This review focuses on nuclear reactions in astrophysics and, more specifically, on reactions with light ions (nucleons and α particles) proceeding via the strong interaction. It is intended to present the basic definitions essential for studies in nuclear astrophysics, to point out the differences between nuclear reactions taking place in stars and in a terrestrial laboratory, and to illustrate some of the challenges to be faced in theoretical and experimental studies of those reactions. The discussion revolves around the relevant quantities for astrophysics, which are the astrophysical reaction rates. The sensitivity of the reaction rates to the uncertainties in the prediction of various nuclear properties is explored and some guidelines for experimentalists are also provided.Caminante, son tus huellas el camino, y nada más; Caminante, no hay camino, se hace camino al andar.Al andar se hace camino y al volver la vista atrás se ve la senda que nunca se ha de volver de pisar. Caminante, no hay camino sino estelas en la mar.