Photodynamic treatment of acute vascular occlusion by using an iron–nitrosyl complex

Choe, Jisu; Kim, Soo Jin; Kim, Junhyeong; Baik, Mu‐Hyun; Lee, Junyeop; Cho, Jaeheung

doi:10.1016/j.chempr.2023.02.013

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…Recently, synthetic DNICs have emerged as a type of novel and effective prodrug for controlled delivery of NO and NO-related biomedical applications. − In particular, thiolate-bridged dinuclear {Fe(NO) 2 } 9 -{Fe(NO) 2 } 9 DNIC [(NO) 2 Fe(μ-SCH 2 CH 2 OH) 2 Fe(NO) 2 ] displayed in vitro anti-inflammation activity against LPS-activated microglial BV-2 cells and in vivo therapeutic efficacy for the recovery of impaired cognitive ability of aging mice with metabolic syndrome . Alternatively, {Fe(NO) 2 } 9 -{Fe(NO) 2 } 9 DNIC 1 was explored for efficient nitroxylation of Fe III -porphyrin centers in Fe(TPP)Cl and met-myoglobin, while the in vitro and in vivo investigations are forthcoming.…”

Section: Conclusion and Commentsmentioning

confidence: 99%

“…In addition to providing the biomimetic insights into Fe-NO biology, recently, biomimetic dinitrosyl iron complexes (DNICs) were explored for controlled delivery of NO and activation of NO-related biomedical applications. − Despite the reported study of interactions between {Fe(NO) 2 } 10 DNICs [(NO) 2 Fe(L)] (L = TMEDA, PMDTA, and 2,9-dimethyl-1,10-phenanthroline) and O 2 , − transformation of DNICs under (simulated) inflammatory conditions (i.e., presence of O 2 – ) remains elusive. Consequently, the reactions of dinuclear {Fe(NO) 2 } 9 -{Fe(NO) 2 } 9 DNICs [(NO) 2 Fe(μ- Me Pyr) 2 Fe(NO) 2 ] ( 1 ) and [(NO) 2 Fe(μ-SEt) 2 Fe(NO) 2 ] ( 3 ), respectively, toward O 2 – are investigated in this study to understand the ligand control over the reactivity of DNICs.…”

Section: Introductionmentioning

confidence: 99%

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Ligand Control of Dinitrosyl Iron Complexes for Selective Superoxide-Mediated Nitric Oxide Monooxygenation and Superoxide–Dioxygen Interconversion

Liao,

Tseng,

Cheng

et al. 2023

J. Am. Chem. Soc.

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Through nitrosylation of [Fe–S] proteins, or the chelatable iron pool, a dinitrosyl iron unit (DNIU) [Fe(NO)2] embedded in the form of low-molecular-weight/protein-bound dinitrosyl iron complexes (DNICs) was discovered as a metallocofactor assembled under inflammatory conditions with elevated levels of nitric oxide (NO) and superoxide (O2 –). In an attempt to gain biomimetic insights into the unexplored transformations of the DNIU under inflammation, we investigated the reactivity toward O2 – by a series of DNICs [(NO)2Fe(μ-MePyr)2Fe(NO)2] (1) and [(NO)2Fe(μ-SEt)2Fe(NO)2] (3). During the superoxide-induced conversion of DNIC 1 into DNIC [(K-18-crown-6-ether)2(NO2)][Fe(μ-MePyr)4(μ-O)2(Fe(NO)2)4] (2-K-crown) and a [Fe3+(MePyr) x (NO2) y (O) z ] n adduct, stoichiometric NO monooxygenation yielding NO2 – occurs without the transient formation of peroxynitrite-derived •OH/•NO2 species. To study the isoelectronic reaction of O2(g) and one-electron-reduced DNIC 1, a DNIC featuring an electronically localized {Fe(NO)2}9-{Fe(NO)2}10 electronic structure, [K-18-crown-6-ether][(NO)2Fe(μ-MePyr)2Fe(NO)2] (1-red), was successfully synthesized and characterized. Oxygenation of DNIC 1-red leads to the similar assembly of DNIC 2-K-crown, of which the electronic structure is best described as paramagnetic with weak antiferromagnetic coupling among the four S = 1/2 {FeIII(NO – )2}9 units and S = 5/2 Fe3+ center. In contrast to DNICs 1 and 1-red, DNICs 3 and [K-18-crown-6-ether][(NO)2Fe(μ-SEt)2Fe(NO)2] (3-red) display a reversible equilibrium of “3 + O2 – ⇋ 3-red + O2(g)”, which is ascribed to the covalent [Fe(μ-SEt)2Fe] core and redox-active [Fe(NO)2] unit. Based on this study, the supporting/bridging ligands in dinuclear DNIC 1/3 (or 1-red/3-red) control the selective monooxygenation of NO and redox interconversion between O2 – and O2 during reaction with O2 – (or O2).

