Photodynamic therapy: When van der Waals heterojunction meets tumor

Dai, Jiayong; Chen, Jiaxin; Song, Jibin; Ji, Yinwen; Qiu, Yuan; Hong, Zhongzhu; Song, Honghai; Yang, Li‐Tao; Zhu, Yutao; Li, Lei; Yang, Huanghao; Hu, Zhijun

doi:10.1016/j.cej.2021.129773

Cited by 11 publications

(12 citation statements)

References 49 publications

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“…The addition of two molten salts could accelerate the polymerization process and further adjust the structure and property of pristine CN . Chemical oxidation along with liquid exfoliation was then conducted to obtain HCN nanosheets . The size of the final products, varying from 100 to 200 nm, was confirmed by transmission electron microscopy (TEM, Figure A).…”

Section: Results and Discussionmentioning

confidence: 99%

“…Owing to π–π electronic transitions in the π-conjugated CN heterocycles, bare HCN showed poor absorption of visible light, let alone NIR light . Notably, HCN@CuMS exhibited much better light absorption property, mainly benefiting from the antenna effect and broad light absorption capacity of CuMS . Meanwhile, common electrochemical characterization techniques, including electrochemical impedance spectroscopy (EIS), transient photocurrent response, and Mott–Schottky plots were also applied to investigate charge transfer and separation efficiency of electron hole pairs.…”

Section: Results and Discussionmentioning

confidence: 99%

“…Recently, dozens of nanoagents based on various two-dimensional (2D) nanomaterials and their composites, like layered double hydroxides (LDHs), black phosphorus (BP) nanosheets, transition metal carbides (MXenes), transition metal dichalcogenides (TMDs), and carbon nitride (CN) have sprung up in catalytic tumor therapy. − Among them, CN-based hybrids have aroused great concern for their biocompatibility and optical and electrical characteristics. As a typical semiconductor, pristine CN owns a large bandgap about 2.7 eV, which brings about the difficulty of photo-induced electron–hole pair separation and thus leading to insufficient ROS generation. , During the past few years, several attempts including rational modulation of the original structure, bandgap engineering, dye sensitization, and heterojunction construction have been made to overcome this hurdle. − Meanwhile, our previous researches also have proved that constructing the semiconductor-metal (S-M) heterojunction between metallic molybdenum disulfide (1T-MoS 2 ) nanosheets and CN nanosheets or using copper doped conjugated polymers (CuPANI) to build heterostructure with CN could enhance near-infrared (NIR) light responsiveness and photocatalytic ROS generation at the same time. , The strategy to construct heterojunctions with other materials is undoubtedly advisable while retaining the property of a single component. Nonetheless, how to develop the nanoheterojunction with better catalytic performance through a relatively facile approach, and integrate other promising treatment modalities based on catalytic therapy, such as pyroptosis, ferroptosis, and cuproptosis, is definitely a great challenge. − …”

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confidence: 99%

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Copper-Loaded Nanoheterojunction Enables Superb Orthotopic Osteosarcoma Therapy via Oxidative Stress and Cell Cuproptosis

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Catalytic tumor therapy based on two-dimensional (2D) nanomaterials is a burgeoning and promising tumor therapeutic modality. However, the inefficient utilization and conversion of exogenous stimulation, single catalytic modality, and unsatisfactory therapeutic efficiency in the tumor microenvironment (TME) have seriously restricted their further application in tumor therapy. Herein, the heterogeneous carbon nitride-based nanoagent named T-HCN@CuMS was successfully developed, which dramatically improved the efficiency of the tumor therapeutic modality. Benefiting from the donor−acceptor (triazine-heptazine) structure within the heterogeneous carbon nitride nanosheets (HCN) and the construction of interplanar heterostructure with copper loaded metallic molybdenum bisulfide nanosheets (CuMS), T-HCN@CuMS presented a favorable photoinduced catalytic property to generate abundant reactive oxygen species (ROS) under near-infrared (NIR) light irradiation. Besides, the choice of CuMS simultaneously enabled this nanoagent to efficiently catalyze the Fenton-like reaction and trigger cell cuproptosis, a recently recognized regulated cell death mode characterized by imbalanced intracellular copper homeostasis and aggregation of lipoylated mitochondrial proteins. Moreover, upon surface modification with cRGD fk -PEG 2k -DSPE, T-HCN@CuMS was prepared and endowed with improved dispersibility and α v β 3 integrins targeting ability. In general, through the rational design, T-HCN@CuMS was facilely prepared and had achieved satisfactory antitumor and antimetastasis outcomes both in vitro and in a high-metastatic orthotopic osteosarcoma model. This strategy could offer an idea to treat malignant diseases based on 2D nanomaterials.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Copper-Loaded Nanoheterojunction Enables Superb Orthotopic Osteosarcoma Therapy via Oxidative Stress and Cell Cuproptosis

