Photometric method for determination of acidity constants through integral spectra analysis

Zevatskiy, Yuriy; Ruzanov, D. O.; Samoylov, Denis V.

doi:10.1016/j.saa.2015.01.045

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…[18][19][20]. Zevatskiy [21] describes Standard Spectrophotometric Method (SSM) for obtaining pK a . This classical method is based on measuring the UV-VIS absorption spectra of prototropic form mixtures at several pH values in the vicinity of the assumed pK a .…”

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confidence: 99%

Multiple dissociation constants of the Intepirdine hydrochloride using regression of multiwavelength spectrophotometric pH-titration data

Meloun

Pilařová

Bureš

et al. 2018

Journal of Molecular Liquids

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This manuscript has not been previously published in any language anywhere and it is not under consideration by another journal. To date, no spectra, no dissociation constants or no pHdistribution diagrams of the relative concentration of variously protonated ions of the drug Intepirdine hydrochloride INN.HCl have been published. 1) Significance of the work: Medicine and pharmacology needs physical constants (spectra, pK´s, solubility, etc.) of new drugs. 2) Novelty of the work: INN.HCl is used for the treatment of mild to moderate Alzheimer's disease and dementia with Lewy bodies. Acid-base equilibria were studied with UV-metric spectra analysis and pH-metric titration analysis. Three pK T a1 , pK T a2 , pK T a3 , of INN.HCl were determined at 25ºC and 37ºC in an aqueous medium. The number of variously protonated species was estimated from the rank of the UV-absorbance matrix. 3) Contribution to the field: Knowledge of the possible ionization states of a pharmaceutical substance, embodied in pK a , is vital for understanding properties essential to drug development.

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mentioning

confidence: 99%

Multiple dissociation constants of the Intepirdine hydrochloride using regression of multiwavelength spectrophotometric pH-titration data

Meloun

Pilařová

Bureš

et al. 2018

Journal of Molecular Liquids

View full text Add to dashboard Cite

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“…Uno de los métodos experimentales más utilizados es la espectrofotometría, la cual es una de las técnicas más empleadas para la investigación de equilibrio en solución, que permite el estudio de los equilibrios polipróticos [50]. Este método es ampliamente usado por su sencillez, requiere de un equipo relativamente accesible y se puede trabajar con la concentración de un compuesto en concentraciones micro molares [51]. Está basado en la medición de la absorción del espectro UV-Vis de mezclas a diferentes valores de pH, en el entorno del valor de pKa asumido.…”

Section: Constantes De Acidezunclassified

Determinación de las propiedades fisicoquímicas de algunas dihidroxi-antraquinonas

Rivas Sánchez

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Quantification of pH-dependent speciation of organic compounds with spectroscopy and chemometrics

Ritschel

Totsche

2017

Chemosphere

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Photometric method for determination of acidity constants through integral spectra analysis

Cited by 4 publications

References 36 publications

Multiple dissociation constants of the Intepirdine hydrochloride using regression of multiwavelength spectrophotometric pH-titration data

Multiple dissociation constants of the Intepirdine hydrochloride using regression of multiwavelength spectrophotometric pH-titration data

Determinación de las propiedades fisicoquímicas de algunas dihidroxi-antraquinonas

Quantification of pH-dependent speciation of organic compounds with spectroscopy and chemometrics

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