Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib

Sun, Xu; Cao, Ziyang; Mao, Kuirong; Wu, Chenxi; Chen, Hongmei; Wang, Jialiang; Wang, Xin; Cong, Xiuxiu; Li, Yong; Meng, Xiangchuan; Yang, Xianzhu; Yang, Yong‐Guang; Sun, Tianmeng

doi:10.1016/j.biomaterials.2020.119845

Cited by 69 publications

(56 citation statements)

References 43 publications

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“…The cascade-amplifying antitumor effects can be achieved from the release of sorafenib, low-dose PDT and subsequently systemic antitumor immune responses. 65 Including simple metal ions into co-assemblies could greatly enhance the corresponding combined treatments. For example, the co-assembly of 9-uorenylmethyloxycarbonyl-L-leucine (Fmoc-L-L) with ionic manganese (Mn 2+ ), as well as Ce6 forms biometal-organic nanoparticles, which exhibit a high drug loading capability, inherent good biocompatibility, robust stability, and smart disassembly in response to glutathione (GSH).…”

Section: Pdt Based On Co-assemblymentioning

confidence: 99%

Assembled small organic molecules for photodynamic therapy and photothermal therapy

et al. 2021

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Section: Pdt Based On Co-assemblymentioning

confidence: 99%

Assembled small organic molecules for photodynamic therapy and photothermal therapy

et al. 2021

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“…This combinatorial platform enabled the complete ablation of local and distant metastatic tumors. [ 83 ] In another attempt, Kim et al. designed a polyglutamic acid‐based nanoparticle platform for the photodynamic immunotherapy approach.…”

Section: Self‐assembled Multifunctional Nanomaterials For Combinatorimentioning

confidence: 99%

Engineered Multifunctional Nano‐ and Biological Materials for Cancer Immunotherapy

Brouillard

Deshpande

Kulkarni

2021

Adv Healthcare Materials

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Cancer immunotherapy is set to emerge as the future of cancer therapy. However, recent immunotherapy trials in different cancers have yielded sub‐optimal results, with durable responses seen in only a small fraction of patients. Engineered multifunctional nanomaterials and biological materials are versatile platforms that can elicit strong immune responses and improve anti‐cancer efficacy when applied to cancer immunotherapy. While there are traditional systems such as polymer‐ and lipid‐based nanoparticles, there is a wide variety of other materials with inherent and additive properties that can allow for more potent activation of the immune system. By synthesizing and applying multifunctional strategies, it allows for a more extensive and more effective repertoire of tools to use in the wide variety of situations that cancer presents itself. Here, several types of nanoscale and biological material strategies and platforms that provide their inherent benefits for targeting and activating multiple aspects of the immune system are discussed. Overall, this review aims to provide a comprehensive understanding of recent advances in the field of multifunctional cancer immunotherapy and trends that pave the way for more diverse and tactical regression of tumors through soliciting responses by either the adaptive or innate immune system, and even both simultaneously.

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“…Sun and coworkers recently reported a sorafenib and chlorin e6 (Ce6) co-loaded ROS-responsive nanoparticle to improve antitumor responses for PDT combinational immunotherapy ( Sun et al, 2020 ). Sorafenib is a small molecular multi-kinase inhibitor that inhibits the functions of immunosuppressive cells in tumor microenvironment, resulting in augmented antitumor immunity via enhancing the activities of tumor-specific cytotoxic T cells ( Chen et al, 2014 ).…”

Section: Photodynamic Activatable Immunomodulatory Nanoparticlesmentioning

confidence: 99%

Near-Infrared Photoactivatable Immunomodulatory Nanoparticles for Combinational Immunotherapy of Cancer

Ding

2021

Front. Chem.

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As a promising treatment option for cancer, immunotherapy can eliminate local and distant metastatic tumors and even prevent recurrence through boosting the body’s immune system. However, immunotherapy often encounters the issues of limited therapeutic efficacy and severe immune-related adverse events in clinical practices, which should be mainly due to the non-specific accumulations of immunotherapeutic agents. Activatable immunomodulatory agents that are responsive to endogenous stimuli in tumor microenvironment can afford controlled immunotherapeutic actions, while they still face certain extent of off-target activation. Since light has the advantages of noninvasiveness, simple controllability and high spatio-temporal selectivity, therapeutic agents that can be activated by light, particularly near-infrared (NIR) light with minimal phototoxicity and strong tissue penetrating ability have been programmed for cancer treatment. In this mini review, we summarize the recent progress of NIR photoactivatable immunomodulatory nanoparticles for combinational cancer immunotherapy. The rational designs, constructions and working mechanisms of NIR photoactivatable agents are first briefly introduced. The uses of immunomodulatory nanoparticles with controlled immunotherapeutic actions upon NIR photoactivation for photothermal and photodynamic combinational immunotherapy of cancer are then summarized. A conclusion and discussion of the existing challenges and further perspectives for the development and clinical translation of NIR photoactivatable immunomodulatory nanoparticles are finally given.

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Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib

Cited by 69 publications

References 43 publications

Assembled small organic molecules for photodynamic therapy and photothermal therapy

Assembled small organic molecules for photodynamic therapy and photothermal therapy

Engineered Multifunctional Nano‐ and Biological Materials for Cancer Immunotherapy

Near-Infrared Photoactivatable Immunomodulatory Nanoparticles for Combinational Immunotherapy of Cancer

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