Photoluminescence studies of a Terbium(III) complex as a fluorescent probe for DNA detection

Khorasani-Motlagh, Mozhgan; Noroozifar, Meissam; Niroomand, Sona; Moodi, Asieh

doi:10.1016/j.jlumin.2013.04.011

Cited by 40 publications

(15 citation statements)

References 37 publications

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“…To address these problems, researchers are designing new chemotherapeutic agents based on transition metal ions. Many metal complexes exhibit their effect as drugs by binding to DNA or proteins using different binding methods, and is the basic mode of action of many well known drugs . The DNA interaction phenomenon may be useful in the design of selective and effective new pharmacological compounds.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

et al. 2019

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Novel palladium(II) complexes (7a–7e) of substituted quinoline derivatives were synthesized. The complexes were characterized using various techniques such as thermogravimetric analysis (TGA), elemental analysis, conductance measurement, mass, absorption, infra‐red (IR), 1H NMR, 13C NMR and energy‐dispersive X‐ray spectroscopy (EDX). Complexes for herring sperm DNA (HS DNA) binding were explored and absorption titration and the binding constant (Kb) as well as Gibb's free energy were evaluated. Complex 7d exhibited the highest binding constant, therefore the thermodynamic parameters of 7d at different temperatures were evaluated. To support the results of the absorption titration, fluorescence titration, viscosity measurement and molecular docking studies were performed. The fluorescence quenching data as evaluated from Stern–Volmer equation were used to calculate KSV, Kf and the number of binding sites. The results of all these studies were in good agreement with the absorption study. DNA electrophoretic mobility was performed to explore the possible application of metal complexes as artificial metallonucleases. The antibacterial activity of the complexes was accessed against different pathogenic bacteria and cytotoxicity was measured using brine shrimp and S. pombe.

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Section: Introductionmentioning

confidence: 99%

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

et al. 2019

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“…Drugs that can bind with DNA are known to also be effective as anti-tumor, antivirus and antibacterial therapeutic agents [2]. In this view, metal complexes that can act as antibacterial, cleaving or binding agents of DNA are of great interest.…”

Section: Introductionmentioning

confidence: 99%

Crystal structures of o , o ′-( N , N ′-dipicolinyldene)diazadiphenyl disulfide and its copper (II) complex: Antioxidant, antibacterial and DNA-binding properties

Moosun

Jhaumeer‐Laulloo

Hosten

et al. 2015

Inorganica Chimica Acta

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“…Evidence for the mode of binding of the complexes to FS‐DNA was also obtained through emission quenching experiments . The experiment of DNA competitive binding with ethidium bromide (EtBr) was carried out in buffer by keeping [DNA]/[EtBr] = 2.5 ([DNA] = 2.5 μM, [EtBr] = 1 μM) and varying the concentrations of the metal complexes (0–17 μM).…”

Section: Methodsmentioning

confidence: 99%

Two Ho(III) and Co(II) complexes constructed from bis(triazol‐1‐yl)benzoic acid with structurally similar carboxyl ligands: Syntheses, structures and biological activities

Zhu

Wang

Meng

et al. 2018

Applied Organom Chemis

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Two new complexes, [Ho(L) 2 NO 3 ] n (1) and [Co(L′) 2 Cl 4 ] n (2) (HL = 3,5bis(triazol-1-yl)benzoic acid, HL′ = 2,4-bis(triazol-1-yl)benzoic acid), have been synthesized and characterized. Interactions with DNA through absorption titration experiments, fluorescence spectra, viscosity measurements and a molecular docking study were examined. The results suggested that complexes 1 and 2 interact with DNA in a partial intercalation mode. DNA binding affinity was determined using k b values, which indicated that the binding activity of the complexes to DNA was complex 2 (k b = 1.93 × 10 4 ) > complex 1 (k b = 1.06 × 10 4 ). Gel electrophoresis assay demonstrated that the complexes have the ability to cleave pBR322 DNA. Apoptotic assay indicated that the complexes can induce programmed death of Hela cells (human cervix carcinoma cells). A cytotoxicity study indicated that complex 2 shows a greater inhibitory rate of Hela cells than complex 1 and the cytotoxicity of both 1 and 2 showed time dependence. Especially, the efficacy of complex 2 was shown to be higher than that of cisplatin at 72 h.

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Photoluminescence studies of a Terbium(III) complex as a fluorescent probe for DNA detection

Cited by 40 publications

References 37 publications

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

Crystal structures of o , o ′-( N , N ′-dipicolinyldene)diazadiphenyl disulfide and its copper (II) complex: Antioxidant, antibacterial and DNA-binding properties

Two Ho(III) and Co(II) complexes constructed from bis(triazol‐1‐yl)benzoic acid with structurally similar carboxyl ligands: Syntheses, structures and biological activities

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