Photodynamische Ablation und Argon-Plasmacoagulation von prämalignen und frühmalignen Läsionen des Oesophagus Eine Alternative zur Chirurgie?

Orth, Klaus; Stănescu, Anca Daniela; Rück, Angelika; Russ, Detlef; Beger, Hans G.

doi:10.1007/s001040050667

Cited by 19 publications

(14 citation statements)

References 23 publications

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“…Azul de metileno tem sido usado clinicamente no tratamento de câncer de bexiga e, recentemente, contra tumores de esôfago inoperáveis, virulências da pele, psoríase e adenocarcinomas 15 .…”

Section: Fenotiazínicosunclassified

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Inativação fotodinâmica de microrganismos

Perussi¹

2007

Quím. Nova

113

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Section: Fenotiazínicosunclassified

“…Foi relatado que a metilação cromofórica do AM diminui a tendência à redução 13 . Foi descrito um estudo com AM em tumores colorretais experimentais de camundongo em que foi concluído que existe uma dose limiar para o AM que previne o dano oxidativo no tecido 15 .…”

Section: Introductionunclassified

Inativação fotodinâmica de microrganismos

Perussi¹

2007

Quím. Nova

113

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“…Furthermore, hepatic synthesis of PP IX from 5-ALA is quite effective with subsequent transport of PP IX in the blood to peripheral sites. However, PP IX and other intermediates are rapidly eliminated from the organism and hence the risk of skin photosensitivity is limited to a maximum of 48 h [20]. 5-ALA can be applied locally and orally, providing an acceptable administration route for patients.…”

Section: In Vivo Staining Of Tissuementioning

confidence: 99%

Fluorescence detection of small gastrointestinal tumours: principles, technique, first clinical experience

Orth

Russ

Steiner

et al. 2000

Langenbeck's Archives of Surgery

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Photodynamic therapy (PDT) is a form of cancer treatment based on the selective accumulation of a photosensitizer in neoplastic tissue. The fluorescent properties of a photosensitizer permit diagnostic localization of primary tumours and/or metastasis. Occult lesions are hard to detect and can easily be missed during routine laparoscopy. Fluorescence observation offers additional optical information and the ability to detect these occult tumours. Clinically, we used 5-aminolevulinic acid for peritoneal staining and tumour demarcation via tumour-specific fluorescence induced by protoporphyrin IX. For laparoscopic observations, a "D-Light" system was used; the conventional white light source was equipped with an optical blocking filter that transmits at the excitation wavelength (380-450 nm) and blocks all other parts of the spectrum. With the aid of a suitable observation filter, the relevant fluorescence was detectable. With the help of this fluorescence we increased the capacity to detect occult tumours, that were missed with white-light observation (9/26). In the gastrointestinal tract, we used a krypton laser at 405 nm for PP IX fluorescence induction. Although there were high sensitivity rates for neoplasms (81% peritoneal carcinomas, 60% gastric cancer), no exact histopathological statement could be achieved at because of false-positive fluorescence, mainly caused by inflammation (6/32). Current clinical goals and the future perspectives of photodynamic diagnostic are discussed.

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“…Methylene blue is an active photosensitizer used in photodynamic therapy of malignant tumors [13]. As shown above, caffeine can "bind" aromatic dyes by means of heteroassociation [7,8,10].…”

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confidence: 99%

Aggregation of 1,3,7-trimethylxanthine with methylene blue in aqueous solution

2006

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We have studied self-association of aromatic molecules of the thiazine dye methylene blue in aqueous solution, using a dimer model. We have determined the dimerization equilibrium constant for the dye molecules K D = 3900 ± 800 M -1 at T = 293 K. We have decomposed the experimental spectrum into dimer and monomer components. Using the ratio of the molar absorption coefficients for two absorption bands of the dimer spectrum, we obtained the "average" value of the angle between the electronic transition moments of the molecules in the dimers, α = 48 o .We have studied heteroassociation of methylene blue (MB) and 1,3,7-trimethylxanthine (caffeine) molecules in aqueous solution. We have calculated the heteroassociation constant as 200 ± 34 M -1 . We conclude that heteroassociation of methylene blue and caffeine molecules leads to a lower effective dye concentration in solution, which hypothetically may affect its biological activity.We have determined the values of the Gibbs free energy, the enthalpy, and the entropy for dimerization of methylene blue molecules: ∆G 293 = -(20 ± 3) kJ/mol, ∆H = -(25 ± 9) kJ/mol, ∆S 293 = -(17 ± 6) J/mol⋅K; and for methylene blue-caffeine heteroassociation: ∆G 293 = -(13 ± 3) kJ/mol, ∆H = -(14 ± 10) kJ/mol, ∆S 293 = -(2.4 ± 0.2) J/mol⋅K, respectively. We have shown that the methylene blue aggregates and the heteroassociates with caffeine are predominantly stabilized by dispersion interactions between the chromophore molecules in the associates.

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Photodynamische Ablation und Argon-Plasmacoagulation von prämalignen und frühmalignen Läsionen des Oesophagus Eine Alternative zur Chirurgie?

Cited by 19 publications

References 23 publications

Inativação fotodinâmica de microrganismos

Inativação fotodinâmica de microrganismos

Fluorescence detection of small gastrointestinal tumours: principles, technique, first clinical experience

Aggregation of 1,3,7-trimethylxanthine with methylene blue in aqueous solution

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