Photodynamic therapy treatment of superficial fungal infections: A systematic review

Shen, Julia J; Jemec, Gregor B. E.; Arendrup, Maiken Cavling; Saunte, Ditte Marie Lindhardt

doi:10.1016/j.pdpdt.2020.101774

Cited by 78 publications

(50 citation statements)

References 52 publications

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“…Light applied intravenously can be a solution during the clinical treatment of infections. Very recently, the use of the PDT procedure to treat patients with COVID-19 has also been discussed [ 8 , 57 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 ].…”

Section: Applications Of Pdtmentioning

confidence: 99%

Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions

et al. 2021

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Photodynamic therapy (PDT) is a minimally invasive therapeutic modality that has gained great attention in the past years as a new therapy for cancer treatment. PDT uses photosensitizers that, after being excited by light at a specific wavelength, react with the molecular oxygen to create reactive oxygen species in the target tissue, resulting in cell death. Compared to conventional therapeutic modalities, PDT presents greater selectivity against tumor cells, due to the use of photosensitizers that are preferably localized in tumor lesions, and the precise light irradiation of these lesions. This paper presents a review of the principles, mechanisms, photosensitizers, and current applications of PDT. Moreover, the future path on the research of new photosensitizers with enhanced tumor selectivity, featuring the improvement of PDT effectiveness, has also been addressed. Finally, new applications of PDT have been covered.

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Section: Applications Of Pdtmentioning

confidence: 99%

Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions

et al. 2021

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“…PDT can be applied for disinfection and sterilization [4][5][6][7]. Microbial, including bacterium and viruses can be removed by photosensitized reaction.…”

Section: Electron Transfer Mechanism and Antimicrobial Photodynamic Tmentioning

confidence: 99%

“…This treatment is a medicinal application of photochemistry. Antimicrobial treatment, called as antimicrobial photodynamic therapy (aPDT) or photodynamic antimicrobial chemotherapy (PACT), is also important application [4][5][6][7]. In the case of cancer treatment, less-toxic PDT reagents, photosensitizers, cause oxidative damage to biomolecules, including protein, nucleic acids, and/or other compounds, under visible-light irradiation.…”

Section: Introductionmentioning

confidence: 99%

Electron Transfer-Supported Photodynamic Therapy

Hirakawa¹

2021

Photodynamic Therapy - From Basic Science to Clinical Research

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Photodynamic therapy (PDT) is a less-invasive treatment of cancer and precancerous lesions. Porphyrin derivatives have been used and studied as the photosensitizers for PDT. In general, the biomacromolecules oxidation by singlet oxygen, which is produced through energy transfer from the photoexcited photosensitizers to oxygen molecules, is an important mechanism of PDT. However, the traditional PDT effect may be restricted, because tumors are in a hypoxic condition and in certain cases, PDT enhances hypoxia via vascular damage. To solve this problem, the electron transfer-mediated oxidation of biomolecules has been proposed as the PDT mechanism. Specifically, porphyrin phosphorus(V) complexes demonstrate relatively strong photooxidative activity in protein damage through electron transfer. Furthermore, other photosensitizers, e.g., cationic free-base porphyrins, can oxidize biomolecules through electron transfer. The electron transfer-supported PDT may play the important roles in hypoxia cancer therapy. Furthermore, the electron transfer-supported mechanism may contribute to antimicrobial PDT. In this chapter, recent topics about the biomolecules photooxidation by electron transfer-supported mechanism are reviewed.

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“…PDT consists of the annihilation of several cancers, through an incident visible light (VL), which sensitizes a drug called photosensitizer (PS), causing damage to living tissue (cancer cells), occurring the production of oxygen in this process [9][10][11]. For more details on the molecular basis, photosensitizers in medicine, the reaction mechanism, and the various modifications in PDT can be found in the literature [12][13][14][15][16][17][18]. The photosensitizers most used in PDT are the drug families: Porphyrin, Chlorin and Dyes [19].…”

Section: Introductionmentioning

confidence: 99%

A new natural detector for irradiations with blue LED light source in photodynamic therapy measurements via UV–Vis spectroscopy

Oliveira

Nascimento

Caldas

2021

Photochem Photobiol Sci

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Photodynamic therapy has been recently studied, bringing innovations regarding the reduction of exposure time to light by the patient. This work aimed to investigate the feasibility of using Coutarea hexandra (Jacq.) K. Schum (CHS) as a detector in photodynamic therapy measurements. For this, an irradiator containing a blue LED bulb lamp was utilized. The CHS samples were irradiated with ten doses from 0.60 up to 6.0 kJ/cm 2 , and six concentrations were prepared (1, 2, 3, 4, 5, and 6 mg/ml) for the CHS detector samples. After irradiation, the detector samples were evaluated using UV-Vis spectrophotometry. The results showed the behavior of the CHS detector with doses and concentrations, its sensitivity, and its linearity was also evaluated both by Wavelength Method (WM) and the Kernel Principal Component Regression (KPCR) Statistical Method. The values obtained indicate that this method can be applied to the CHS sample detector. In conclusion, the CHS is a promising detector in the field of photodynamic therapy.

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Photodynamic therapy treatment of superficial fungal infections: A systematic review

Cited by 78 publications

References 52 publications

Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions

Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions

Electron Transfer-Supported Photodynamic Therapy

A new natural detector for irradiations with blue LED light source in photodynamic therapy measurements via UV–Vis spectroscopy

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