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Section: Conclusion and Commentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ligand Control of Dinitrosyl Iron Complexes for Selective Superoxide-Mediated Nitric Oxide Monooxygenation and Superoxide–Dioxygen Interconversion

Liao,

Tseng,

Cheng

et al. 2023

J. Am. Chem. Soc.

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“…The photoinduced isomerism that exchanges the Fe–NO configuration with the Fe–ON configuration has been largely studied theoretically by DFT calculations which have provided structural and orbital insights into the broader effect of linkage isomerism in transition-metal nitrosyls . To date, many nitric oxide-releasing precursor complexes have been prepared with chromium, manganese, and ruthenium, but recently, the use of iron-based complexes has been demonstrated . Iron-nitrosyl complexes typically have an absorption spectrum in the visible and ultraviolet (UV) regions, which, in the latter case, is damaging to biological systems.…”

Section: Introductionmentioning

confidence: 99%

“… 12 To date, many nitric oxide-releasing precursor complexes have been prepared with chromium, manganese, and ruthenium, 13 but recently, the use of iron-based complexes has been demonstrated. 14 Iron-nitrosyl complexes typically have an absorption spectrum in the visible and ultraviolet (UV) regions, which, in the latter case, is damaging to biological systems. Due to the penetration depth of light into tissues and cells being dependent on wavelength, the targeted release of NO from a precursor complex can only be accomplished using near-infrared (NIR) light.…”

Section: Introductionmentioning

confidence: 99%

Simulations of the Aqueous “Brown-Ring” Complex Reveal Fluctuations in Electronic Character

Coates,

Banerjee,

Odelius

2023

Inorg. Chem.

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Ab initio molecular dynamics (AIMD) simulations of the aqueous [Fe(H 2 O) 5 (NO)] 2+ "brown-ring" complex in different spin states, in combination with multiconfigurational quantum chemical calculations, show a structural dependence on the electronic character of the complex. Sampling in the quartet and sextet ground states show that the multiplicity is correlated with the Fe−N distance. This provides a motivation for a rigid Fe−N scan in the isolated "brown-ring" complex to investigate how the multiconfigurational wave function and the electron density change around the FeNO moiety. Our results show that subtle changes in the Fe−N distance produce a large response in the electronic configurations underlying the quartet wave function. However, while changes in spin density and potential energy are pronounced, variations in charge are negligible. These trends within the FeNO moiety are preserved in structural sampling of the AIMD simulations, despite distortions present in other degrees of freedom in the bulk solution.

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Photonic control of image-guided ferroptosis cancer nanomedicine

Ko,

Yoo,

Min

et al. 2024

Coordination Chemistry Reviews

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Photodynamic treatment of acute vascular occlusion by using an iron–nitrosyl complex

Cited by 7 publications

References 35 publications

Ligand Control of Dinitrosyl Iron Complexes for Selective Superoxide-Mediated Nitric Oxide Monooxygenation and Superoxide–Dioxygen Interconversion

Ligand Control of Dinitrosyl Iron Complexes for Selective Superoxide-Mediated Nitric Oxide Monooxygenation and Superoxide–Dioxygen Interconversion

Simulations of the Aqueous “Brown-Ring” Complex Reveal Fluctuations in Electronic Character

Photonic control of image-guided ferroptosis cancer nanomedicine

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