Photodynamic therapy platform for glioblastoma and intrabronchial tumors

Orsila, Lasse; Alanko, Jukka-Pekka; Kaivosoja, Visa; Uibu, Toomas

doi:10.1117/12.2297229

Cited by 1 publication

(1 citation statement)

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“…The launch points of photon packets were located inside the radiation section of the inserted cylindrical light diffuser according to Saccomandi et al 36 As a laser source, a multiport laser system (ML 7710i, Modulight, Finland) with a wavelength of 635 nm and eight fiber ports was assumed. 37 Calculations of light propagation were performed for 1 × 10 7 photons. Irradiation time and irradiation power density were changed according to the simulation conditions.…”

Section: Light Propagation Calculationmentioning

confidence: 99%

Singlet oxygen model evaluation of interstitial photodynamic therapy with 5-aminolevulinic acid for malignant brain tumor

et al. 2019

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Interstitial photodynamic therapy (iPDT) with 5-aminolevulinic acid (ALA) is a possible alternative treatment for malignant brain tumors. Further evaluation is, however, required before it can be clinically applied. Computational simulation of the photophysical process in ALA-iPDT can offer a quantitative tool for understanding treatment outcomes, which depend on various variables related to clinical treatment conditions. We propose a clinical simulation method of ALA-iPDT for malignant brain tumors using a singlet oxygen (1 O 2) model and 1 O 2 threshold to induce cell death. In this method, the amount of 1 O 2 generated is calculated using a photosensitizer photobleaching coefficient and 1 O 2 quantum yield, which have been measured in several previous studies. Results of the simulation using clinical magnetic resonance imaging data show the need to specify the insertion positions of cylindrical light diffusers and the level of light fluence. Detailed analysis with a numerical brain tumor model demonstrates that ALA-iPDT treatment outcomes depend on combinations of photobleaching and threshold values. These results indicate that individual medical procedures, including pretreatment planning and treatment monitoring, will greatly benefit from simulation of ALA-iPDT outcomes. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Light Propagation Calculationmentioning

confidence: 99%