Photoinitiated Graft Poly(organophosphazenes): Functionalized Immobilization Substrates for the Binding of Amines, Proteins, and Metals

Allcock, Harry R.; Nelson, Constance J.; Coggio, William D.

doi:10.1021/cm00040a029

Cited by 27 publications

(24 citation statements)

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“…2 However, when the phosphazene polymer [NP(O 2 C 12 H 8 )] n was prepared using polydichlorophosphazene obtained by the method described by Allcock et al 11 (based on the heating of pure melted [N 3 P 3 Cl 6 ] without the addition of acidic promoters), we obtained a product 3 also with PTHF, although the amounts were practically negligible (x ϭ 0.05). Additionally, we observed that, in this case, the chlorine substitution was slower, and the M w of the product was almost double than that of 1, which is consistent with the published M w values of polyphosphazenes prepared from [NPCl 2 ] n obtained by solution polymerization 2 or by melting polymerization 11,13 of [N 3 P 3 Cl 6 ].…”

Section: Resultsmentioning

confidence: 84%

On the presence of polytetrahydrofuran in the polyspiro-phosphazenes [NP(O2C12H8)]n prepared from [NPCl2]n and 2,2?-dihydroxybiphenyl in THF as solvent

Carriedo

Alonso

Elipe

et al. 2000

J. Appl. Polym. Sci.

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Polydichlorophosphazene [NPCl 2 ] n reacts with the diphenol 2,2Ј-(HO)C 6 H 4 -C 6 H 4 (OH) in THF in the presence of K 2 CO 3 to give the polymers [NP(O 2 C 12 H 8 ) ⅐ x(OC 4 H 8 )] n (1) that contain variable ammouts of polytetrahydrofuran (PTHF) with x ranging from 0.05 to 0.8. This PTHF content (x) depends on the method followed to prepare the THF solutions of [NPCl 2 ] n used for the reactions with the biphenol and can be made negligibly small, forming these solutions in the presence of K 2 CO 3 . This reveals the presence in the [NPCl 2 ] n of acidic species capable of catalyzing the ring opening polymerization of THF. Polyphosphazene [NP(O 2 C 12 H 8 )] n (2) was prepared completely free of PTHF using dioxane as solvent. A comparison of the thermal behavior and morphological data of the polymers 1, 2, PTHF (5), and mixtures of [NP(O 2 C 12 H 8 )] n ϩ x(OC 4 H 8 ) m (4) revealed that the products 1 are strongly interacting polymer blends and ruled out the possibility of block copolymers.

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Section: Resultsmentioning

confidence: 84%

On the presence of polytetrahydrofuran in the polyspiro-phosphazenes [NP(O2C12H8)]n prepared from [NPCl2]n and 2,2?-dihydroxybiphenyl in THF as solvent

Carriedo

Alonso

Elipe

et al. 2000

J. Appl. Polym. Sci.

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“…An initial step in which mobile hydrogen atoms (usually present as alkyl radicals in the para position of the phenoxy substituents of poly(aryloxyphosphazene)s are removed by a variety of processes to induce the formation of phosphazene macroradicals; this initial process can also be induced by suitable photosensitizers (e.g., benzophenone [65,66] originates organic polymers grafted onto the surface of polyphosphazene films. An initial step in which mobile hydrogen atoms (usually present as alkyl radicals in the para position of the phenoxy substituents of poly(aryloxyphosphazene)s are removed by a variety of processes to induce the formation of phosphazene macroradicals; this initial process can also be induced by suitable photosensitizers (e.g., benzophenone [65,66] originates organic polymers grafted onto the surface of polyphosphazene films.…”

Section: Surface Modification Of Pop Films Through Electromagnetic Ramentioning

confidence: 99%

Phosphazenes and Surfaces

Gleria

Milani

Bertani

et al. 2008

Polyphosphazenes for Biomedical Applications

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“…The photolytic reactions of [NP(OC 6 H 4 CH 3 -p) n have also been used to bind proteins to polyphosphazene surfaces. [53] Photo-grafting of glycidyl methacrylate gave [NP(OC 6 H 4 CH 2 (CH 2 C(CH 3 )-COOCH 2 -oxirane) x ) 2 ] n . The epoxide functionality was then employed to bind a number of amines to the surface of polymer films, including Protein A.…”

Section: Protein Binding To Surface Functional Sitesmentioning

confidence: 99%

The synthesis of functional polyphosphazenes and their surfaces

Allcock

1998

Appl. Organometal. Chem.

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The macromolecular substitution approach for the synthesis of polyphosphazenes provides access to many different polymers. However, it precludes the use of reagents that contain two or more functional groups because such compounds would cause extensive crosslinking of the chains. This presents a problem because many of the uses for which polyphosphazenes seem ideally suited require the presence of-OH,-COOH,-NH 2 ,-SO 3 H,-PR 2 and other functional units in the side-chain structure. We have developed two approaches to introduce such active sites: (1) protection-deprotection reactions; and (2) direct reactions of active reagents with the organic side-groups of non-functional poly(organophosphazenes). These methods have been applied both at the molecular level and in the form of reactions carried out only at polymer surfaces. The resultant polymers have special properties that are valuable in the microencapsulation of sensitive biological agents; in the formation of hydrophobic, hydrophilic, or adhesive surfaces; in crosslinking reactions; and in the development of solid polymer electrolytes, bio-erodible polymers, pH-triggered hydrogels, polymer blends and interpenetrating polymer networks. Overall, more than 700 different polyphosphazenes are now known, and a large number of these are functional macromolecules targeted for specific property combinations and uses.

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Photoinitiated Graft Poly(organophosphazenes): Functionalized Immobilization Substrates for the Binding of Amines, Proteins, and Metals

Cited by 27 publications

References 0 publications

On the presence of polytetrahydrofuran in the polyspiro-phosphazenes [NP(O2C12H8)]n prepared from [NPCl2]n and 2,2?-dihydroxybiphenyl in THF as solvent

On the presence of polytetrahydrofuran in the polyspiro-phosphazenes [NP(O2C12H8)]n prepared from [NPCl2]n and 2,2?-dihydroxybiphenyl in THF as solvent

Phosphazenes and Surfaces

The synthesis of functional polyphosphazenes and their surfaces

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