Photoimmunomodulation and melatonin

Haldar, Chandana; Ahmad, Raise

doi:10.1016/j.jphotobiol.2009.11.014

Cited by 56 publications

(54 citation statements)

References 139 publications

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“…33 Melatonin also has immunomodulatory and antiinflammatory effects. 34,35 We found that nocturnal melatonin levels were significantly higher in the patients with AD compared with the controls. It is also our novel finding that in patients with AD, a higher nocturnal melatonin level was associated with better sleep efficiency, less sleep fragmentation, and milder disease severity.…”

Section: Figurementioning

confidence: 76%

Atopic Dermatitis, Melatonin, and Sleep Disturbance

et al. 2014

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WHAT'S KNOWN ON THIS SUBJECT: Sleep disturbance affects 47% to 60% of children with atopic dermatitis and is a leading cause of impaired quality of life for the patients and their family. WHAT THIS STUDY ADDS:Sleep disturbance in children with atopic dermatitis can be predicted by a Scoring Atopic Dermatitis index of $48.7, and lower nocturnal melatonin secretion might play a role in the pathophysiology. abstract BACKGROUND AND OBJECTIVES: Sleep disturbance is common in patients with atopic dermatitis (AD). However, studies have largely been questionnaire-based, and the pathophysiology remains unclear. The aims of this study were to determine objective characteristics of sleep disturbance in children with AD and explore contributing factors and clinical predictors.METHODS: Sleep parameters were measured by actigraphy and polysomnography in 72 patients with AD and 32 controls ages 1 to 18 years. Urinary 6-sulfatoxymelatonin levels, serum cytokines, and total and allergen-specific immunoglobulin E (IgE) levels were also measured. RESULTS:The patients with AD had significantly reduced sleep efficiency, longer sleep onset latency, more sleep fragmentation, and less nonrapid eye movement sleep. Results from actigraphy correlated well with those from polysomnography. The AD disease severity was associated with sleep disturbance (r = 0.5520.7), and a Scoring Atopic Dermatitis index of $48.7 predicted poor sleep efficiency with a sensitivity of 83.3% and a specificity of 75% (area under the curve = 0.81, P = .001). Lower nocturnal melatonin secretion was significantly associated with sleep disturbance in the patients with AD. Other correlates of sleep disturbance included pruritus, scratching movements, higher total serum IgE levels, and allergic sensitization to dust mite and staphylococcal enterotoxins. CONCLUSIONS:Poor sleep efficiency is common in children with AD and can be predicted by the Scoring Atopic Dermatitis index. Melatonin and IgE might play a role in the sleep disturbance. Further studies are required to explore the mechanisms and clinical implications, and actigraphy could serve as a useful evaluating tool. Atopic dermatitis (AD) is a common chronically relapsing pruritic inflammatory skin disease. 1 Disturbed sleep is frequently reported by the patients and their family and is a major factor leading to an impaired quality of life. [2][3][4] Sleep disturbance can have many negative consequences, including impaired neurocognitive function, higher rates of behavioral problems, and changes in mood. 5,6 Therefore, the recognition and proper management of sleep disturbance should be an important issue in AD.The sleep disturbance in AD might be due to the pruritus and scratching movements during sleep, 7-10 but it is likely that other factors are involved. 11 Melatonin is a hormone secreted by the pineal gland that is essential for regulating the circadian rhythm. 12 Dysfunction in the diurnal secretion of melatonin in patients with AD has been reported, 13 but its association with their sleep disturbance has...

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Section: Figurementioning

confidence: 76%

Atopic Dermatitis, Melatonin, and Sleep Disturbance

et al. 2014

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“…Enhanced immune functions are generally observed in short days (Haldar and Ahmad, 2010). All laboratory studies of photoperiodic changes in immune parameters of mammals demonstrated enhanced immune function in short winter-like photoperiod, for example in mice significantly increased lymphocyte, neutrophil and white blood cell counts occur in short photoperiods (Blom et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…It is well established that melatonin takes part in immune response stimulation or regulation of immunodeficiencies secondary to acute stress and viral diseases (Esquifino et al, 2004). Melatonin was also identified as stimulator of the inflammation by activating monocytes and enhancing production of IL-1, IL-6 and TNFα (Haldar and Ahmad, 2010). It is generally accepted that immune function is enhanced in LN period (Haldar and Ahmad, 2010;Weil et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…This local action of the inflammatory mediators in the PT could have a profound effect on the secretory activity of the whole pituitary gland. It is worth mentioning that photoperiod influences immune system affecting the synthesis of proinflammatory cytokines (Haldar and Ahmad, 2010). It was described that there is diurnal fluctuation in both proand anti-inflammatory cytokines synthesis (Lange et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Photoperiod-dependent effect of inflammation on nocturnal gene expression of proinflammatory cytokines and their receptors in <i>pars tuberalis</i> of ewe

2016

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“…Mammals perceive visible light (400-700 nm), and experimental animal evidence suggests that each dimension of light can modify animal biology (10)(11)(12)(13)(14). In rodents, acute bright light exposure induced the release of corticosterone (15,16).…”

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confidence: 99%

Blue light reduces organ injury from ischemia and reperfusion

Yuan

Collage

Huang

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Evidence suggests that light and circadian rhythms profoundly influence the physiologic capacity with which an organism responds to stress. However, the ramifications of light spectrum on the course of critical illness remain to be determined. Here, we show that acute exposure to bright blue spectrum light reduces organ injury by comparison with bright red spectrum or ambient white fluorescent light in two murine models of sterile insult: warm liver ischemia/reperfusion (I/R) and unilateral renal I/R. Exposure to bright blue light before I/R reduced hepatocellular injury and necrosis and reduced acute kidney injury and necrosis. In both models, blue light reduced neutrophil influx, as evidenced by reduced myeloperoxidase (MPO) within each organ, and reduced the release of high-mobility group box 1 (HMGB1), a neutrophil chemotactant and key mediator in the pathogenesis of I/R injury. The protective mechanism appeared to involve an optic pathway and was mediated, in part, by a sympathetic (β3 adrenergic) pathway that functioned independent of significant alterations in melatonin or corticosterone concentrations to regulate neutrophil recruitment. These data suggest that modifying the spectrum of light may offer therapeutic utility in sterile forms of cellular injury.

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Photoimmunomodulation and melatonin

Cited by 56 publications

References 139 publications

Atopic Dermatitis, Melatonin, and Sleep Disturbance

Atopic Dermatitis, Melatonin, and Sleep Disturbance

Photoperiod-dependent effect of inflammation on nocturnal gene expression of proinflammatory cytokines and their receptors in <i>pars tuberalis</i> of ewe

Blue light reduces organ injury from ischemia and reperfusion

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