Photometric and Colorimetric Cyanide Detection Sensor Using Amine Based Nitrobenzoxadiazole Derivatives

Abstract

The fluorescent probes 7‐nitro‐N‐phenylbenzo[c][1,2,5]oxadiazol‐4‐amine (1), and 4‐((7‐nitrobenzo[c][1,2,5]oxadiazol‐4‐yl)amino)benzonitrile (2) were synthesised for the detection of cyanide ion (CN−). A new correlative approach with nitrobenzoxadiazole (NBD)‐based probes to detecting CN− by the Donor‐Acceptor D‐A (1) and Acceptor‐Donor‐Acceptor (A‐D‐A) (2) with the aid of DFT calculations are reported. Given their design features, these NBD probes 1 and 2 provide useful insights into the dual‐channel (fluorometric and colorimetric) sensor activity with good selectivity for CN− detection, considerable fluorescence amplification in the presence of CN− ion, and the desirable “Off–on” fluorescent responses toward CN− in the semi‐aqueous medium. The photophysical studies confirmed the A‐D‐A type molecule has a detection limit 0.163 μM for CN− sensing, which is lower than the WHO′s cyanide in water permitted limit. The simple synthetic probes 1 and 2 will offer up new possibilities for industrial effluent CN− detection and bio‐imaging of CN− in a variety of cell lines. This will undoubtedly aid in the understanding of the basic mechanism of CN− poisoning in the bloodstream.

Ultrasensitive Monitoring of Cyanide Concentrations in Water Using a Aucore–Agshell Hybrid-Coating-Based Fiber Optical Sensor

“…The fiber optical sensors with Au@Ag exhibited a great advantage of ultrahigh sensitivity over conventional methodologies, such as using fluorometry and colorimetry − while ensuring sufficient operation range of CN – concentration for CN – quantitative sensors. Table summarizes the recently reported cyanide detection compared with the results presented in this work.…”

Detection of cyanide and sulfide ions by different mechanisms using a fluorescent chemical sensor containing a fluorophore and a potential ligand for metal complexes

“…Depending upon the type of transducer, sensors can involve optical methods such as colorimetry, uorescence, chemiluminescence, and label-free detection; electrochemical sensors; and piezoelectric sensors. Among these sensor categories, [10][11][12][13][14][15] uorescence sensors are highly sensitive and facilitate direct measurement of CN − and S 2− ions at mg L −1 levels. The detection is based on the affinity of CN − and S 2− ions with metal nanoparticles such as gold and silver.…”