Photodynamic therapy of cervical intraepithelial neoplasia

Inada, Natália Mayumi; Lombardi, Welington; Leite, Marieli Fernanda Martins; Trujillo, J Roberto; Kurachi, Cristina; Bagnato, Vanderlei Salvador

doi:10.1117/12.2040004

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…However, 3 proceedings records were found in Conference Proceedings Citation Index (CPCI) meeting our qualitative analysis criteria. [20–22] Among the 168 records identified from the Medline, EMBASE, Cochrane Central Register, and CPCI databases, 136 studies were screened after elimination of duplicate articles, and 70 full-text articles were retrieved after screening the title and abstract. After exclusion of 47 articles that were not relevant, 21 qualitative studies and 4 RCTs [23–26] were identified as meeting all the inclusion criteria (Supplementary S4).…”

Section: Resultsmentioning

confidence: 99%

“…For the analysis of a systematic review to verify the accuracy of our meta-analysis results, we identified 21 [4,8,20–22,28–43] eligible qualitative studies (Table 2) by screening the title and abstract of 16 qualitative articles, 42 reviews (listed in Supplementary S3) and 3 papers from CPCI; then, the information was summarized and data were extracted from these studies. Intriguingly, the CRR indicating PDT efficacy in patients with CIN ranged from 31.3% to 100%.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy and safety of photodynamic therapy for cervical intraepithelial neoplasia and human papilloma virus infection

Zhang

Sun

et al. 2018

Medicine

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of photodynamic therapy for cervical intraepithelial neoplasia and human papilloma virus infection

Zhang

Sun

et al. 2018

Medicine

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“…The photodynamic diagnosis was important to verify protoporphyrin IX (PpIX) production and its consumption by topical medication with MAL at 20% (w/w) in an oil/water cream, and it may help the physician to guarantee the complete PDT (Figure 2). MAL and aminolevulinic acid (ALA) produce the photosensitizer commonly used in PDT, protoporphyrin IX (PpIX), by mitochondria and it is a helpful tool to monitor the PpIX production and consumption during tissue illumination [17,18].…”

Section: Resultsmentioning

confidence: 99%

Long Term Effectiveness of Photodynamic Therapy for CIN Treatment

Inada

Buzzá

Leite³

et al. 2019

Pharmaceuticals

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(1) Background: Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in women worldwide. The highest incidence rates are in Africa, followed by South-Central Asia and South America. According to the Brazilian National Institute of Cancer (INCA), 16,370 new cases of cervical cancer were estimated for each year of the biennium of 2018–2019. About 90% of cervical cancers originate from the malignant progression of cervical intraepithelial neoplasia (CIN) which is classified based on cytohistological characteristics (low- and high-grade lesions). The present study reports the long-term effectiveness of topical photodynamic therapy (PDT) for CIN grades 1 and 2/3 with up to two years of follow up. (2) Methods: A total of 56 patients with CIN 1, ten with CIN 2, and 14 patients for the placebo group were enrolled in this study. (3) Results: 75% (n = 42) of CIN 1 patients presented a complete response to PDT and only 23.2% (n = 13) of recurrence, progression, and/or lesions remaining two years after PDT. For CIN 2/3 patients, 90% were observed to be cured after one and two years of follow up. (4) Conclusions: PDT presented best results two years after a non-invasive, fast, and low-cost procedure and in comparison with the placebo group, preventing the progression of cervical intraepithelial neoplasia and preserving the cervix.

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“…Photodynamic therapy for the treatment of onychomycosis has shown promising results [7,8,9,10,11,12]. In photodynamic therapy (PDT), a photosensitizing compound is activated by light and, in the presence of oxygen, leads to the production of several reactive oxygen species (ROS), inactivating microorganisms [13,14,15], inducing tumor cells death [16,17,18,19] and causing the death of other abnormal cells [20,21,22,23]. The great advantage of the technique for microorganism inactivation is the unlikely possibility of treatment selection of resistant microorganisms to several applications and minimum side effects comparing to systemically used oral drugs.…”

Section: Introductionmentioning

confidence: 99%

Raman Microspectroscopy as a Tool to Elucidate the Efficacy of Topical Formulations Containing Curcumin

Iermak

Silva²,

Kurachi

et al. 2019

Pharmaceuticals

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The success of the onychomycosis treatment is directly associated with factors such as the choice of the medication, the administration route, and the pharmaceutical formulation. Photodynamic therapy (PDT) is an emerging and promising technique indicated for onychomycosis treatment. For this application, the main challenge is the efficient delivery of the photosensitizer (PS). Curcumin is widely used as a PS, however it is an unstable molecule and it is a challenge to develop a formulation with good penetration into the nail plate, maintaining the stability of curcumin. In this study, the molecular mechanisms underlying the efficacy of two topical formulations containing curcumin used in a clinical trial for onychomycosis treatment were analyzed by Raman microspectroscopy. It is shown that curcumin is present in both formulations in aggregated and non-aggregated states, and in aggregates it is present in different conformations, depending on the interaction with the solvent. This proves to be critical for efficient and uniform PS delivery to the nail and its complete use during the treatment. These analyses are showing how promising Raman microspectroscopy is in understanding the molecular mechanisms of the efficiency of photosensitizers and are helping to improve the development of pharmaceutical formulations.

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Photodynamic therapy of cervical intraepithelial neoplasia

Cited by 3 publications

References 6 publications

Efficacy and safety of photodynamic therapy for cervical intraepithelial neoplasia and human papilloma virus infection

Efficacy and safety of photodynamic therapy for cervical intraepithelial neoplasia and human papilloma virus infection

Long Term Effectiveness of Photodynamic Therapy for CIN Treatment

Raman Microspectroscopy as a Tool to Elucidate the Efficacy of Topical Formulations Containing Curcumin

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