Photoinduced regioselective difluorination of secondary inert C(sp³)–H bonds in sulfonamides via 1,5-hydrogen-atom transfer

Abstract

Difluorinated compounds are important structural motifs in organic synthesis and medicinal chemistry because fluoride can modulate the properties of various molecules. In this paper, we present an efficient and convenient...

Regioselective synthesis of isoquinolinonediones through remote unactivated C(sp3)–H bonds

“…Our group recently reported a photo-catalyzed, selective remote secondary C(sp 3 )–H fluorination of a wide range of aliphatic sulfonamides. 17 Use of hypervalent iodine agents also provided a strategy to generate HCRs. 18 Considering that alcohols and amides are widely distributed in nature and are readily accessible, 19,20 we wondered whether site-selective cascade addition/cyclization on the carbon chains of free alcohols and amides via HCR-directed distal C(sp 3 )–H activation could achieve the desired molecular complexity.…”