Photodynamic treatment of cutaneous leishmaniasis

Sohl, Sirius; Kauer, Friederike; Paasch, Uwe; Simon, Jan C.

doi:10.1111/j.1610-0387.2007.06177.x

Cited by 42 publications

(27 citation statements)

References 12 publications

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“…PDT of 75 J/cm 2 red light performed 12 weeks also showed good results 102. Leishmania tropica infection which proved to be resistant to various therapeutic regimes was effectively treated by PDT 103. It is also more effective than topical paromomycin and methylbenzethonium chloride used for cutaneous Leishmaniasis 104.…”

Section: Pdt Of Leishmaniasismentioning

confidence: 99%

Photodynamic therapy for infections: Clinical applications

et al. 2011

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Background and Objective Photodynamic therapy (PDT) was discovered over 100 years ago by its ability to kill various microorganisms when the appropriate dye and light were combined in the presence of oxygen. However it is only in relatively recent times that PDT has been studied as a treatment for various types of localized infections. This resurgence of interest has been partly motivated by the alarming increase in drug resistance amongst bacteria and other pathogens. This review will focus on the clinical applications of antimicrobial PDT. Study Design/Materials and Methods The published peer-reviewed literature was reviewed between 1960 and 2011. Results The basics of antimicrobial PDT are discussed. Clinical applications of antimicrobial PDT to localized viral infections caused by herpes and papilloma viruses, and nonviral dermatological infections such as acne and other yeast, fungal and bacterial skin infections are covered. PDT has been used to treat bacterial infections in brain abscesses and non-healing ulcers. PDT for dental infections including periodontitis and endodontics has been well studied. PDT has also been used for cutaneous Leishmaniasis. Clinical trials of PDT and blue light alone therapy for gastric Helicobacter pylori infection are also covered. Conclusion As yet clinical PDT for infections has been mainly in the field of dermatology using 5-aminolevulanic acid and in dentistry using phenothiazinium dyes. We expect more to see applications of PDT to more challenging infections using advanced antimicrobial photosensitizers targeted to microbial cells in the years to come.

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Section: Pdt Of Leishmaniasismentioning

confidence: 99%

Photodynamic therapy for infections: Clinical applications

et al. 2011

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“…Various case reports and series have documented successful treatment of cutaneous leishmaniasis using PDT. Studies have also shown PDT to be effective in the treatment of antibiotic-resistant cutaneous leishmaniasis, further strengthened by another study comparing the efficacy of PDT versus paromomycin or methylbenzethonium chloride 148–151. Individual cases demonstrating successful treatment using MAL-PDT include an 8-year-old Italian girl and an Austrian patient infected with Leishmania major 91,152.…”

Section: Pdt In Microbial Diseasesmentioning

confidence: 99%

Current evidence and applications of photodynamic therapy in dermatology

Wan¹,

Lin²

2014

CCID

117

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In photodynamic therapy (PDT) a photosensitizer – a molecule that is activated by light – is administered and exposed to a light source. This leads both to destruction of cells targeted by the particular type of photosensitizer, and immunomodulation. Given the ease with which photosensitizers and light can be delivered to the skin, it should come as no surprise that PDT is an increasingly utilized therapeutic in dermatology. PDT is used commonly to treat precancerous cells, sun-damaged skin, and acne. It has reportedly also been used to treat other conditions including inflammatory disorders and cutaneous infections. This review discusses the principles behind how PDT is used in dermatology, as well as evidence for current applications of PDT.

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“…PDT of 75 J/cm 2 red light performed 12 weeks also showed good results (135). Sohl, Kauer et al reported that excellent results were achieved with PDT on a patient with facial cutaneous Leishmania tropica infection which proved to be resistant to various therapeutic regimes (136). PDT was showed to be more effective than topical paromomycin and methylbenzethonium chloride in the therapy of cutaneous leishmaniasis (137).…”

Section: Pdt For Clinical Infectious Diseasementioning

confidence: 99%

Photodynamic therapy for localized infections—State of the art

Dai

Huang

Hamblin

2009

Photodiagnosis and Photodynamic Therapy

677

494

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Photodynamic therapy (PDT) was discovered over one hundred years ago by observing the killing of microorganisms when harmless dyes and visible light were combined in vitro. Since then it has primarily been developed as a treatment for cancer, ophthalmologic disorders and in dermatology. However in recent years interest in the antimicrobial effects of PDT has revived and it has been proposed as a therapy for a large variety of localized infections. This revival of interest has largely been driven by the inexorable increase in drug resistance amongst many classes of pathogen. Advantages of PDT include equal killing effectiveness regardless of antibiotic resistance, and a lack of induction of PDT resistance. Disadvantages include the cessation of the antimicrobial effect when the light is turned off, and less than perfect selectivity for microbial cells over host tissue. This review will cover the use of PDT to kill or inactivate pathogens in ex vivo tissues and in biological materials such as blood. PDT has been successfully used to kill pathogens and even to save life in several animal models of localized infections such as surface wounds, burns, oral sites, abscesses and the middle ear. A large number of clinical studies of PDT for viral papillomatosis lesions and for acne refer to its anti-microbial effect, but it is unclear how important this microbial killing is to the overall therapeutic outcome. PDT for periodontitis is a rapidly growing clinical application and other dental applications are under investigation. PDT is being clinically studied for other dermatological infections such as leishmaniasis and mycobacteria. Antimicrobial PDT will become more important in the future as antibiotic resistance is only expected to continue to increase.

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Photodynamic treatment of cutaneous leishmaniasis

Cited by 42 publications

References 12 publications

Photodynamic therapy for infections: Clinical applications

Photodynamic therapy for infections: Clinical applications

Current evidence and applications of photodynamic therapy in dermatology

Photodynamic therapy for localized infections—State of the art

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