Photodynamic Therapy Using Novel Zinc Phthalocyanine Derivatives and a Diode  Laser for Superficial Tumors in  Experimental Animals

Obata, Tohru; Mori, Shigeki; Suzuki, Yuka; Kashiwagi, Takuto; Tokunaga, Etsuko; Shibata, Norio; Tanaka, Motohiro

doi:10.4236/jct.2015.61008

Cited by 15 publications

(12 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Absorption, λ abs [nm], (A rel [a] ), {fwhm} [cm À 1 ] Fluorescence emission [b] Stokes shift Soret phthalocyanine, [31] which were evaluated by mouse B16 melanoma cells.…”

Section: Compoundmentioning

confidence: 99%

Synthesis of C3/C13‐Substituted Semi‐Synthetic Bacteriochlorophyll‐a Derivatives and Their Properties as Functional Dyes

et al. 2020

View full text Add to dashboard Cite

Natural bacteriochlorophyll-a was converted to chemically stable free-base derivatives with different substituents along the y-axis. Compared to the natural type compound methyl pyrobacteriopheophorbide-a possessing the C3-acetyl and C13keto-carbonyl groups, its deoxo-bacteriochlorin lacking the C3and C13-carbonyl groups showed a blue-shift of the Q y peak. On the other hand, introduction of the dicyanomethylene group(s) at the 3 1-and/or 13 1-position(s) caused an opposite effect due to its electron-withdrawing ability as well as the expansion of the π-conjugation system along the y-axis, and the Q y peak maxima were red-shifted to around 780 nm. These semi-synthetic bacteriochlorins in an aerated solvent could generate singlet oxygen upon illumination with far-red light, which was evaluated by mouse B16 melanoma cells to be applicable as photosensitizers. Besides this, it was demonstrated that they could be utilized as electron-donating materials combined with fullerene derivatives to fabricate bulk-heterojunction organic solar cells.

show abstract

“…Absorption, λ abs [nm], (A rel [a] ), {fwhm} [cm À 1 ] Fluorescence emission [b] Stokes shift Soret phthalocyanine, [31] which were evaluated by mouse B16 melanoma cells.…”

Section: Compoundmentioning

confidence: 99%

Synthesis of C3/C13‐Substituted Semi‐Synthetic Bacteriochlorophyll‐a Derivatives and Their Properties as Functional Dyes

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Pc also has promising use in chemical sensor as shown by Braik et al [35] where they used Co(II) phthalocyanine acrylate polymer for perchlorate anion detection [35]. In the field of medicine, derivatives of pc are now being used in photodynamic therapy of cancer as they show strong absorption in far red-light in the wavelength 600-800 nm [35,36]. Pc derivatives are a promising photosensitizer in fight of pathogenic microbes.…”

Section: Applications Of Phthalocyaninementioning

confidence: 99%

Antimicrobial Photodynamic Activity of Phthalocyanine Derivatives

Nyamu

Ombaka

Masika

et al. 2018

Advances in Chemistry

View full text Add to dashboard Cite

Microbial pathogens have increasingly shown multidrug resistance posing a serious threat to the public health. Advances in technology are opening novel avenues for discovery of compounds that will mitigate the ever-increasing drug-resistant microbes. Use of photodynamic photosensitizer is one of the promising alternative approaches since they offer low risk of bacteria resistance as they use generated reactive oxygen species to kill the microbes. Phthalocyanine (Pc) is one such photosensitizer which has already shown promising antimicrobial photodynamic therapeutic properties. Previous studies have shown effectiveness of the Pc against Gram-positive bacteria. However, its effectiveness toward Gram-negative bacteria is limited by the impermeability of the bacteria’s outer membrane which is made up of lipopolysaccharides layer. The effectiveness of this photosensitizer is determined by its photophysical and photochemical properties such as singlet/triplet lifetimes, singlet oxygen quantum yields, and fluorescence quantum yield. Therefore, this review focuses on the recent significance advances on designing Pc that have this improved property by either conjugating with nanoparticles, quantum dots, functional groups in peripheral position, considering effect of cationic charge, and its position on the macrocycle.

show abstract

“…After that TFEO-ZnPc/cyclodextrin conjugates 18 were reported under similar conditions ( Scheme 7 ) [ 100 ]. That study revealed that cyclodextrin-linked TFEO-Pcs have a non-aggregation property and sufficient water solubility, similar to the deoxyribonucleoside conjugates.…”

Section: Reviewmentioning

confidence: 99%

Synthesis and application of trifluoroethoxy-substituted phthalocyanines and subphthalocyanines

Mori

Shibata

2017

Beilstein J. Org. Chem.

Self Cite

View full text Add to dashboard Cite

Phthalocyanines and subphthalocyanines are attracting attention as functional dyes that are applicable to organic solar cells, photodynamic therapy, organic electronic devices, and other applications. However, phthalocyanines are generally difficult to handle due to their strong ability to aggregate, so this property must be controlled for further applications of phthalocyanines. On the other hand, trifluoroethoxy-substituted phthalocyanines are known to suppress aggregation due to repulsion of the trifluoroethoxy group. Furthermore, the electronic characteristics of phthalocyanines are significantly changed by the strong electronegativity of fluorine. Therefore, it is expected that trifluoroethoxy-substituted phthalocyanines can be applied to new industrial fields. This review summarizes the synthesis and application of trifluoroethoxy-substituted phthalocyanine and subphthalocyanine derivatives.

show abstract

Photodynamic Therapy Using Novel Zinc Phthalocyanine Derivatives and a Diode Laser for Superficial Tumors in Experimental Animals

Cited by 15 publications

References 24 publications

Synthesis of C3/C13‐Substituted Semi‐Synthetic Bacteriochlorophyll‐a Derivatives and Their Properties as Functional Dyes

Synthesis of C3/C13‐Substituted Semi‐Synthetic Bacteriochlorophyll‐a Derivatives and Their Properties as Functional Dyes

Antimicrobial Photodynamic Activity of Phthalocyanine Derivatives

Synthesis and application of trifluoroethoxy-substituted phthalocyanines and subphthalocyanines

Contact Info

Product

Resources

About