Photoinduced Alkylation of Diazines with N-(Acyloxy)phthalimides in the Presence of Triethylamine

Abstract

A photochemical protocol for the alkylation of diazines (pyrimidines, pyrazines and pyridazines) with N-(acyloxy)phthalimides has been developed. The process is facilitated in the presence of triethylamine (Et3N) under irradiation with 427-390 nm light, enabling rapid cross-coupling reactions to construct a wide range of alkylated diazines.