Photoelectric Protein Nanofibrils of α‐Synuclein with Embedded Iron and Phthalocyanine Tetrasulfonate

Choi, Yeon Sun; Kim, Je-Hoon; Bhak, Ghibom; Lee, Daekyun; Paik, Seung R.

doi:10.1002/ange.201006859

Cited by 5 publications

(2 citation statements)

References 32 publications

(19 reference statements)

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“…A peptide fragment of transerythritin (TTR 105-115) spontaneously forms highly aligned uniform fibrils in which fluors can be incorporated with little disruption in fibril structure to provide an amyloid fibril with the ability to capture photons and harvest light [269]. Aβ (16)(17)(18)(19)(20)(21)(22)-α-synuclein hybridised amyloid fibrils also exhibit light-harvesting and electron-transfer properties [270].…”

Section: Application Of Amyloid Fibrils In Nanobiology and Organic Mi...mentioning

confidence: 99%

Amyloid, a Jekyll and Hyde Molecule Inducing Neuronal Decline and Cognitive Dysfunction is Also a Unique Molecular Template used in Nano-electronics, Light Capture Photovoltaics, and Biosensors in Neuromorphic Computing.

Melrose,

Smith

2024

Preprint

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Amyloid self-assembled from amyloid peptides βΑ40 or βΑ42 is notorious for its neurotoxic effects in plaque and neurofibrillary tangle formations leading to neuron dysfunction and diseases of cognitive decline (e.g. Alzheimer’s, Parkinson’s and Huntington's disease). This contrasts with so-called functional amyloids which are non-toxic ordered template structures amenable to applications in tissue engineering. Amyloid fibrils of variable morphology including long and hollow fibres and flattened tube and spiral ribbon-like structures have been used in engineering applications in nano-biology. Protein assemblies based on amyloid core structures display diverse biological functionalities could be applied in futuristic self-assembling biomaterials in nano-electronics. These possibilities have revolutionized the development of next generation computers and biosensors, ultracapacitors, memristors, actuators, molecular switches and could also be used to develop artificial synapses. Amyloid fibril assemblies have also been used in photoelectric and photon capture light harvesting technologies and been applied in innovative nano-photoelectronics and photovoltaics. Hybrid Aβ(16–22)-α-synuclein amyloid fibrils also exhibit light-harvesting and electron-transfer properties. Engineered amyloid assemblies are thus facilitating innovative futuristic advances in nano-technology. Furthermore, with a better understanding of amyloid fibril assembly processes it may be possible to develop therapeutic methods that prevent the toxic build up of this polymer in brain tissues that leads to diseases of cognitive decline. With the ever-expanding prevalence of these diseases in the ageing general global population, there certainly is a clear and present need to find a remedy for these debilitating conditions.

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Section: Application Of Amyloid Fibrils In Nanobiology and Organic Mi...mentioning

confidence: 99%

Amyloid, a Jekyll and Hyde Molecule Inducing Neuronal Decline and Cognitive Dysfunction is Also a Unique Molecular Template used in Nano-electronics, Light Capture Photovoltaics, and Biosensors in Neuromorphic Computing.

Melrose,

Smith

2024

Preprint

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“…One of the most recent and striking examples of the usefulness of a potentially dangerous, fibril-forming protein was described in [ 86 , 87 ]. The protein is α-synuclein which participates in the Lewy body formation in Parkinson’s disease.…”

Section: Amyloid Can Be Beneficial For Cells and Also Convenient For mentioning

confidence: 99%

Ubiquitous Amyloids

Puławski

Ghoshdastider

Andrisano

et al. 2012

Appl Biochem Biotechnol

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The common view of amyloids and prion proteins is that they are associated with many currently incurable diseases and present a great danger to an organism. This danger comes from the fact that not only prion proteins, but also the infectious form(s) of amyloids, as it has been shown recently, are able to transmit the disease. On the other hand, organisms take advantage of the strength and durability of specific forms of amyloids. Such forms do not spread any disease. Also, in nanotechnology there is a constantly growing need to employ amyloid fibrils in many industrial applications. With increasing knowledge about amyloids and prion proteins we are aware that the amyloidal state is inherent to any protein, making the problem of amyloid formation a central one in aging-related diseases. However, the “good” amyloids can be beneficial and even necessary for our health. Furthermore, because of their mechanical properties, the amyloids are of great interest to engineers.

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Compartmentalization within Nanofibers of Double‐Decker Phthalocyanine Induces High‐Performance Sensing in both Aqueous Solution and the Gas Phase

Jiang

Wang

Lü

et al. 2019

Chemistry A European J

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The functionalization of natural 1D architectures is dependent on hierarchically inner nanostructures. However,t he artificial supramolecular nanofiberso rn anotubes were rarely developed with complex inner structures. Inspired by ab iomimetic strategy,s ingle-molecule-diameter nanofibers of double-decker phthalocyanine (EuPc2) with compartmentalized internal space and fantastic electrochemical features were developed upon air/water interfacial assembly with poly-l-lysine. EuPc2/poly-l-lysine nanofibers can be electrochemical sensors both in water and the gas phase and have the best analytical performances for nitrite among all the porphyrins or phthalocyanines monomers and assemblies. Imbeddingnitrite in compartments not only promotes the sensingb ut also changes the supramolecular chirality of nanofibers, and the morphological-dependents ensing properties of EuPc2 assemblies in water are different from that in the gas phase. These resultss uggest the unprecedented properties for diverse applications of artificial 1D architectures containing complex inner nanostructures.Supporting information and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

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Photoelectric Protein Nanofibrils of α‐Synuclein with Embedded Iron and Phthalocyanine Tetrasulfonate

Cited by 5 publications

References 32 publications

Amyloid, a Jekyll and Hyde Molecule Inducing Neuronal Decline and Cognitive Dysfunction is Also a Unique Molecular Template used in Nano-electronics, Light Capture Photovoltaics, and Biosensors in Neuromorphic Computing.

Amyloid, a Jekyll and Hyde Molecule Inducing Neuronal Decline and Cognitive Dysfunction is Also a Unique Molecular Template used in Nano-electronics, Light Capture Photovoltaics, and Biosensors in Neuromorphic Computing.

Ubiquitous Amyloids

Compartmentalization within Nanofibers of Double‐Decker Phthalocyanine Induces High‐Performance Sensing in both Aqueous Solution and the Gas Phase

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