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Hu,

et al. 2023

ACS Nano

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“…Apart from noble metals, metallic transition metal dichalcogenides can be employed to transfer photoinduced electrons. Dai and co-workers integrated graphitic carbon nitride (CN) and metallic molybdenum disulfide (MS) into a CN@MS heterojunction system [80] in which MS acted as the antenna to respond to the incident light and induce the injection of photogenerated electrons into the CN for electron-hole separation (Figure 14J,K). To prove the successful construction of this heterostructure, DFT calculations were performed.…”

Section: S-m Heterojunctionmentioning

confidence: 99%

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confidence: 99%

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Exogenous stimulation catalytic therapy has received enormous attention as it holds great promise to address global medical issues. However, the therapeutic effect of catalytic therapy is seriously restricted by the fast charge recombination and the limited utilization of exogenous stimulation by catalysts. In the past few decades, many strategies have been developed to overcome the above serious drawbacks, among which heterojunctions are the most widely used and promising strategy. This review attempts to summarize the recent progress in the rational design and fabrication of heterojunction nanomedicine, such as semiconductor-semiconductor heterojunctions (including type I, type II, type III, P-N, and Z-scheme junctions) and semiconductor-metal heterojunctions (including Schottky, Ohmic, and localized surface plasmon resonance-mediated junctions). The catalytic mechanisms and properties of the above junction systems are also discussed in relation to biomedical applications, especially cancer treatment and sterilization. This review concludes with a summary of the challenges and some perspectives on future directions in this exciting and still evolving field of research.

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Sonocatalytic Optimization of Titanium‐Based Therapeutic Nanomedicine

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Recent considerable technological advances in ultrasound‐based treatment modality provides a magnificent prospect for scientific communities to conquer the related diseases, which is featured with remarkable tissue penetration, non‐invasive and non‐thermal characteristics. As one of the critical elements that influences treatment outcomes, titanium (Ti)‐based sonosensitizers with distinct physicochemical properties and exceptional sonodynamic efficiency have been applied extensively in the field of nanomedical applications. To date, a myriad of methodologies has been designed to manipulate the sonodynamic performance of titanium‐involved nanomedicine and further enhance the productivity of reactive oxygen species for disease treatments. In this comprehensive review, the sonocatalytic optimization of diversified Ti‐based nanoplatforms, including defect engineering, plasmon resonance modulation, heterojunction, modulating tumor microenvironment, as well as the development of synergistic therapeutic modalities is mainly focused. The state‐of‐the‐art Ti‐based nanoplatforms ranging from preparation process to the extensive medical applications are summarized and highlighted, with the goal of elaborating on future research prospects and providing a perspective on the bench‐to‐beside translation of these sonocatalytic optimization tactics. Furthermore, to spur further technological advancements in nanomedicine, the difficulties currently faced and the direction of sonocatalytic optimization of Ti‐based therapeutic nanomedicine are proposed and outlooked.

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Photodynamic therapy: When van der Waals heterojunction meets tumor

Cited by 11 publications

References 49 publications

Copper-Loaded Nanoheterojunction Enables Superb Orthotopic Osteosarcoma Therapy via Oxidative Stress and Cell Cuproptosis

Copper-Loaded Nanoheterojunction Enables Superb Orthotopic Osteosarcoma Therapy via Oxidative Stress and Cell Cuproptosis

Heterojunction Nanomedicine

Sonocatalytic Optimization of Titanium‐Based Therapeutic Nanomedicine

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