The selective catalytic reduction technology that uses CO as a reductant (CO-SCR) has great potential in addressing nitrogen oxides (NO x ) pollution in industry. Herein, we reported the in situ growth of highly efficient CuMnO 2 nanosheet catalysts on low-cost stainless steel mesh (SSM) by a hydrothermal method, which exhibited excellent CO-SCR performance. It has been demonstrated that the prepared CuMnO 2 nanosheet catalysts with high crystallinity and an exposed (001) plane could realize 100% NO conversion and N 2 selectivity at 310 °C, which is comparable to other reported Cu− Mn−O catalysts. Moreover, the reaction mechanism driven by the surface synergetic oxygen vacancy of Cu−□−Mn is also proposed for enhancement of the CO-SCR performance. The good mechanical strength, easy shape processability, and high temperature stability of the inexpensive SSM support, together with the good catalytic performance of the active CuMnO 2 component, could make the CuMnO 2 /SSM monolithic catalyst more favorable for large-scale industry application in de-NO x .