Photonic Crystal Optical Tweezers with High Efficiency for Live Biological Samples and Viability Characterization

Jing, Peifeng; Wu, Jingda; Liu, Gary W.; Keeler, Ethan G.; Pun, Suzie H.; Lin, Lih Y.

doi:10.1038/srep19924

Cited by 48 publications

(28 citation statements)

References 31 publications

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“…6,7 Amongst these, optical schemes have demonstrated the highest efficiency in terms of the minimum size of the trapped objects and low energy consumption. [8][9][10]…”

Section: Introductionmentioning

confidence: 99%

Photonic and Plasmonic Nanotweezing of Nano- and Microscale Particles

et al. 2017

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The ability to manipulate and sense biological molecules is important in many life science domains, such as single-molecule biophysics, the development of new drugs and cancer detection. Although the manipulation of biological matter at the nanoscale continues to be a challenge, several types of nanotweezers based on different technologies have recently been demonstrated to address this challenge. In particular, photonic and plasmonic nanotweezers are attracting a strong research effort especially because they are efficient and stable, they offer fast response time, and avoid any direct physical contact with the target object to be trapped, thus preventing its disruption or damage. In this paper, we critically review photonic and plasmonic resonant technologies for biomolecule trapping, manipulation, and sensing at the nanoscale, with a special emphasis on hybrid photonic/plasmonic nanodevices allowing a very strong light-matter interaction. The state-of-the-art of competing technologies, e.g., electronic, magnetic, acoustic and carbon nanotube-based nanotweezers, and a description of their applications are also included.

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“…6,7 Amongst these, optical schemes have demonstrated the highest efficiency in terms of the minimum size of the trapped objects and low energy consumption. [8][9][10]…”

Section: Introductionmentioning

confidence: 99%

Photonic and Plasmonic Nanotweezing of Nano- and Microscale Particles

et al. 2017

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“…Furthermore, levels of radiation can reach ~10 7 W/cm 2 which could cause photodamage to cells (opticution) [ 29 ]. There are other variants such as plasmonic tweezers, and photonic crystal waveguides, however they are limited by heat generation and light intensity and could cause cell damage [ 30 ].…”

Section: Techniques and Methodsmentioning

confidence: 99%

“…It is possible, by the use of OET, to reach large-scale parallel manipulation and low-intensity optical trapping. Jing et al [ 30 ] proposed modulated light fields to trap mammalian, yeast, and Escherichia coli cells, on the surface of a two-dimensional photonic crystal. They fabricated a silicon photocrystal coated with parylene-C to planarize the surface and provide an adequate refractive index.…”

Section: Techniques and Methodsmentioning

confidence: 99%

Methods of Micropatterning and Manipulation of Cells for Biomedical Applications

et al. 2017

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Micropatterning and manipulation of mammalian and bacterial cells are important in biomedical studies to perform in vitro assays and to evaluate biochemical processes accurately, establishing the basis for implementing biomedical microelectromechanical systems (bioMEMS), point-of-care (POC) devices, or organs-on-chips (OOC), which impact on neurological, oncological, dermatologic, or tissue engineering issues as part of personalized medicine. Cell patterning represents a crucial step in fundamental and applied biological studies in vitro, hence today there are a myriad of materials and techniques that allow one to immobilize and manipulate cells, imitating the 3D in vivo milieu. This review focuses on current physical cell patterning, plus chemical and a combination of them both that utilizes different materials and cutting-edge micro-nanofabrication methodologies.

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“…Up to now, the optical tweezers (OT) has been becoming an efficient support tool widely applied in physics, chemistry, medical science, nanoscience and biology [1,2]. The idea of OT was first reported in 1970 by Arthur Ashkin [3], a former Bell Laboratories researcher awarded the 2018 Nobel Prize in Physics "for the optical tweezers and their application to biological systems" on October 2 nd , 2018.…”

Section: Introductionmentioning

confidence: 99%

Nonlinear Optical Tweezers As an Optical Method for Controlling Particles with High Trap Efficiency

Quy¹

2019

Comm. in Phys.

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Optical tweezers have seen as an essential tool for the manipulation dielectric microparticles and nanoparticles due to its non-contact action and high resolution of optical force. Up to now, there has been a lot of optical tweezers applications in the fields of biophysics, chemistry, medical science and nanoscience. Recently, optical tweezers have been theoretically and experimentally developing for the nanomechanical characterization of various kinds of biological cells. The configuration of optical tweezers has been day after day improving to enhance the trapping efficiency, spatial and temporal resolution and easy to control trapped objects. In common trend of optical tweezers improvements, we will discuss in detail of the several configurations of nonlinear optical tweezers using nonlinear materials as the added lens. We will also address the advantages of nonlinear optical tweezers, such as enhance optical efficiency, reduce trapping region, simplify controlling all-optical method. Finally, we present discussions about the specific properties of nonlinear optical tweezers used for stretch DNA molecule as example and an ideal to improve nonlinear optical tweezers using thin layer of organic dye proposed for going time.

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Photonic Crystal Optical Tweezers with High Efficiency for Live Biological Samples and Viability Characterization

Cited by 48 publications

References 31 publications

Photonic and Plasmonic Nanotweezing of Nano- and Microscale Particles

Photonic and Plasmonic Nanotweezing of Nano- and Microscale Particles

Methods of Micropatterning and Manipulation of Cells for Biomedical Applications

Nonlinear Optical Tweezers As an Optical Method for Controlling Particles with High Trap Efficiency

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