Photonic crystal microcavity sensor for ultracompact monitoring of reaction kinetics and protein concentration

Zlatanovic, Sanja; Mirkarimi, Laura; Sigalas, M. M.; Bynum, Maggie A.; Chow, Edmond; Robotti, Karla M.; Burr, Geoffrey W.; Esener, Sadik C.; Grot, Annette

doi:10.1016/j.snb.2009.06.007

Cited by 111 publications

(95 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The sensitivity is measured by the magnitude of the resonance wavelength shift for a fixed concentration, as well as the minimum concentration that can be detected. Initial PC designs focused on donor defect modes such as in a L4 microcavity (4 missing holes) 7 or acceptor defect modes 8 as in H1 defect cavities, in a triangular lattice of air holes. Later, designs increased the analyte overlap with cavity modes, also referred as fill fraction, for enhanced sensitivity.…”

mentioning

confidence: 99%

Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors

Chakravarty

Hosseini

et al. 2014

Applied Physics Letters

View full text Add to dashboard Cite

We analyze the contributions of quality factor, fill fraction, and group index of chip-integrated resonance microcavity devices, to the detection limit for bulk chemical sensing and the minimum detectable biomolecule concentration in biosensing. We analyze the contributions from analyte absorbance, as well as from temperature and spectral noise. Slow light in two-dimensional photonic crystals provide opportunities for significant reduction of the detection limit below 1 Â 10 À7 RIU (refractive index unit) which can enable highly sensitive sensors in diverse application areas. We demonstrate experimentally detected concentration of 1 fM (67 fg/ml) for the binding between biotin and avidin, the lowest reported till date. V C 2014 AIP Publishing LLC.[http://dx.doi.org/10.1063/1.4875903]In recent years, various integrated optical devices have been developed for label-free bio-sensing such as ring resonators, 1 wire waveguides, 2 surface plasmon resonance (SPR), 3 and photonic crystal (PC) microcavities. [4][5][6] The detection principle is based on a change in the refractive index, and hence the transduced signal caused by the specific binding of the biomolecule of interest to its specific conjugate biomolecule receptor bound to the optical device substrate. The device sensitivity is determined by the magnitude of light-matter interaction.For early bio-pathogen detection, a sensor with highest sensitivity is desired. The sensitivity is measured by the magnitude of the resonance wavelength shift for a fixed concentration, as well as the minimum concentration that can be detected. Initial PC designs focused on donor defect modes such as in a L4 microcavity (4 missing holes) 7 or acceptor defect modes 8 as in H1 defect cavities, in a triangular lattice of air holes. Later, designs increased the analyte overlap with cavity modes, also referred as fill fraction, for enhanced sensitivity. 9 Recently, we showed that an increased cavity length results in an increase in the quality factor (Q-factor) of the resonance mode 10-12 that allows smaller changes in concentration to be distinguished. The high Q enhances the interaction time between the optical mode and the analyte while the larger mode volume results in larger fill fraction, both factors resulting in higher sensitivity We demonstrated experimentally in our side-coupled two-dimensional (2D) PC cavity-waveguide architecture that the magnitude of the slow-down factor in the coupling waveguide contributes to enhanced light-matter interaction. 11 Over successive generations, we demonstrated experimentally 50 fM (3.35 pg/ml) sensitivity to the detection of the specific binding of avidin to biotin 12 with a L55 type PC microcavity (55 missing holes).A question still remains about the relative merits of Q-factor, fill fraction, and group index, when considered in conjunction with different sources of noise in measurements, in order to achieve low detection limits in chip-integrated photonic sensors. While an increased modal overlap with the analyte lowers the detection limit...

show abstract

mentioning

confidence: 99%

Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors

Chakravarty

Hosseini

et al. 2014

Applied Physics Letters

View full text Add to dashboard Cite

show abstract

“…It means 15% improvement is observed for a nano-ring resonator of three-hole coupling distance than the one of two-hole coupling distance in terms of the minimum detectable biomolecule weight. According to this calculated detection limit, it is about ten times better than previous reported data [16], [19]. In future implementation, a lab-on-a-chip (LoC) device comprising microfluidic channel integrated on the nanoring resonator is expected as a promising sensor for biochemical sensing such as DNA and protein detection.…”

Section: B Nano-ring Resonator With Three-hole Coupling Distancementioning

confidence: 63%

“…It has been reported that the similar 2-D PC microcavity resonator can detect protein down to 2.5 fg [16], a gold nanoparticle of 10 nm in diameter [17], and ion concentration absorbed in ion-selective polymer coated on the resonator [18]. Recently S. Zlatanovic reported detection limit of anti-biotin as less as 20 pM, corresponding to less than 4.5 fg of bound material on the sensor surface of 50 and fewer than 80 molecules in the modal volume of the microcavity [19].…”

Section: Introductionmentioning

confidence: 99%

Computational Study of Photonic Crystals Nano-Ring Resonator for Biochemical Sensing

2010

View full text Add to dashboard Cite

Abstract-We investigated the characteristics of photonic crystals (PCs) nano-ring resonators as biochemical sensors theoretically. The new nano-ring resonators were formed by removing holes of a hexagon from a two-dimensional (2-D) silicon PC slab in hexagonal lattice. Resonant peak with quality factor of about 3000 is reported. Biomolecules, e.g., DNAs, trapped in a hole functionalized with molecule probes made the wavelength shift of resonant peak derived in the output terminal. The sensitivity of various sensing holes along the nano-ring was characterized. This new PC nano-ring resonator demonstrated promising features as a biochemical sensor.

show abstract

“…20 Also, disk and ring resonators excited optically at the near infrared have been studied as sensors. 21,22 In fact, these types of sensors have been able to probe nanoparticles of a few tens of nanometers in size.…”

Section: Resultsmentioning

confidence: 99%

Whispering gallery modes for elastic waves in disk resonators

Kaproulias

Sigalas

2011

AIP Advances

View full text Add to dashboard Cite

The resonant modes of elastic waves in disk resonators are computationally studied with the finite difference time domain method. Different materials examined for the disk such as platinum and silicon. The effect of a glass substrate is also important especially in the case of silicon disks because of the similarity of sound velocities and mass densities between the two materials. The possibility of using those structures as sensors is also considered

show abstract

Photonic crystal microcavity sensor for ultracompact monitoring of reaction kinetics and protein concentration

Cited by 111 publications

References 16 publications

Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors

Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors

Computational Study of Photonic Crystals Nano-Ring Resonator for Biochemical Sensing

Whispering gallery modes for elastic waves in disk resonators

Contact Info

Product

Resources

About