Photopatterning of thermally sensitive hydrogels useful for microactuators

Hoffmann, J.; Plötner, Matthias; Kuckling, Dirk; Fischer, Wolf‐Joachim

doi:10.1016/s0924-4247(99)00080-1

Cited by 153 publications

(127 citation statements)

References 3 publications

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“…However, the brittleness and inflexibility of pNIPAAM at high crosslink densities in the dehydrated state can pose handling problems 6 . Even more importantly, water volatility 30 means the lifetime of pNIPAAM-based hydrogels is dramatically reduced when used in open atmospheres 7 .…”

mentioning

confidence: 99%

Temperature and pH triggered release characteristics of water/fluorescein from 1-ethyl-3-methylimidazolium ethylsulfate based ionogels

et al. 2013

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confidence: 99%

Temperature and pH triggered release characteristics of water/fluorescein from 1-ethyl-3-methylimidazolium ethylsulfate based ionogels

et al. 2013

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“…Our strategy is based on ex situ photopatterning with simultaneous cross-linking, grafting and patterning of the hydrogel prior to closing the device. PNIPAM photopatterning is not new 34 , but it has never been used to make microfluidic devices. With this approach, we can raise the microfabrication technique to a level where the fabrication of a variety of devices becomes feasible under excellent resolution and control conditions.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic actuators based on temperature-responsive hydrogels

D'Eramo

Chollet

Leman³

et al. 2018

Microsyst Nanoeng

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The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive, but limitations, in terms of spatial resolution, speed, reliability and integration, have hindered its development during the past two decades. By patterning and grafting poly(N-isopropylacrylamide) PNIPAM hydrogel films on plane substrates with a 2 μm horizontal resolution and closing the system afterward, we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now. In this paper, we demonstrate, for the first time with this technology, devices with up to 7800 actuated micro-cages that sequester and release solutes, along with valves actuated individually with closing and opening switching times of 0.6 ± 0.1 and 0.25 ± 0.15 s, respectively. Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test (NAAT) for the Human Synaptojanin 1 gene, which is suspected to be involved in several neurodegenerative diseases such as Parkinson's disease. The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs, hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics, that are, pressure actuated polydimethylsiloxane (PDMS) valves and droplets.

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“…[1][2][3] Stimuli-responsive double hydrophilic polymers (DHPs) have applications as drug and gene nanocarriers, sensors, smart actuators, and catalysis. [4][5][6][7][8][9][10][11][12][13][14][15][16] Certain DHPs can supramolecularly self-assemble into more than one type of aggregates, i.e., so-called "schizophrenic" aggregation, in aqueous solution upon properly tuning external conditions.…”

Section: Introductionmentioning

confidence: 99%

Di-Stimuli Responsive Poly(<i>N</i>-Isopropylacrylamide-co-Diethylaminoethylmethacrylate) Copolymer: Synthesis, Characterization and Investigation of Aqueous Dispersion Properties

Islam

2014

ILCPA

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We report on the synthesis, characterization and aqueous dispersion properties of well-defined double hydrophilic copolymer with pH-and thermo-responsive segments via atom transfer radical polymerization (ATRP). Poly(N-isopropylacrylamide-co-Diethylaminoethylmeth-acrylate), P(NIPAAm-co-DEAEMA), was prepared by ATRP using methyl-4-bromomethyl benzoate initiator. The product was characterized by proton-nuclear magnetic resonance ( 1 H NMR) and attenuated total reflectance infrared (ATR-IR) spectroscopy. The multi-responsive switching between unimer and two types of micellar aggregates were characterized by temperature-dependent dynamic light scattering (DLS). Self-assembles into two types spherical aggregates in 1 mg/mL (0.0315 mM) aqueous solution, depending on solution pH and temperatures were widely investigated. The result shows two types of aggregate with large (280 nm) aggregate and variable sizes of small (17 nm, 25 nm, 45 nm) aggregates depending on temperature ranges from 26 to 40 °C at pH 4.

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Photopatterning of thermally sensitive hydrogels useful for microactuators

Cited by 153 publications

References 3 publications

Temperature and pH triggered release characteristics of water/fluorescein from 1-ethyl-3-methylimidazolium ethylsulfate based ionogels

Temperature and pH triggered release characteristics of water/fluorescein from 1-ethyl-3-methylimidazolium ethylsulfate based ionogels

Microfluidic actuators based on temperature-responsive hydrogels

Di-Stimuli Responsive Poly(<i>N</i>-Isopropylacrylamide-co-Diethylaminoethylmethacrylate) Copolymer: Synthesis, Characterization and Investigation of Aqueous Dispersion Properties

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