Photodynamic therapy of early esophageal cancer

Филоненко, Е. В.; Соколов, В. В.; Чиссов, В И; Luk’yanets, E. A.; Vorozhtsov, Georgy N.

doi:10.1016/j.pdpdt.2008.06.001

Cited by 61 publications

(27 citation statements)

References 6 publications

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“…PDT is a minimally invasive therapeutic modality which has been shown to be effective against different types of malignancies like skin and esophageal cancer. 8,9 PDT has some advantage in cancer treatments, it has a less invasive than surgery and radiotherapy. It has no long-term side effects when used properly and PDT can be repeated many times at the same site if needed.…”

Section: Discussionmentioning

confidence: 99%

Effect of Photodynamic Therapy in Melanoma Skin Cancer Cell Line A375: in vivo Study

et al. 2014

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Background and ObjectivesAminolevulinic acid (ALA), a precursor of heme, which is converted to protoporphyrin IX, is used as an effective photosensitizer. The aim of this study is to evaluate the effect of photodynamic therapy (PDT) using 5-ALA in an in vivo experiment using melanoma skin cancer cell line A375. Materials and MethodsFemale nude mice (BALB/C/nu/nu), four weeks of age and 25-30 g (Narabio, Korea) in weight, were used in the study. When the actual tumor size reached more than 100-200 mm 3 , the mice were divided randomly into the PDT group (n = 7), LED (light emitting diode) group (n = 3), ALA group (n = 3), and control group (n = 7). ALA 375 mg/kg was used in the study as an intraperitoneally injected photosensitizer. The tumors were then irradiated using a 630 nm LED for 30 min after 3 hours in a dark room. Tumor dimensions were measured using a caliper at 0, 7, 14, 21, and 28 days after treatment in all groups and tumor volume was calculated. ResultsThere was no significant difference in the mean tumor volumes on 0 day before treatment in each group (p>0.05). However, significant differences in the mean tumor volumes were observed between the PDT and control groups at 7, 14, 21, and 28 days after treatment (p<0.05). ConclusionALA mediated PDT was found to be effective in melanoma skin cancer cell A375 induced tumor xenograft in nude mice.

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Section: Discussionmentioning

confidence: 99%

Effect of Photodynamic Therapy in Melanoma Skin Cancer Cell Line A375: in vivo Study

et al. 2014

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“…In another study, early stage non-obstructing esophageal carcinoma was treated using less purified porphyrin preparations or ALA, yielding complete response rates of 50%-80% respectively [12]. In a clinical trial just published by a Russian group [14], 48 patients with early esophageal cancer, diagnosed in the course of endoscopical investigation for non-oncological diseases, were treated using different sentitizers: (Photogem ® , Photosens ® ) and irradiation was performed using a diode laser with appropriate wavelength for each drug. After the first session, 32 patients showed complete regression, and total remission was obtained in 37 cases after 2-4 repeated treatments.…”

Section: Pdt In Clinical Practicementioning

confidence: 99%

A look at clinical applications and developments of photodynamic therapy

et al. 2008

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The battle against cancer is so important that all possible weapons must be considered. Photodynamic therapy (PDT) is a therapeutic approach which has proved its capacity to give many excellent results, but it is having some difficulty in being imposed. The simplicity of the mechanism of action of this technique has been compromised by the multidisciplinary approach required for its implementation, which makes its adoption for more general use by health professionals difficult. This review aims to give a perspective of the performance of current approved PDT drugs, and their clinical applications against cancer.Basic investigation in PDT, particularly in the design of new sensitizers, is still ongoing, and needs to be further exploited. Emergent and diversified solutions with excellent results in pre-clinical phases are described to raise the multidisciplinary interest required to boost the clinical use of PDT.

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“…[7,8] Photosensitizing properties are successfully used in photodynamic therapy of cancer. [9,10] But at the same time the clinical potential and the mechanism of dark cytostatic/cytotoxic activity of those compounds haven't been studied enough.…”

Section: Introductionmentioning

confidence: 99%