The influence of index contrast variations for obtaining single-mode operation and low threshold in dye doped polymer two dimensional photonic crystal (PhC) lasers is investigated. We consider lasers made from Pyrromethene 597 doped Ormocore imprinted with a rectangular lattice PhC having a cavity in the middle of the crystal structure. We demonstrate that the index contrast, neff,high/neff,low, is an essential parameter for achieving low threshold, and we identify a trade-off between low threshold and single-mode operation.