Photoinduced toxicity of retene to Daphnia magna under enhanced UV-B radiation

Huovinen, Pirjo; Soimasuo, Markus; Oikari, Aimo

doi:10.1016/s0045-6535(01)00014-5

Cited by 47 publications

(24 citation statements)

References 32 publications

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“…The UV radiation reaching the earth's surface is mainly composed of UV-A and a small quantity of UV-B whereas UV-C is almost completely absorbed by the stratospheric ozone. Moreover, UV has shown to modify the toxicity of many chemical stressors such as metals [65], polycyclic aromatic hydrocarbons [66,67], and pesticides [68,69] with-in the majority of studies-increasing toxicity of contaminants, which may result in synergistic (i.e. Moreover, UV has shown to modify the toxicity of many chemical stressors such as metals [65], polycyclic aromatic hydrocarbons [66,67], and pesticides [68,69] with-in the majority of studies-increasing toxicity of contaminants, which may result in synergistic (i.e.…”

Section: Uv Radiation Effects On Zebrafish Embryo Survival and Develomentioning

confidence: 99%

Zebrafish embryo tolerance to environmental stress factors—Concentration–dose response analysis of oxygen limitation, pH, and UV‐light irradiation

Andrade

Henriques

Almeida

et al. 2016

Enviro Toxic and Chemistry

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During the last century the increase in the mean global temperatures has been shown to impact on freshwater physicochemical parameters such as pH, dissolved oxygen, or ultraviolet (UV) light abundance. Changes in these parameters could modify the toxicity of environmental pollutants. Therefore, in the present study, the authors studied the tolerance (survival and sublethal endpoints) of zebrafish (Danio rerio) embryos to variations in pH (3-12), dissolved oxygen (3.9-237 μmol/L) and UV intensity (55-467 mW/m ) using selected endpoints. Sublethal endpoint assessment included the quantification of hatching success, developmental delay, reduction of body length, frequency of edema, and morphological abnormalities. Median lethal concentrations (LC50s; 96-h) of 3.68 and 10.21 were determined for acid and alkaline pH, respectively. Embryo survival appeared to be relatively resistant to oxygen depletion with a 96-h LC50 of 0.42 mg/L. However, concentrations of 6 mg/L and below caused edema and developmental retardations. Continuous exposure to UV radiation affected zebrafish development by reducing survival and hatching rate and triggering a series of developmental abnormalities such as pericardial edema and deformities. A 72-h LC50 of 227 mW/m was derived from intensity-response modeling. By generation of concentration-response parameters the authors' data provide a basis for the subsequent assessment of combined effect of environmental stress parameters and chemicals. Environ Toxicol Chem 2017;36:682-690. © 2016 SETAC.

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Section: Uv Radiation Effects On Zebrafish Embryo Survival and Develomentioning

confidence: 99%

Zebrafish embryo tolerance to environmental stress factors—Concentration–dose response analysis of oxygen limitation, pH, and UV‐light irradiation

Andrade

Henriques

Almeida

et al. 2016

Enviro Toxic and Chemistry

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“…Huovinen et al (2001) showed that phototoxicity was dependent on the absorption properties of the PAHs. The maximum absorption spectra are 263, 258, and 270 nm for sulfamethazine (Furusawa 2001), sulfathiazole (Chichiro et al 1981), and sulfamethoxazole (Ulett et al 2003), respectively.…”

Section: Effects Of Uvb Light On Sulfonamide Acute Toxicitymentioning

confidence: 99%

“…Many studies have suggested the importance of cellular partitioning for phototoxicity. Huovinen et al (2001) reported that the bio-accumulation of pyrene, anthracene, and retene before exposure to UV light is essential for the photo-enhanced toxicity of these compounds in daphnids. This report suggested that photosensitization (i.e., photochemistry occurring inside the biota) was more important than photomodification of a compound in the mechanism of photo-enhanced toxicity.…”

Section: -E Homo -E Lumo Gapmentioning

confidence: 99%

“…Photo-enhanced toxicity in polycyclic aromatic hydrocarbons (PAHs) is a well-documented example of the indirect adverse effects of UV irradiation (Hatch and Burton 1999;Huovinen et al 2001;Nikkilä et al 1999;Petersen and Dahllöf 2007). Although less pronounced, metals such as copper, arsenic, and zinc have been shown to be phototoxic (Babu et al 2003;Baud and Beck 2005;Hansen et al 2002).…”

