Photoinduced Nitric Oxide and Singlet Oxygen Release from ZnPC Liposome Vehicle Associated with the Nitrosyl Ruthenium Complex: Synergistic Effects in Photodynamic Therapy Application

Maranho, Daniela Silva; Lima, Renata Galvão de; Primo, Fernando Lucas; Silva, Roberto Santana da; Tedesco, Antônio Cláudio

doi:10.1111/j.1751-1097.2008.00481.x

Cited by 49 publications

(32 citation statements)

References 47 publications

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“…To overcome this problem, ZnPc derivatives, such as tetrasulfonated ZnPc (ZnPcS 4 ), 9 [1,2,3,4-tetrakis(a/b-Dgalactopyranos-6-yl)-phthalocyaninato]zinc, 10 tetra-and octatriethyleneoxysulfonyl substituted ZnPc, 11 have been designed to increase the water solubility. Various delivery vehicles including liposome, 12 emulsion 13 and nanoparticles 14 have also been developed to transport water-insoluble photosensitizers to targets. However, these approaches require multiple and complex chemical functionalization steps, during which the photoactivity could be reduced by destroying the original electronic conjugation system of the photosensitizer.…”

Section: Introductionmentioning

confidence: 99%

Significant increase in the water dispersibility of zinc phthalocyanine nanowires and applications in cancer phototherapy

et al. 2012

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The phototherapy is one of the widely accepted noninvasive clinical methodologies to eradicate cancer cells owing to its minimal side effects and high selectivity to the light of specific wavelength. As represented by photodynamic (PD) and photothermal (PT) therapy, the phototherapy requires light and photosensitizer to generate reactive oxygen species and heat, respectively. Zinc phthalocyanine (ZnPc) is one of the promising photosensitizers as it has a strong absorption cross-section in the spectral range of 650-900 nm that guarantees maximum tissue penetration. One critical issue in using Pc molecule, including ZnPc as a biocompatible sensitizer is the poor water solubility. To increase water solubility, various chemical modifications inducing hydrophilicity have been widely attempted to introduce various functional groups in the ZnPc backbone. We report that ZnPc nanowires (NWs) directly grown from ZnPc powder by vaporization-condensation-recrystallization process show surprisingly increased water dispersibility without any functionalization. The ZnPc NW solution exhibits highly efficient dual PD and PT effects upon the irradiation of near infrared (808 nm) laser. The dual phototherapeutic effect of ZnPc NW is proven to enhance cytotoxic efficiency according to both in vitro and in vivo experimental results. NPG Asia Materials (2012) 4, e12; doi:10.1038/am.2012.22; published online 13 April 2012Keywords: nanowire; photosensitizer; phototherapy; Zinc phthalocyanine INTRODUCTION Phototherapy, represented by photodynamic therapy (PDT) and photothermal therapy (PTT), is an advanced modality for the treatment of malignant tumors as it is widely used for clinical cancer treatments. PDT selectively destroys neoplastic lesions using cytotoxic reactive oxygen species (ROS) generated by light activation of the photosensitizer. 1,2 One of the crucial factors determining the PDT efficacy is the photochemical and photophysical properties of the photosensitizer. 3,4 Currently, four main classes of photosensitizer, such as porphyrin derivatives, chlorins, porphycenes, and phthalocyanines (Pcs), have been approved by the U.S. Food and Drug Administration (FDA) for clinical applications against cancer. 5,6 Among these, metallo-phthalocyanine has attracted considerable interest, having a photodynamic (PD) property that can be readily tuned by the type of central metal ion and the functional groups introduced as a Pc ring substituent. Zinc phthalocyanine (ZnPc) is known to exhibit a high PD effect as it possesses a diamagnetic Zn(II) central metal ion whose d shell is fully occupied, by which the yield of triplet excited state with long lifetime essential for the generation of ROS becomes high. 7 Moreover, ZnPc has

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Section: Introductionmentioning

confidence: 99%

Significant increase in the water dispersibility of zinc phthalocyanine nanowires and applications in cancer phototherapy

et al. 2012

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“…For studies of endothelium-denuded vessels, the rings were discarded if there was any degree of relaxation. [23] with zinc amalgam, as previously described for similar nitrosyl ruthenium complexes [10,16,[23][24][25][26][27][28]. The complex was characterized by UV-Visible (UV-Vis) spectroscopy, and then compared to the published results [23].…”

Section: Animals Vessel Preparation and Isometric Tension Measurementsmentioning

confidence: 99%

Endothelium negatively modulates the vascular relaxation induced by nitric oxide donor, due to uncoupling NO synthase

Bonaventura

Lunardi

Rodrigues

et al. 2009

Journal of Inorganic Biochemistry

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“…The choice of the source of light must be based on the absorption by the photosensitizer drug, the purpose of the action (treatment of a small cancerous lesion or wound healing stimulation), characteristics of the lesion or wound (local, size, accessibility, and characteristics of the tissue) costs and size [7]. A wide number of photosensitizers in different drug delivery systems (DDSs) have been tested for PDT [25][26][27][28][29]. Among them, phthalocyanines (Pc) have been under investigation as promising second-generation photosensitizers, not only for PDT, but also for other applications.…”

Section: Interaction Of Light In the Skinmentioning

confidence: 99%

Low Level Energy Photodynamic Therapy for Skin Processes and Regeneration

Tedesco¹,

Jesus²

2017

Photomedicine - Advances in Clinical Practice

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Skin is the largest human organ and displays multiple functions involving structure and protection against external agents that may affect the body. Solar radiation accelerates the normal aging process and may even cause great damage leading to many different cutaneous diseases and skin cancer. Moreover, a wound in the skin may be an open channel for the access of pathogens usually exposing blood vessels for infections and causing serious complications. For many reasons, regulatory skin processes are of great deal in different approaches: basic antiaging, wound healing, and skin cancer. In a good way, photoprocesses with specific wavelength at low energy levels associated with photoactive compounds are known to cause the opposite effect, promoting the healing of cutaneous diseases and leading to well-defined outcomes in rejuvenation and antiaging. This chapter will discuss the most relevant topics in photo skin regeneration using low energy levels associated with photodynamic therapy (PDT), which emerged as a combination to potentialize molecules with the already known effects of PDT and low level laser therapy (LLLT) in the treatment of skin pathologies, known as a photobiomodulation process.

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Photoinduced Nitric Oxide and Singlet Oxygen Release from ZnPC Liposome Vehicle Associated with the Nitrosyl Ruthenium Complex: Synergistic Effects in Photodynamic Therapy Application

Cited by 49 publications

References 47 publications

Significant increase in the water dispersibility of zinc phthalocyanine nanowires and applications in cancer phototherapy

Significant increase in the water dispersibility of zinc phthalocyanine nanowires and applications in cancer phototherapy

Endothelium negatively modulates the vascular relaxation induced by nitric oxide donor, due to uncoupling NO synthase

Low Level Energy Photodynamic Therapy for Skin Processes and Regeneration

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