Photoluminescent arginine‐functionalized polycitrate with enhanced cell activity and hemocompatibility for live cell bioimaging

Wang, Min; Guo, Yi; Peter, X.; Lei, Bo

doi:10.1002/jbm.a.36512

Cited by 9 publications

(2 citation statements)

References 35 publications

(59 reference statements)

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“…Notably, PCGA selectively stained lysosomes within cells, indicating its potential in lysosome-targeted bioimaging applications. [252] The same group further developed PCGA nanoparticles carrying an opioid peptide, Dynorphin A1-8 as a treatment against cerebral ischemia/reperfusion injury. The nanoparticles demonstrated promising therapeutic effects in the middle cerebral artery occlusion (MCAO) in rats.…”

Section: Photoluminescent Propertiesmentioning

confidence: 99%

Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations

Xu,

Yan,

Gerhard

et al. 2024

Advanced Materials

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Citrate‐based biodegradable polymers have emerged as a distinctive biomaterial platform with tremendous potential for diverse medical applications. By harnessing their versatile chemistry, these polymers exhibit a wide range of material and bioactive properties, enabling them to regulate cell metabolism and stem cell differentiation through energy metabolism, metabonegenesis, angiogenesis and immunomodulation. Moreover, the recent U.S. Food and Drug Administration (FDA) clearance of the biodegradable poly(octamethylene citrate) (POC)/hydroxyapatite‐based orthopedic fixation devices represent a translational research milestone for biomaterial science. POC joins a short list of biodegradable synthetic polymers that have ever been authorized by the FDA for use in humans. The clinical success of POC has sparked enthusiasm and accelerated the development of next‐generation citrate‐based biomaterials. This review presents a comprehensive, forward‐thinking discussion on the pivotal role of citrate chemistry and metabolism in various tissue regeneration and on the development of functional citrate‐based metabotissugenic biomaterials for regenerative engineering applications.This article is protected by copyright. All rights reserved

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Section: Photoluminescent Propertiesmentioning

confidence: 99%

Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations

Xu,

Yan,

Gerhard

et al. 2024

Advanced Materials

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“…Since the unexpected fluorescence property of the product from the condensation reaction between CA and amino acids was first demonstrated by our group in 2009 [ 16 ], a number of related works have been reported [ 12 , 13 , 15 , 93 – 104 ]. The initial work started with an occasional observation of blue fluorescence emitted from the condensation product of CA, L-cysteine, and 1,8-octanediol under strong summer sunlight.…”

Section: Citric Acid-based Intrinsic Band-shifting Photoluminescent M...mentioning

confidence: 99%

Citric Acid-Based Intrinsic Band-Shifting Photoluminescent Materials

et al. 2023

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Citric acid, an important metabolite with abundant reactive groups, has been demonstrated as a promising starting material to synthesize diverse photoluminescent materials including small molecules, polymers, and carbon dots. The unique citrate chemistry enables the development of a series of citric acid-based molecules and nanomaterials with intriguing intrinsic band-shifting behavior, where the emission wavelength shifts as the excitation wavelength increases, ideal for chromatic imaging and many other applications. In this review, we discuss the concept of “intrinsic band-shifting photoluminescent materials”, introduce the recent advances in citric acid-based intrinsic band-shifting materials, and discuss their potential applications such as chromatic imaging and multimodal sensing. It is our hope that the insightful and forward-thinking discussion in this review will spur the innovation and applications of the unique band-shifting photoluminescent materials.

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Enhanced Physiological Stability and Long‐Term Toxicity/Biodegradation In Vitro/In Vivo of Monodispersed Glycerolphosphate‐Functionalized Bioactive Glass Nanoparticles

Xue

Zhang

Niu

et al. 2019

Part & Part Syst Charact

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Monodispersed bioactive glass nanoparticles (BGNs) have received much attention in various biomedical applications such as tissue regeneration, drug/gene delivery, bioimaging, and cancer therapy. However, the poor dispersion stability of BGNs in a physiological environment has limited their wide biomedical applications. The long‐term in vitro/in vivo toxicity and biodegradation of BGNs are also not clear. Monodispersed glycerolphosphate‐functionalized BGNs (GP‐BGN) are synthesized and their stability under physiological environment in vitro, and long‐term biodegradation behavior in vitro and in vivo are investigated herein. GP‐BGN shows significantly enhanced particles stability in physiological environment, good hemocompatibility and cellular biocompatibility, as well as high cellular uptake ability. GP‐BGN also exhibits long‐term biodegradation behavior in vitro/in vivo and negligible biotoxicity (tissue and blood toxicity). This study demonstrates that monodispersed surface‐functionalized BGNs could be used as biocompatible and biodegradable nanomaterials for long‐term safe bioimaging and disease therapy.

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Photoluminescent arginine‐functionalized polycitrate with enhanced cell activity and hemocompatibility for live cell bioimaging

Cited by 9 publications

References 35 publications

Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations

Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations

Citric Acid-Based Intrinsic Band-Shifting Photoluminescent Materials

Enhanced Physiological Stability and Long‐Term Toxicity/Biodegradation In Vitro/In Vivo of Monodispersed Glycerolphosphate‐Functionalized Bioactive Glass Nanoparticles

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