Photodynamic therapy of tumors with pyropheophorbide-&lt;em&gt;a&lt;/em&gt;-loaded polyethylene glycol&amp;ndash;poly(lactic-&lt;em&gt;co&lt;/em&gt;-glycolic acid) nanoparticles

Liu, Hui; Zhao, Mei; Wang, Jin; Pang, Mingpei; Wu, Zhenzhou; Zhao, Liqing; Yin, Zhinan; Hong, Zhangyong

doi:10.2147/ijn.s112541

Cited by 15 publications

(1 citation statement)

References 39 publications

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“…In recent years, increasing number of researchers have designed PS loading DDSs and proved these DDSs could help reduce light-associated toxicity and enhance the drug accumulation. Various kinds of nanocarriers have been developed for the more specific drug delivery and better biocompatibility, such as lipidbased nanoparticles, calcium phosphate nanoparticles, magnetic nanoparticles and other copolymer nano-carriers (Wang, Fei, et al, 2014;Haedicke et al, 2015;He et al, 2015;Hong et al, 2016).…”

Section: Light-responsive Ddssmentioning

confidence: 99%

Stimuli-responsive drug delivery systems for head and neck cancer therapy

et al. 2021

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Head and neck cancer (HNC) is among the most common malignancy that has a profound impact on human health and life quality. The treatment for HNC, especially for the advanced cancer is stagedependent and in need of combined therapies. Various forms of adjuvant treatments such as chemotherapy, phototherapy, hyperthermia, gene therapy have been included in the HNC therapy. However, there are still restrictions with traditional administration such as limited in situ therapeutic effect, systemic toxicity, drug resistance, etc. In recent years, stimuli-responsive drug delivery systems (DDSs) have attracted the great attention in HNC therapy. These intelligent DDSs could respond to unique tumor microenvironment, external triggers or dual/multi stimulus with more specific drug delivery and release, leading to enhanced treatment efficiency and less reduced side effects. In this article, recent studies on stimuli-responsive DDSs for HNC therapy were summarized, which could respond to endogenous and exogenous triggers including pH, matrix metalloproteinases (MMPs), reactive oxygen species (ROS), redox condition, light, magnetic field and multi stimuli. Their therapeutic remarks, current limits and future prospect for these intelligent DDSs were discussed. Furthermore, multifunctional stimuli-responsive DDSs have also been reviewed. With the modification of drug carriers or co-loading with therapeutic agents. Those intelligent DDSs showed more biofunctions such as combined therapeutic effects or integration of diagnosis and treatment for HNC. It is believed that stimuli-responsive drug delivery systems showed great potential for future clinic translation and application for the treatment of HNC.

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Section: Light-responsive Ddssmentioning

confidence: 99%

Stimuli-responsive drug delivery systems for head and neck cancer therapy

et al. 2021

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Adipocyte‐Derived Anticancer Lipid Droplets

et al. 2021

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Engineering of efficient and safe materials remains a challenge for cancer therapy. Here, the lipid droplet, an organelle in adipocytes, is demonstrated to be a controllable and biocompatible vehicle to deliver anticancer drugs. It is validated that isolated lipid droplets maintain their key physiological functions to interact with other organelles and augment the therapeutic effect of cancer photodynamic therapy by encapsulation with a lipid‐conjugated photosensitizer (Pyrolipid) through a variety of pathways, including generation of reactive oxygen species (ROS); lipid peroxidation; and endoplasmic reticulum (ER) stress. As such, the IC50 value of Pyrolipid is reduced by 6.0‐fold when loaded into the lipid droplet. Of note, in vivo results demonstrate that engineered lipid droplets induce significant inhibition of tumor growth with minimal side effects.

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