Section: Introductionmentioning

confidence: 99%

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Environmental levels of ultraviolet light potentiate the toxicity of sulfonamide antibiotics in Daphnia magna

Jung

Kim

et al. 2007

Ecotoxicology

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We assessed the phototoxicity of several major sulfonamide antibiotics, i.e., sulfathiazole, sulfamethazine, and sulfamethoxazole, using acute 48 and 96 h Daphnia magna immobilization toxicity test under several indoor and outdoor lighting conditions. The lighting conditions were as follows: (1) fluorescent light only, (2) continuous irradiation with 15 microW/cm(2) UVB, (3) pulsed irradiation with 90 microW/cm(2) UVB for 4 h/d, and (4) natural sunlight (outdoors). Laboratory tests showed that phototoxicity resulting from exposure to continuous UVB light generally increased the acute toxicity of the sulfonamides in D. magna by up to 2.3-fold. However, pulsed UVB exposure resulted in a greater increase in phototoxicity. Compared to fluorescent light only (no UVB), pulsed UVB irradiation (96 h) resulted in 12.0-, 5.8-, and 4.4-fold increases in toxicity for sulfamethazine, sulfathiazole, and sulfamethoxazole, respectively. This suggests that the mode of UV irradiation is more important than the dose (UV-intensity x exposure time) for the photo-enhancement of sulfonamide toxicity. Natural sunlight enhanced the toxicity of the sulfonamides to an even greater degree, likely because of the contribution of UVA light. This study suggests that without taking into account the effects of UV irradiation, it is possible to underestimate the actual consequences of phototoxic sulfonamide antibiotics in the aquatic environment.

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“…UV region of light is known to induce phototoxicity in several chemicals, however, such phenomena have seldom been reported for pharmaceuticals especially in aquatic organisms. UV-B light becomes more important because the flux of solar UV-B has increased as a result not only of stratospheric ozone depletion, but also of greenhouse gases that delay the recovery of ozone layer (Huovinen et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Implication of global environmental changes on chemical toxicity-effect of water temperature, pH, and ultraviolet B irradiation on acute toxicity of several pharmaceuticals in Daphnia magna

et al. 2009

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Global environmental change poses emerging environmental health challenges throughout the world. One of such threats could be found in chemical safety in aquatic ecosystem. In the present study, we evaluated the effect of several environmental factors, such as water pH, temperature and ultraviolet light on the toxicity of pharmaceutical compounds in water, using freshwater invertebrate Daphnia magna. Seven pharmaceuticals including ibuprofen, acetaminophen, lincomycin, ciprofloxacin, enrofloxacin, chlortetracycline and sulfathiazole were chosen as test compounds based on their frequent detection in water. The experimental conditions of environmental parameters were selected within the ranges that could be encountered in temperate environment, i.e., water temperature (15, 21, and 25 degrees C), pH (7.4, 8.3, and 9.2), and UV-B light intensity (continuous irradiation of 15.0 microW/cm(2)). For acetaminophen, enrofloxacin and sulfathiazole, decrease in water pH generally led to increase of acute lethal toxicity, which could be explained by the unionized fraction of pharmaceuticals. Increase of water temperature enhanced the acute toxicity of the acetaminophen, enrofloxacin and chlortetracycline, potentially due to alteration in toxicokinetics of chemicals as well as impact on physiological mechanisms of the test organism. The presence of UV-B light significantly increased the toxicity of sulfathiazole, which could be explained by photo-modification of this chemical that lead to oxidative stress. Under the UV light, however, acute toxicity of enrofloxacin decreased, which might be due to photo-degradation. Since changing environmental conditions could affect exposure and concentration-response profile of environmental contaminants, such conditions should be identified and evaluated in order to better manage ecosystem health under changing global environment.

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Photoinduced toxicity of retene to Daphnia magna under enhanced UV-B radiation

Cited by 47 publications

References 32 publications

Zebrafish embryo tolerance to environmental stress factors—Concentration–dose response analysis of oxygen limitation, pH, and UV‐light irradiation

Zebrafish embryo tolerance to environmental stress factors—Concentration–dose response analysis of oxygen limitation, pH, and UV‐light irradiation

Environmental levels of ultraviolet light potentiate the toxicity of sulfonamide antibiotics in Daphnia magna

Implication of global environmental changes on chemical toxicity-effect of water temperature, pH, and ultraviolet B irradiation on acute toxicity of several pharmaceuticals in Daphnia magna

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