Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

Lee, Sungkyu; Yoo, Jounghyun; Bae, Gunhyu; Thangam, Ramar; Heo, Jeongyun; Park, Jung Yeon; Choi, Honghwan; Kim, Chowon; An, Jusung; Kim, Jungryun; Mun, Kwang Rok; Shin, Seungyong; Zhang, Kunyu; Zhao, Pengchao; Kim, Yuri; Kang, Nayeon; Han, Seong-Beom; Kim, Dahee; Yoon, Jiwon; Kang, Misun; Kim, Jihwan; Yang, Letao; Karamikamkar, Solmaz; Kim, Jinjoo; Zhu, Yangzhi; Najafabadi, Alireza Hassani; Song, Guosheng; Kim, Dong-Hwee; Lee, Ki-Bum; Oh, Soong Ju; Jung, Hyun-Do; Song, Hyun-Cheol; Jang, Woo Young; Bian, Liming; Chu, Zhiqin; Yoon, Juyoung; Kim, Jong Seung; Zhang, Yu Shrike; Kim, Yongju; Jang, Ho Seong; Kim, Sehoon; Kang, Heemin

doi:10.1016/j.bioactmat.2023.12.011

Bioactive Materials

2024

DOI: 10.1016/j.bioactmat.2023.12.011

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Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

Sungkyu Lee,

Jounghyun Yoo,

Gunhyu Bae

et al.

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Cited by 2 publications

References 99 publications

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Self‐Assembled Aza‐Boron‐Dipyrromethene‐Based H₂S Prodrug for Synergistic Ferroptosis‐Enabled Gas and Sonodynamic Tumor Therapies

Zhao,

Bian,

Zhang

et al. 2024

Advanced Science

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Glioblastoma multiforme (GBM) is the most aggressive and lethal subtype of gliomas of the central nervous system. The efficacy of sonodynamic therapy (SDT) against GBM is significantly reduced by the expression of apoptosis‐inhibitory proteins in GBM cells. In this study, an intelligent nanoplatform (denoted as Aza‐BD@PC NPs) based on the aza‐boron‐dipyrromethene dye and phenyl chlorothionocarbonate‐modified DSPE‐PEG molecules is developed for synergistic ferroptosis‐enabled gas therapy (GT) and SDT of GBM. Once internalized by GBM cells, Aza‐BD@PC NPs showed effective cysteine (Cys) consumption and Cys‐triggered hydrogen sulfide (H2S) release for ferroptosis‐enabled GT, thereby disrupting homeostasis in the intracellular environment, affecting GBM cell metabolism, and inhibiting GBM cell proliferation. Additionally, the released Aza‐BD generated abundant singlet oxygen (1O2) under ultrasound irradiation for favorable SDT. In vivo and in vitro evaluations demonstrated that the combined functions of Cys consumption, H2S production, and 1O2 production induced significant death of GBM cells and markedly inhibited tumor growth, with an impressive inhibition rate of up to 97.5%. Collectively, this study constructed a cascade nanoreactor with satisfactory Cys depletion performance, excellent H2S release capability, and prominent reactive oxygen species production ability under ultrasound irradiation for the synergistic ferroptosis‐enabled GT and SDT of gliomas.

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Self‐Assembled Aza‐Boron‐Dipyrromethene‐Based H₂S Prodrug for Synergistic Ferroptosis‐Enabled Gas and Sonodynamic Tumor Therapies

Zhao,

Bian,

Zhang

et al. 2024

Advanced Science

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A cuproptosis-based nanomedicine suppresses triple negative breast cancers by regulating tumor microenvironment and eliminating cancer stem cells

Xiao,

Wang,

et al. 2025

Biomaterials

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Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

Cited by 2 publications

References 99 publications

Self‐Assembled Aza‐Boron‐Dipyrromethene‐Based H₂S Prodrug for Synergistic Ferroptosis‐Enabled Gas and Sonodynamic Tumor Therapies

Self‐Assembled Aza‐Boron‐Dipyrromethene‐Based H₂S Prodrug for Synergistic Ferroptosis‐Enabled Gas and Sonodynamic Tumor Therapies

A cuproptosis-based nanomedicine suppresses triple negative breast cancers by regulating tumor microenvironment and eliminating cancer stem cells

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Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

Cited by 2 publications

References 99 publications

Self‐Assembled Aza‐Boron‐Dipyrromethene‐Based H2S Prodrug for Synergistic Ferroptosis‐Enabled Gas and Sonodynamic Tumor Therapies

Self‐Assembled Aza‐Boron‐Dipyrromethene‐Based H2S Prodrug for Synergistic Ferroptosis‐Enabled Gas and Sonodynamic Tumor Therapies

A cuproptosis-based nanomedicine suppresses triple negative breast cancers by regulating tumor microenvironment and eliminating cancer stem cells

Contact Info

Product

Resources

About

Self‐Assembled Aza‐Boron‐Dipyrromethene‐Based H₂S Prodrug for Synergistic Ferroptosis‐Enabled Gas and Sonodynamic Tumor Therapies

Self‐Assembled Aza‐Boron‐Dipyrromethene‐Based H₂S Prodrug for Synergistic Ferroptosis‐Enabled Gas and Sonodynamic Tumor Therapies