Photoperiodic modulation of voluntary ethanol intake in C57BL/6 mice

Rosenwasser, Alan M.; Fixaris, Michael C.; McCulley, Walter D.

doi:10.1016/j.physbeh.2015.05.011

Cited by 12 publications

(6 citation statements)

References 53 publications

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“…On experimental days, a skeleton photoperiod that allowed for continued entrainment was used, with lights on for 30 min at the beginning and end of the animal’s day. In skeleton photoperiods, animals continue their behavior as though it were a full photoperiod, with their inactive phase (subjective day) at the prior time of lights on, and their active phase (subjective night) at the prior time of lights off ( Patton et al, 2013 ; Rosenwasser et al, 2015 ). This lighting regimen provides the advantage of avoiding “masking”; i.e., the direct suppressive effects of light on activity that occurs in nocturnal species ( Pittendrigh and Minis, 1964 ; Pittendrigh, 1981 ; Mrosovsky and Hattar, 2003 ).…”

Section: Methodsmentioning

confidence: 99%

Brain Activity during Methamphetamine Anticipation in a Non-Invasive Self-Administration Paradigm in Mice

Juárez-Portilla

Pitter

Kim

et al. 2018

eNeuro

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Section: Methodsmentioning

confidence: 99%

Brain Activity during Methamphetamine Anticipation in a Non-Invasive Self-Administration Paradigm in Mice

Juárez-Portilla

Pitter

Kim

et al. 2018

eNeuro

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“…Multiple studies indicate that circadian disruption caused by irregular shift work or repeated jetlag increases the risk of developing AUD (Trinkoff and Storr, 1998 ; Hasler et al, 2014 ). Similarly, work in animal models has demonstrated that circadian disruption via exposure to constant light or continuously variable light-dark cycles can increase ethanol drinking, promote relapse, and contribute to the development of AUD and mood disorders such as anxiety and depression (Rosenwasser and Fixaris, 2013 ; Rosenwasser et al, 2015 ). Genetic models disrupting the molecular circadian clock have revealed similar results.…”

Section: Disruption Of Circadian Rhythms In Addictive Behaviorsmentioning

confidence: 99%

Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder

et al. 2018

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Alcohol use disorder (AUD) is a debilitating condition marked by cyclic patterns of craving, use, and withdrawal. These pathological behaviors are mediated by multiple neurotransmitter systems utilizing glutamate, GABA, dopamine, ATP, and adenosine. In particular, purines such as ATP and adenosine have been demonstrated to alter the phase and function of the circadian clock and are reciprocally regulated by the clock itself. Importantly, chronic ethanol intake has been demonstrated to disrupt the molecular circadian clock and is associated with altered circadian patterns of activity and sleep. Moreover, ethanol has been demonstrated to disrupt purinergic signaling, while dysfunction of the purinergic system has been implicated in conditions of drug abuse such as AUD. In this review, we summarize our current knowledge regarding circadian disruption by ethanol, focusing on the reciprocal relationship that exists between oscillatory neurotransmission and the molecular circadian clock. In particular, we offer detailed explanations and hypotheses regarding the concerted regulation of purinergic signaling and circadian oscillations by neurons and astrocytes, and review the diverse mechanisms by which purinergic dysfuction may contribute to circadian disruption or alcohol abuse. Finally, we describe the mechanisms by which ethanol may disrupt or hijack endogenous circadian rhythms to induce the maladaptive behavioral patterns associated with AUD.

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“…It has also been demonstrated that “binge” levels of EtOH administration can reverse sleep–wake cycles in rats (Sharma, Bradshaw, et al, 2014). Desynchronization of circadian rhythms and molecular clocks following chronic EtOH exposure has been reported previously in other studies in rodents; however, reviews of the topic have concluded that the effects are typically modest and that the results vary between species and strain (for reviews see Damaggio & Gorman, 2014b; Rosenwasser et al, 2015; Sarkar, 2012; Spanagel et al, 2005).…”

Section: Discussionmentioning

confidence: 66%

Use of a Fitbit‐like device in rats: Sex differences, relation to EEG sleep, and use to measure the long‐term effects of adolescent ethanol exposure

Ehlers

Wills

Benedict

et al. 2023

Alcohol: Clinical and Experimental Research

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Background: Sleep difficulties and rhythm disturbances are some of the problems associated with adolescent binge drinking. Recently, animal models of alcohol-induced insomnia have been developed. However, studies in human subjects have recently focused not only on nighttime EEG findings but also on daytime sleepiness and disrupted activity levels as typically measured by activity tracking devices such as the "Fitbit." We sought to develop and test a Fitbit-like device (the "FitBite") in rats and use it to track rest-activity cycles following adolescent alcohol exposure. Methods:The effects of 5 weeks of adolescent ethanol vapor or control conditions were evaluated in 48 male and female Wistar rats using FitBite activity while intoxicated, and during acute (24 h post-vapor exposure) and chronic withdrawal (4 weeks post-vapor exposure). Data were analyzed using activity count and cosinor analyses.Fourteen rats were subsequently implanted with cortical electrodes, and data from the FitBite were compared with EEG data to determine how well the FitBite could identify sleep and activity cycles.Results: Female rats were generally more active than males, with higher circadian rhythm amplitudes and mesors (rhythm-adjusted means) across a 24-h period. There were significant correlations between EEG-estimated sleep and activity counts using the FitBite. When the rats were tested during intoxication after 4 weeks of ethanol vapor exposure, they had significantly less overall activity. Disruptions in circadian rhythm were also found with significant decreases in the circadian amplitude, mesor, and a later shift in the acrophase. At 24 h of ethanol withdrawal, rats had more episodes of activity with shorter durations during the daytime, when rats are expected to spend more of their time sleeping. This effect remained at 4 weeks following withdrawal, but circadian rhythm disruptions were no longer present. Conclusions:A Fitbit-like device can be successfully used in rats to assess rest-activity cycles. Adolescent alcohol exposure produced circadian rhythm disturbances that were not observed after withdrawal. Fragmentation of ultradian rest-activity cycles

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Photoperiodic modulation of voluntary ethanol intake in C57BL/6 mice

Cited by 12 publications

References 53 publications

Brain Activity during Methamphetamine Anticipation in a Non-Invasive Self-Administration Paradigm in Mice

Brain Activity during Methamphetamine Anticipation in a Non-Invasive Self-Administration Paradigm in Mice

Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder

Use of a Fitbit‐like device in rats: Sex differences, relation to EEG sleep, and use to measure the long‐term effects of adolescent ethanol exposure

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