Photonic Needles for Light Delivery in Deep Tissue-like Media

Fain, Romy; Barbosa, F. A. S.; Cárdenas, Jaime; Lipson, Michal

doi:10.1038/s41598-017-05746-7

Cited by 5 publications

(2 citation statements)

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“…The insertion force of the 100 μm flat probe to the brain cortex is about 0.5–0.6 mN 32 . The critical force for the buckling of the probe based on the Euler’s buckling equation is, F critical = Kπ 2 EI/L 2 , where K, E, I, and L are column effective length factor, modulus of elasticity, area moment of inertia, and length of the probe respectively 33 . Considering Fixed-Pinned or Fixed-Fixed boundary conditions (K = 2–4) 33 , modulus of elasticity of the polymer (E = 4 GPa), the probe length of 5 mm, and cross sectional area of 100 μm × 100 μm, critical force to buckle the probe is 25–50 mN.…”

Section: Resultsmentioning

confidence: 99%

Microphotonic needle for minimally invasive endoscopic imaging with sub-cellular resolution

Tadayon

Pavlova

Martyniuk

et al. 2018

Sci Rep

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Ultra-compact micro-optical elements for endoscopic instruments and miniaturized microscopes allow for non-invasive and non-destructive examination of microstructures and tissues. With sub-cellular level resolution such instruments could provide immediate diagnosis that is virtually consistent with a histologic diagnosis enabling for example to differentiate the boundaries between malignant and benign tissue. Such instruments are now being developed at a rapid rate; however, current manufacturing technologies limit the instruments to very large sizes, well beyond the sub-mm sizes required in order to ensure minimal tissue damage. We show here a platform based on planar microfabrication and soft lithography that overcomes the limitation of current optical elements enabling single cell resolution. We show the ability to resolve lithographic features that are as small as 2 μm using probes with a cross section that is only 100 microns in size. We also show the ability to image individual activated neural cells in brain slices via our fabricated probe.

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Section: Resultsmentioning

confidence: 99%

Microphotonic needle for minimally invasive endoscopic imaging with sub-cellular resolution

Tadayon

Pavlova

Martyniuk

et al. 2018

Sci Rep

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“…Multiphoton stimulation and microfabricated multi-site light delivery probes are among the most notable methods attempting to address invasiveness issues while achieving deep tissue light delivery. These methods aim to reduce tissue damage and immunological response while maintaining high precision and resolution, paving the way for non-destructive and minimally invasive optical stimulation and detection in deep tissue (Fain et al, 2017). Pisanello et al (2015) elaborated a technology tackling such challenges, through the use of tapered, nanostructured optical fibers as light delivery platforms for optical control of neural activity in vivo.…”

Section: Scopusmentioning

confidence: 99%

Neurophotonics: a comprehensive review, current challenges and future trends

Barros,

Cunha

2024

Front. Neurosci.

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The human brain, with its vast network of billions of neurons and trillions of synapses (connections) between diverse cell types, remains one of the greatest mysteries in science and medicine. Despite extensive research, an understanding of the underlying mechanisms that drive normal behaviors and response to disease states is still limited. Advancement in the Neuroscience field and development of therapeutics for related pathologies requires innovative technologies that can provide a dynamic and systematic understanding of the interactions between neurons and neural circuits. In this work, we provide an up-to-date overview of the evolution of neurophotonic approaches in the last 10 years through a multi-source, literature analysis. From an initial corpus of 243 papers retrieved from Scopus, PubMed and WoS databases, we have followed the PRISMA approach to select 56 papers in the area. Following a full-text evaluation of these 56 scientific articles, six main areas of applied research were identified and discussed: (1) Advanced optogenetics, (2) Multimodal neural interfaces, (3) Innovative therapeutics, (4) Imaging devices and probes, (5) Remote operations, and (6) Microfluidic platforms. For each area, the main technologies selected are discussed according to the photonic principles applied, the neuroscience application evaluated and the more indicative results of efficiency and scientific potential. This detailed analysis is followed by an outlook of the main challenges tackled over the last 10 years in the Neurophotonics field, as well as the main technological advances regarding specificity, light delivery, multimodality, imaging, materials and system designs. We conclude with a discussion of considerable challenges for future innovation and translation in Neurophotonics, from light delivery within the brain to physical constraints and data management strategies.

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