Photonic crystals on copolymer film for bacteria detection

Li, Nan; Cheng, Xiangju; Brahmendra, Arujun; Prashar, Akriti; Endo, Tatsuro; Guyard, Cyril; Terebiznik, Mauricio R.; Kerman, Kağan

doi:10.1016/j.bios.2012.08.052

Cited by 23 publications

(12 citation statements)

References 24 publications

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“…5). PC structures have gained significant attention as sensitive transducers and have been incorporated into biosensors that capture, detect, and quantify various biological molecules, such as pathogens, 7,47,91–96 DNA, 97–101 proteins, enzymes, 102,103 glucose, 42,104–106 cells, 107,108 toxins, 109 and allergens. 110 …”

Section: Principles Of Pc-based Biosensingmentioning

confidence: 99%

“…This platform can detect H1N1 antigens at a concentration as low as 1 ng mL −1.93 In another study, polymer-2-D pillar PC structures were used to detect L. pneumophila bacteria down to 200 cells per mL. 96 PC-based platforms can also be used for the detection of viruses such as rotavirus, HIV-1, and human papilloma virus-like particles. 92,94,195 To detect HIV-1, a PC surface was functionalized with anti-gp120 antibody for capturing HIV-1 ranging from 10 4 copies per mL to 10 8 copies per mL (Fig.…”

Section: Multi-target Detection Capability For Pc-based Biosensorsmentioning

confidence: 99%

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Photonic crystals: emerging biosensors and their promise for point-of-care applications

et al. 2017

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Biosensors are extensively employed for diagnosing a broad array of diseases and disorders in clinical settings worldwide. The implementation of biosensors at the point-of-care (POC), such as at primary clinics or the bedside, faces impediments because they may require highly trained personnel, have long assay times, large sizes, and high instrumental cost. Thus, there exists a need to develop inexpensive, reliable, user-friendly, and compact biosensing systems at the POC. Biosensors incorporated with photonic crystal (PC) structures hold promise to address many of the aforementioned challenges facing the development of new POC diagnostics. Currently, PC-based biosensors have been employed for detecting a variety of biotargets, such as cells, pathogens, proteins, antibodies, and nucleic acids, with high efficiency and selectivity. In this review, we provide a broad overview of PCs by explaining their structures, fabrication techniques, and sensing principles. Furthermore, we discuss recent applications of PC-based biosensors incorporated with emerging technologies, including telemedicine, flexible and wearable sensing, smart materials and metamaterials. Finally, we discuss current challenges associated with existing biosensors, and provide an outlook for PC-based biosensors and their promise at the POC.

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Section: Principles Of Pc-based Biosensingmentioning

confidence: 99%

Section: Multi-target Detection Capability For Pc-based Biosensorsmentioning

confidence: 99%

Photonic crystals: emerging biosensors and their promise for point-of-care applications

et al. 2017

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“…Microstructures are important for the realization of micro-electro-mechanical-systems, microfluidic devices, photonic crystals, and plasmonic optoelectronic devices, benefitting various biomedical applications such as medical microfluidic filtering devices [1], drug delivery devices [2] and immunochips for bacteria detection [3]. Current technologies for observing these microstructures are based on scanning electron microscope (SEM), confocal microscope and traditional optical microscope.…”

Section: Introductionmentioning

confidence: 99%

Improving resolution of optical coherence tomography for imaging of microstructures

Shen

Wang

et al. 2015

SPIE Proceedings

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Multi-frame superresolution technique has been used to improve the lateral resolution of spectral domain optical coherence tomography (SD-OCT) for imaging of 3D microstructures. By adjusting the voltages applied to and galvanometer scanners in the measurement arm, small lateral imaging positional shifts have been introduced among different C-scans. Utilizing the extracted -plane en face image frames from these specially offset C-scan image sets at the same axial position, we have reconstructed the lateral high resolution image by the efficient multi-frame superresolution technique. To further improve the image quality, we applied the latest K-SVD and bilateral total variation denoising algorithms to the raw SD-OCT lateral images before and along with the superresolution processing, respectively. The performance of the SD-OCT of improved lateral resolution is demonstrated by 3D imaging a microstructure fabricated by photolithography and a double-layer microfluidic device.

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“…These properties encourage more research in this field and further exploration of novel light behaviors in PQCs, such as disorder-enhanced wave transport [11], formation of strong transmission resonances [12], and low pumping threshold lasing from a 2D PQC with an excellent linear polarization [13]. In additional, since traditional PCs have been widely used in biosensors for label-free biomolecule detection, like bacteria, DNA, and insulin [14][15][16][17], PQCs should also have many potential applications in this field due to their excellent optical properties. Thus low-cost mass fabrication of highquality PQCs is of significant interest.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of two kinds of eight-fold photonic quasi-crystals assisted by a specially designed prism

et al. 2013

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We demonstrate that two kinds of 2D eight-fold photonic quasi-crystals (PQCs) can be fabricated by a specially designed prism via single-exposure holographic lithography. The prism with five continuous side surfaces out of common eight symmetrical side surfaces, plus a top surface, is well designed for PQC fabrication. Compared with the traditional method of setting up eight free-space beams in the half-space for an eight-fold PQC fabrication, our specially designed prism reduces the number of beams, avoids the differences of beam-to-beam phases, and simplifies the fabrication process. The theory and computer simulation confirm the patterns of two kinds of PQCs by a single prism illumination recording. Further, these quasi-crystal patterns are successfully verified by experimental results under a scanning electron microscope. In addition, these samples show some good properties, such as uniformity over large area, the implementation of a single defect by underexposure, and symmetry break of the eight dots. Our special prism-assisted holographic lithography technique provides a base for further investigating the optical properties of these novel structures.

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Photonic crystals on copolymer film for bacteria detection

Cited by 23 publications

References 24 publications

Photonic crystals: emerging biosensors and their promise for point-of-care applications

Photonic crystals: emerging biosensors and their promise for point-of-care applications

Improving resolution of optical coherence tomography for imaging of microstructures

Fabrication of two kinds of eight-fold photonic quasi-crystals assisted by a specially designed prism

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