Photoinduced α‐Alkylation of Tetrahydroisoquinolines with Organoboron Reagent Enabled by Organic Photocatalyst

Abstract

We describe an efficient method for α-functionalization of Naryl-tetrahydroisoquinolines under visible-light-irradiation catalyzed by organic photocatalyst. This protocol provides a concise and environmental approach for the rapid allylation and benzylation of N-aryl-tetrahydroisoquinolines, and shows broad substrate scope. Stable organoboron reagents have shown their ability in the construction of challenging Csp 3 À Csp 3 bond. The load of the photocatalyst is low and the oxidant is inexpensive and less toxic.