Silicone hydrogels have been extensively used in biomedical applications. However, protein adsorption and bacterial contamination are the major drawbacks of silicone hydrogel due to their hydrophobic property. Matrix assisted pulsed laser evaporation (MAPLE) has shown the capability for depositing soft marerials like organic and biomolecules. In this paper, we use MAPLE processes to deposit silver nanoparticles (Ag NPs) modified with polyvinylpyrrolidone (PVP) on silicone. The average particle size of Ag nanoparticles deposited by MAPLE was estimated at 15±3 nm. The mechanical properties of the nanocomposite coated silicone hydrogel were investigated and the value of Young's modulus was found to be 0.62 MPa. Moreover the protein adsorption on the nanocomposite coated silicone hydrogel formed by two step was found to be 14.109 μg/cm 2 .