Cells

Mikra

Mitrakas

Ghizzani

et al. 2023

IJMS

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A set of arylazo sulfones, known to undergo N–S bond cleavage upon light exposure, has been synthesized, and their activity in the dark and upon irradiation towards DNA has been investigated. Their interaction with calf-thymus DNA has been examined, and the significant affinity observed (most probably due to DNA intercalation) was analyzed by means of molecular docking “in silico” calculations that pointed out polar contacts, mainly via the sulfonyl moiety. Incubation with plasmid pBluescript KS II revealed DNA cleavage that has been studied over time and concentration. UV-A irradiation considerably improved DNA damage for most of the compounds, whereas under visible light the effect was slightly lower. Moving to in vitro experiments, irradiation was found to slightly enhance the death of the cells in the majority of the compounds. Naphthylazosulfone 1 showed photo-disruptive effect under UV-A irradiation (IC50 ~13 μΜ) followed by derivatives 14 and 17 (IC50 ~100 μΜ). Those compounds were irradiated in the presence of two non-cancer cell lines and were found equally toxic only upon irradiation and not in the dark. The temporal and spatial control of light, therefore, might provide a chance for these novel scaffolds to be useful for the development of phototoxic pharmaceuticals.

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Photodynamic Therapy for Treatment of Disease in Children—A Review of the Literature

Cited by 5 publications

References 82 publications

Efficacy of procedural treatments for pediatric hidradenitis suppurativa: A systematic review

Efficacy of procedural treatments for pediatric hidradenitis suppurativa: A systematic review

Photodynamic Therapy Applications in Cancer, Infections and Cardiovascular Disease

Effect of Arylazo Sulfones on DNA: Binding, Cleavage, Photocleavage, Molecular Docking Studies and Interaction with A375 Melanoma and Non-Cancer Cells

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