Photodynamic therapy in colorectal cancer treatment: The state of the art in clinical trials

Kawczyk‐Krupka, Aleksandra; Bugaj, Andrzej M.; Latos, Wojciech; Zaremba, Katarzyna; Wawrzyniec, Katarzyna; Sieroń, Aleksander

doi:10.1016/j.pdpdt.2015.04.004

Cited by 87 publications

(57 citation statements)

References 22 publications

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“…Even though numerous advances have been made in relation to early diagnosis and treatment of CRC, tumor reoccurrence and metastatic spread are two critical factors which affect the survival rate of patients [6]. Dependent on the stage at which they have been diagnosed, approximately 25% of patients with CRC at time of diagnosis have metastases (due to late detection) and 50% of patients diagnosed with CRC will develop metastases, either at presentation or during follow-up [7,8].…”

Section: Introduction: Colorectal Cancer (Crc)mentioning

confidence: 99%

Targeted Photodynamic Therapy as Potential Treatment Modality for the Eradication of Colon Cancer

Kruger¹,

Abrahamse²

2019

Multidisciplinary Approach for Colorectal Cancer

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Photodynamic therapy (PDT) can be used to treat colorectal cancer (CRC). When a photosensitizer (PS) drug is administered to a patient, it can either passively or actively accumulate within a tumor site and once exposed to a specific wavelength of light, it is excited to produce reactive oxygen species (ROS), resulting in tumor destruction. However, the efficacy of ROS generation for tumor damage is highly dependent on the uptake of the PS in tumor cells. Thus, PS targeted uptake and delivery in CRC tumor cells is a crucial factor in PDT cancer drug absorption studies. Generally, within non-targeted drug delivery mechanisms, only minor amounts of PS passively accumulate in tumor sites and the remainder distributes into healthy tissues, causing unwanted side effects. To improve the efficacy of PDT research is currently focused on the development of specific receptor based photosynthetic nanocarrier platform drugs, which promote the active uptake and absorption of PS drugs in CRC tumor sites only, avoiding unwanted side effects, as well as treatment enhancement. This chapter will focus on current actively targeted PS nanoparticle drug delivery systems, which have been investigated for the PDT treatment of CRC cancer.

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Section: Introduction: Colorectal Cancer (Crc)mentioning

confidence: 99%

Targeted Photodynamic Therapy as Potential Treatment Modality for the Eradication of Colon Cancer

Kruger¹,

Abrahamse²

2019

Multidisciplinary Approach for Colorectal Cancer

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“…Colorectal cancer is associated with a high risk of metastasis and recurrence despite an increased availability of diagnostic and therapeutic strategies. To treat patients with colorectal cancer, an approach that selectively targets cancer cells without damaging normal cells and which minimizes the risk of perforating the intestinal barrier is needed (2).…”

Section: Introductionmentioning

confidence: 99%

p62 manipulation affects chlorin�e6‑mediated photodynamic therapy efficacy in colorectal cancer cell lines

Kim

2020

Oncol Lett

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p62 is a multifunctional protein that mediates cell signaling pathways, autophagy and tumorigenesis, and participates in important regulation processes at the intersection between autophagy and cancer. Photodynamic therapy (PDT) is a treatment that involves photosensitizing agents and light to kill cancer cells. However, whether the efficacy of PDT depends on the expression level of p62 in colorectal cancer cell lines is not known. The present study aimed to examine the role of p62 expression levels in chlorin e6-based PDT in colorectal cancer cells. To study the effect of p62 on cancer cell death, we used PDT to treat a stable cell line overexpressing p62. Cells overexpressing p62 showed a higher cell death rate than cells not expressing this protein. Overexpression of p62 may contribute to colorectal cancer cell death. These results provide preliminary evidence for use of p62 as a therapy target to treat colorectal cancer.

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“…Photodynamic therapy is a clinically approved, minimally invasive therapeutic procedure that exerts selective cytotoxic activity toward malignant cells. The procedure involves the administration of a photosensitizing agent (photosensitizer) followed by irradiation at a wavelength corresponding to an absorbance band of the photosensitizer, leading to the generation of reactive oxygen species (ROS) to promote the death of malignant cell, infectious agents, and removal of burns . PDT has numerous advantages over typical cancer treatment, such as surgery, chemotherapy, and radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Silk fibroin hydrogels for potential applications in photodynamic therapy

et al. 2018

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In this study, we prepared translucid hydrogels with different concentrations of silk fibroin, extracted from raw silk fibers, and used them as a matrix to incorporate the photosensitizer 5-(4-aminophenyl)-10,15,20-tris-(4-sulphonatophenyl) porphyrin trisodium for application in photodynamic therapy (PDT). The hydrogels obtained were characterized by rheology, spectrophotometry, and scattering techniques to elucidate the factors involved in the formation of the hydrogel, and to characterize the behavior of silk fibroin (SF) after incorporating of the porphyrin to the matrix. The rheology results demonstrated that the SF hydrogels had a shear thinning behavior. In addition, we were able to verify that the structure of the material was able to be recovered over time after shear deformation. The encapsulation of porphyrins in hydrogels leads to the formation of self-assembled peptide nanostructures that prevent porphyrin aggregation, thereby greatly increasing the generation of singlet oxygen. Also, our findings suggest that porphyrin can diffuse out of the hydrogel and permeate the outer skin layers. This evidence suggests that SF hydrogels could be used as porphyrin encapsulation and as a drug carrier for the sustained release of photosensitizers for PDT. K E Y W O R D Sfibroin, hydrogel, photodynamic therapy, porphyrin, rheology, singlet oxygen

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Photodynamic therapy in colorectal cancer treatment: The state of the art in clinical trials

Cited by 87 publications

References 22 publications

Targeted Photodynamic Therapy as Potential Treatment Modality for the Eradication of Colon Cancer

Targeted Photodynamic Therapy as Potential Treatment Modality for the Eradication of Colon Cancer

p62 manipulation affects chlorin�e6‑mediated photodynamic therapy efficacy in colorectal cancer cell lines

Silk fibroin hydrogels for potential applications in photodynamic therapy

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