Photophysical and photochemical properties of potential porphyrin and chlorin photosensitizers for PDT

Zenkevich, É. I.; Sagun, E. I.; Knyukshto, V. N.; Шульга, А. М.; Mironov, A. F.; Efremova, Olga A.; Bonnett, Raymond; Songca, Sandile P.; Kassem, Mohammed A.

doi:10.1016/1011-1344(95)07241-1

Cited by 236 publications

(157 citation statements)

References 13 publications

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“…47 A decrease in the fluorescence yield in this case correlates with a decrease in the singlet oxygen generation efficiency and is due to the low solubility of the compounds and corresponding aggregation effects. 47 However, fluorescence of HPPH nanocrystals was found to recover in a time-dependent manner under in vitro conditions, in presence of 10% Fetal Bovine Serum (FBS). Typical cell culture media also contain similar concentration of either FBS or Horse Serum.…”

Section: Resultsmentioning

confidence: 99%

New Method for Delivering a Hydrophobic Drug for Photodynamic Therapy Using Pure Nanocrystal Form of the Drug

et al. 2007

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A carrier free method for delivery of a hydrophobic drug in its pure form, using nanocrystals (nano sized crystals) is proposed. To demonstrate this technique, nanocrystals of a hydrophobic photosensitizing anticancer drug 2-devinyl-2-(1-hexyloxyethyl)pyropheophorbide (HPPH), have been synthesized using re-precipitation method. The resulting drug nanocrystals were monodispersed and stable in aqueous dispersion, without the necessity of an additional stabilizer (surfactant). As shown by confocal microscopy, these pure drug nanocrystals were taken-up by the cancer cells with high avidity. Though the fluorescence and photodynamic activity of the drug were substantially quenched in the form of nanocrystals in aqueous suspension, both these characteristics were recovered under in vitro and in vivo conditions. This recovery of drug activity and fluorescence is possibly due to the interaction of nanocrystals with serum albumin, resulting in conversion of the drug nanocrystals into the molecular form. This was confirmed by demonstrating similar recovery in presence of Fetal Bovine Serum (FBS) or Bovine Serum Albumin (BSA). Under similar treatment conditions, the HPPH in nanocrystal form or in 1% Tween 80/water formulation showed comparable in vitro and in vivo efficacy.

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Section: Resultsmentioning

confidence: 99%

New Method for Delivering a Hydrophobic Drug for Photodynamic Therapy Using Pure Nanocrystal Form of the Drug

et al. 2007

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“…The Stocks's shift (Δν I St ) calculated for 1 from absorption and emission spectral data does not exceed the value for chlorin e 6 in ethanol (5-6 nm) given. [20] This quantity is similar for aromatic tetrapyrroles with a relatively planar structure. [21] Shifts for the starting macrocycle 3 are 1-3 nm higher.…”

Section: Synthesis and Spectral Identificationmentioning

confidence: 99%

The Synthesis and Singlet Oxygen Generation Study of 13(1)-N-Piperazinyl Chlorin e6-15(2),17(3)-Dimethyl Ester

Berezin¹,

Karimov²,

Venediktov³

et al. 2015

MHC

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“…Meso-tetraphenylporphyrin (TPP) in toluene was used as reference (Φ ∆ = 0.68). 26 The chlorin samples in toluene and the reference were excited at 420 nm (OD 420 nm = 0.1). As can be seen from Table 2, all the synthesized chlorins are able to generate singlet oxygen.…”

Section: Resultsmentioning

confidence: 99%

1,3-Dipolar cycloaddition of nitrile imines to meso-tetraarylporphyrins

Moura¹,

Giuntini²,

Faustino³

et al. 2009

Arkivoc

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N-Aryl-C-ethoxycarbonylnitrile imines react with meso-tetrakis(pentafluorophenyl)porphyrin in 1,3-dipolar cycloadditions to yield novel pyrazolochlorins in moderate yields. The nitrile imines were generated in situ by base-induced dehydrobromination of ethyl hydrazono-α-bromoglyoxylates. A number of different experimental conditions were considered for these cycloadditions, namely different bases, solvents and temperature; the best results were obtained using potassium carbonate in refluxing toluene. The photophysical properties of the new chlorins were investigated and the results suggest that two of them have potential for use in photodynamic therapy.

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Photophysical and photochemical properties of potential porphyrin and chlorin photosensitizers for PDT

Cited by 236 publications

References 13 publications

New Method for Delivering a Hydrophobic Drug for Photodynamic Therapy Using Pure Nanocrystal Form of the Drug

New Method for Delivering a Hydrophobic Drug for Photodynamic Therapy Using Pure Nanocrystal Form of the Drug

The Synthesis and Singlet Oxygen Generation Study of 13(1)-N-Piperazinyl Chlorin e6-15(2),17(3)-Dimethyl Ester

1,3-Dipolar cycloaddition of nitrile imines to meso-tetraarylporphyrins

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