1997
DOI: 10.1111/j.1751-1097.1997.tb03181.x
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Photodynamic Treatment of Red Blood Cell Concentrates For Virus Inactivation Enhances Red Blood Cell Aggregation: Protection with Antioxidants

Abstract: Photodynamic treatment (PDT) using phthalocyanines and red light appears to be a promising procedure for decontamination of red blood cell (RBC) concentrates for transfusion. A possible complication of this treatment may be induced aggregation of RBC. The production of RBC aggregates was measured with a novel computerized cell flow properties analyzer (CFA). The PDT of RBC concentrates with sulfonated aluminum phthalocyanine (AIPcS4) and the silicon phthalocyanine Pc 4 under virucidal conditions markedly enhan… Show more

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Cited by 27 publications
(14 citation statements)
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“…These findings are consistent with the lipid envelope being the main site of action for photodynamic inactivation [73]. Pc 4 appears to be an excellent photosensitizer for purging blood supplies of enveloped viruses [74,75].…”
Section: Photodynamic Inactivation Of Enveloped Virusessupporting
confidence: 76%
“…These findings are consistent with the lipid envelope being the main site of action for photodynamic inactivation [73]. Pc 4 appears to be an excellent photosensitizer for purging blood supplies of enveloped viruses [74,75].…”
Section: Photodynamic Inactivation Of Enveloped Virusessupporting
confidence: 76%
“…Under conditions leading to virus sterilization the blood borne parasites Trypanosoma cruzi (Chagas disease) and Plasmodium falciparum (malaria) could be eliminated to undetectable levels (> 4 log10 kill). RBC damage during treatment could be avoided by increasing the light fluence rate to 80 mW/cm 2 , and by including the free radical scavenger glutathione and the vitamin E derivative Trolox during light exposure procedures (39). …”
Section: Antimicrobial Pdt Ex Vivo or In Biological Materialsmentioning
confidence: 99%
“…Ambos podem conferir proteção às RBC sem comprometer a inativação viral. Ben-Hur et al sugerem o uso da mistura de antioxidantes vitamina E, manitol e glutationa para evitar o problema de agregação das células 30 .…”
Section: Desinfecção Do Sangueunclassified