Photodynamic therapy using meso tetra hydroxy phenyl chlorin (mTHPC) in early prostate cancer

Moore, Caroline M.; Nathan, Timothy R.; Lees, WR; Mosse, Charles A.; Freeman, Alex; Emberton, Mark; Bown, Stephen G.

doi:10.1002/lsm.20275

Cited by 146 publications

(93 citation statements)

References 22 publications

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“…As of today several research groups have focused on treating prostate cancer using IPDT, where optical fibers are implanted into the prostate gland [1][2][3]. The fibers deliver therapeutic light, i.e., light that activates the photosensitizing drug, resulting in the generation of radicals.…”

mentioning

confidence: 99%

In vivo photosensitizer tomography inside the human prostate

2009

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mentioning

confidence: 99%

In vivo photosensitizer tomography inside the human prostate

2009

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“…mTHPC-mediated PDT was shown to be a safe and effective treatment for recurrent prostate cancer in a phase I trial [105,106]. Efficacy with low morbidity has also been demonstrated for pancreatic cancer [107], which, if confirmed, could have major health implications, because the 1-year survival rate is currently only 10%.…”

Section: Other Applicationsmentioning

confidence: 99%

Photodynamic Therapy in Oncology

Triesscheijn¹,

et al. 2006

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Photodynamic therapy (PDT) is increasingly being recognized as an attractive, alternative treatment modality for superficial cancer. Treatment consists of two relatively simple procedures: the administration of a photosensitive drug and illumination of the tumor to activate the drug. Efficacy is high for small superficial tumors and, except for temporary skin photosensitization, there are no long-term side effects if appropriate protocols are followed. Healing occurs with little or no scarring and the procedure can be repeated without cumulative toxicity. Considering the efficacy and lack of long-term toxicity of PDT, and the fact that the first treatment of cancer with PDT was done more than 100 years ago, one might expect that this treatment had already become an established therapy. However, PDT is currently offered in only a few selected centers, although it is slowly gaining acceptance as an alternative to conventional cancer therapies. Here, we show the developmental steps PDT underwent and summarize the current clinical applications. The data show that, when properly used, PDT is an effective alternative treatment option in oncology. The

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“…In terms of cancer control, PSA decreased in most patients but biopsy results revealed at least one positive core in each patient following treatment, but it is unclear as to where the tissue was obtained. 53 Several trials using the PDT compound WST11 are underway in an attempt to better define the role of focal PDT in PCa patients.…”

Section: Dovepressmentioning

confidence: 99%

The new era of minimally invasive interventions for prostate cancer: robot-assisted laparoscopic radical prostatectomy and focal therapy

Schatloff¹,

Louis²,

Lindner³

2011

OAS

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Prostate cancer remains a common but highly treatable disease. Innovations in prostate cancer treatment have allowed a transition toward minimally invasive approaches in an attempt to avoid treatment-related morbidities. In the middle of the treatment spectrum between radical open surgeries and active surveillance lies robot-assisted laparoscopic radical prostatectomy (RALP) and focal therapy (FT). This review sets out the most current information on RALP and FT (including laser ablation, cryotherapy, high-intensity focused ultrasound, photodynamic therapy, and irreversible electroporation).

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Photodynamic therapy using meso tetra hydroxy phenyl chlorin (mTHPC) in early prostate cancer

Cited by 146 publications

References 22 publications

In vivo photosensitizer tomography inside the human prostate

In vivo photosensitizer tomography inside the human prostate

Photodynamic Therapy in Oncology

The new era of minimally invasive interventions for prostate cancer: robot-assisted laparoscopic radical prostatectomy and focal therapy

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