Photophysical properties and photodynamic therapy activities of detonated nanodiamonds-BODIPY-phthalocyanines nanoassemblies

Matshitse, Refilwe; Ngoy, Bokolombe P.; Managa, Muthumuni; Mack, John; Nyokong, Tebello

doi:10.1016/j.pdpdt.2019.03.007

Cited by 28 publications

(20 citation statements)

References 49 publications

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“…The coupling of oxasmaragdyrins with BODIPY enhances the photosensitization of 89 (Scheme 46). A nanocomposite consisting of Pc, BODIPY, and DNDs with the aim of improving PDT activity through synergistic effect was synthesized [66]. The composites were constructed under the covalent linking of the DNDs carboxylic groups and the hydroxyl moiety of the BODIPY, (ZnTPPcQ) was then adsorbed onto DNDs-BODIPY via π-π stacking interaction (Scheme 48).…”

Section: Axially Coordinated Bodipy-pc Conjugatesmentioning

confidence: 99%

BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment

et al. 2022

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Fluorescent dyes absorbing and emitting in the visible and near-IR regions are promising for the development of fluorescent probes for labeling and bio-visualization of body cells. The ability to absorb and emit in the long-wavelength region increases the efficiency of recording the spectral signals of the probes due to the higher permeability of the skin layers. Compared to other fluorescent dyes, BODIPYs are attractive due to their excellent photophysical properties–narrow absorption and emission, intense fluorescence, simple signal modulation for the practical applications. As part of conjugates with biomolecules, BODIPY could act as a biomarker, but as therapeutic agent, which allows solving several problems at once-labeling or bioimaging and treatment based on the suppression of pathogenic microflora and cancer cells, which provides a huge potential for practical application of BODIPY conjugates in medicine. The review is devoted to the discussion of the recent, promising directions of BODIPY application in the field of conjugation with biomolecules. The first direction is associated with the development of BODIPY conjugates with drugs, including compounds of platinum, paclitaxel, chlorambucil, isoxazole, capsaicin, etc. The second direction is devoted to the labeling of vitamins, hormones, lipids, and other biomolecules to control the processes of their transport, localization in target cells, and metabolism. Within the framework of the third direction, the problem of obtaining functional optically active materials by conjugating BODIPY with other colored and fluorescent particles, in particular, phthalocyanines, is being solved.

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Section: Axially Coordinated Bodipy-pc Conjugatesmentioning

confidence: 99%

BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment

et al. 2022

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“…Refilwe et al. ( 36 ) developed ZnTPPcQ-DNDs-BODIPY (conjugated with ZnPc, nanodiamond, and halogenated BODIPY) as PSs with higher 1 O 2 quantum yield in water solution by testing fluorescence lifetimes from time-correlated single photon counting methods, thus, the three-component nanoassembly worked better than the free individual components.…”

Section: Nanotechnologymentioning

confidence: 99%

Advances in Photodynamic Therapy Based on Nanotechnology and Its Application in Skin Cancer

et al. 2022

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Comprehensive cancer treatments have been widely studied. Traditional treatment methods (e.g., radiotherapy, chemotherapy), despite ablating tumors, inevitably damage normal cells and cause serious complications. Photodynamic therapy (PDT), with its low rate of trauma, accurate targeting, synergism, repeatability, has displayed great advantages in the treatment of tumors. In recent years, nanotech-based PDT has provided a new modality for cancer treatment. Direct modification of PSs by nanotechnology or the delivery of PSs by nanocarriers can improve their targeting, specificity, and PDT efficacy for tumors. In this review, we strive to provide the reader with a comprehensive overview, on various aspects of the types, characteristics, and research progress of photosensitizers and nanomaterials used in PDT. And the application progress and relative limitations of nanotech-PDT in non-melanoma skin cancer and melanoma are also summarized.

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“…196 3 Effect on photophysical properties due to GQD-Pp/Pc hybrid nanocomposites Broad knowledge on the complex multicomponent architectures of GQD-Pp/Pc hybrids remains unclear in terms of photophysical behavior including electron transfer dynamics. 5,130,142,167,168,197 Porphyrins can easily govern their conformation to comply with their local environment via reorientations of their axial/peripheral ligands and macrocycle deformations, which are usually induced by molecule-substrate interactions. 163,169,198 The center-oxidized configurations of GQDs cause a larger perturbation in their conjugated π-system, reducing their band gap, and causing a redshift in their absorption spectrum.…”

Section: Characterization Of Gqd-based Porphyrin Hybrid Systemsmentioning

confidence: 99%