Photodynamic therapy of 168 early stage cancers of the lung and oesophagus: a japanese multi-centre study

Hayata, Yoshihiro; Kato, Harubumi; Furuse, Kiyoyuki; Kusunoki, Yoko; Suzuki, S; Mimura, Seishiro

doi:10.1007/bf02134916

Cited by 39 publications

(24 citation statements)

References 9 publications

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“…The use of photodynamic therapy for treating early stage superficial squamous cell cancer in the central airways has increased awareness of the curative potential of local treatment [8,16,20]. Although this may sound incorrect from the perspective of histology classification, the accepted standard strategy of surgical resection has to be seen in the proper perspective, especially when dealing with severe comorbidities.…”

Section: Endoluminalmentioning

confidence: 99%

“…Higher response rates were correlated with tumour dimension, indicating the paramount importance of early detection and accurate staging [16,20,32]. Current abilities for accurate TNM staging in the early event of carcinogenesis, together with local intervention (e.g.…”

Section: Nonsurgical Candidatesmentioning

confidence: 99%

“…in the pre-neoplastic and carcinoma in situ stage. Certain individuals with favourable early lesions can be properly identified and a less invasive approach is appropriate in these subjects [13][14][15][16][17][18][19][20]. The time window before microinvasive cancer develops nodal involvement can be exploited by choosing a tailored approach for each particular lesion in the person at risk that better preserves QoL and has superior cost-effectiveness [21,22].…”

mentioning

confidence: 99%

“…Medically unfit patients with early stage cancer have been treated successfully with intraluminal bronchoscopic treatment (IBT) [16][17][18]. The future of accurate navigational technique, in combination with in vivo microdynamic imaging, can help to extend the reach towards early lesions in the lung parenchyma [23,24], as the majority of them are nonmalignant and tissue biopsy is still required prior to any treatment commencement [25].…”

mentioning

confidence: 99%

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Therapeutic bronchoscopy with immediate effect: laser, electrocautery, argon plasma coagulation and stents

Bolliger¹

2006

Eur Respir J

339

276

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Minimally invasive diagnostic and therapeutic approaches in medicine have been applied for a more selective and tailored approach to reduce patients' morbidity and mortality. The efficacy of interventional pulmonology for palliation of patients with central airways obstruction has been established and its curative potential for intralesional treatment of early cancer has raised great interest in current screening programmes. This is due to the fact that surgical resection and systemic nodal dissection as the gold standard is relatively morbid and risky, especially when dealing with individuals with limited functional reserves due to smoking-related comorbidities, such as chronic obstructive pulmonary disease. Furthermore, such comorbidities have been proven to harbour early stage lesions of several millimetres in size without involvement of nodal disease that may be amenable to local bronchoscopic treatment.Therefore, the success of minimally invasive strategies for palliation and treatment with curative intent strongly depends on the diligent identification of the various factors in lung cancer management, including full comprehension of the limits and potential of each particular technique. Maximal preservation of quality of life is a prerequisite in successfully dealing with individuals at risk of harbouring asymptomatic early lung cancer, to prevent aggressive surgical diagnostic and therapeutic strategies since overdiagnosis remains an issue that is heavily debated.In the palliative setting of alleviating central airway obstruction, laser resection, electrocautery, argon plasma coagulation and stenting are techniques that can provide immediate relief, in contrast to cryotherapy, brachytherapy and photodynamic therapy with delayed effects. With curative intent, intraluminal techniques that easily coagulate early stage cancer lesions will increase the implementation of interventional pulmonology for benign and relatively benign diseases, as well as early cancer lesions and its precursors at their earliest stage of disease.

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Section: Endoluminalmentioning

confidence: 99%

Section: Nonsurgical Candidatesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Therapeutic bronchoscopy with immediate effect: laser, electrocautery, argon plasma coagulation and stents

Bolliger¹

2006

Eur Respir J

339

276

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“…Photodynamic therapy (PDT) is emerging as a new form of cancer treatment with a potential for cure when applied to early-stage cancers (Monnier et al, 1990;Bown, 1993;Sibille et al, 1995;Barr et al, 1996;Grosjean et al, 1996;Hayata et al, 1996;Panjehpour, 1996;Cortese et al, 1997). With PDT, tissue destruction is achieved by administration of a photosensitizing chemical (PS) followed by delivery of light at a wavelength corresponding to one of the absorption peaks of the drug (Henderson and Dougherty, 1992;Fisher et al, 1995;Stables and Ash, 1995).…”

mentioning

confidence: 99%

Clinical photodynamic therapy for superficial cancer in the oesophagus and the bronchi: 514 nm compared with 630 nm light irradiation after sensitization with Photofrin II

Grosjean

Wagnières²,

Fontolliet³

et al. 1998

Br J Cancer

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Summary Photodynamic therapy (PDT) for cancer in the oesophagus and bronchi with red (630 nm) light may occasionally lead to wall perforation and fistula. Therefore, we investigated the clinical use of a less penetrating wavelength (514 nm) for the curative treatment of nine superficial carcinomas in the oesophagus and bronchi after photosensitization with Photofrin II. Tumours without infiltration beyond the submucosa in the oesophagus and beyond the lamina propria in the bronchi were considered as superficial cancers. The outcome and complications were compared with those of 13 superficial cancers treated with PDT and 630 nm light. In addition, we evaluated histologically the extent of the long-term tissue damage and scarring following treatment of six oesophageal cancers with either green or red light. At first endoscopic control, 7-10 days after PDT, tissue necrosis simply matched the illuminated area, without evidence of selective tumour damage. Six of nine tumours treated with 514 nm light had a complete response compared with nine of 13 after 630 nm irradiation. No perforation or fistula occurred in either treatment group. However, severe chest pain and fever with or without pleural effusion, consistent with occult perforation, were observed in three patients after 630 nm illumination in the oesophagus. Histologically, fibrous scarring in the three distinct sites treated with green light was limited to the superficial layers of the oesophagus. After red light treatment, transmural fibrosis with marked thinning of the oesophageal wall was evident in two of the three specimens available for inspection. These results indicate that PDT with 514 nm light has the potential to cure superficial cancer in the oesophagus and bronchi with essentially the same probability of success as red light. In the oesophagus, green light prevents deep tissue damage, thus reducing the risk of perforation.

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Bronchoscopic Interventions for Lung Cancer

Lazarus

Eapen

2014

Lung Cancer

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Photodynamic therapy of 168 early stage cancers of the lung and oesophagus: a japanese multi-centre study

Cited by 39 publications

References 9 publications

Therapeutic bronchoscopy with immediate effect: laser, electrocautery, argon plasma coagulation and stents

Therapeutic bronchoscopy with immediate effect: laser, electrocautery, argon plasma coagulation and stents

Clinical photodynamic therapy for superficial cancer in the oesophagus and the bronchi: 514 nm compared with 630 nm light irradiation after sensitization with Photofrin II

Bronchoscopic Interventions for Lung Cancer

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